Ritanserin potentiates the stimulatory effects of raclopride on neuronal activity and dopamine release selectively in the mesolimbic dopaminergic system

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors

1985 • 1,855 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task

1993 • 1,279 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors

1985 • 803 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Specific in vitro and in vivo binding of 3H-raclopride a potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain

1985 • 503 citations

Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist.

1985 • 444 citations

Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

1988 • 429 citations

Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study

1990 • 407 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

Schizophrenia: A Subcortical Neurotransmitter Imbalance Syndrome?

1990 • 335 citations

Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area

1992 • 315 citations

Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons

1984 • 312 citations

The Risks and Benefits of Clozapine versus Chlorpromazine

1987 • 299 citations

THE VARIABILITY OF CENTRAL NEURAL ACTIVITY IN A SENSORY SYSTEM, AND ITS IMPLICATIONS FOR THE CENTRAL REFLECTION OF SENSORY EVENTS

1963 • 297 citations

Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system

1973 • 296 citations

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

1989 • 266 citations

Effects of antipsychotic drugs on serotonin receptors.

1991 • 260 citations

Mechanisms of action of atypical antipsychotic drugs

1991 • 254 citations

Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization

1981 • 242 citations

Regulation of the mesocorticolimbic dopamine system by glutamic acid receptor subtypes.

1989 • 216 citations

Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.

1992 • 192 citations

Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain

1986 • 177 citations

Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system

1976 • 176 citations

Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites

1990 • 173 citations

5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine

1992 • 160 citations

Local cooling of pre‐frontal cortex induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1989 • 151 citations

Behavioral aspects of serotonin-dopamine interaction in the monkey

1985 • 146 citations

5‐Hydroxytryptamine acts at 5‐HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones.

1989 • 139 citations

Acute effects of bupropion on extracellular dopamine concentrations in rat striatum and nucleus accumbens studied by in vivo microdialysis

1989 • 134 citations

Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones

1983 • 134 citations

Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex

1994 • 126 citations

Neuronal activity in the ventral tegmental area (VTA) during motivated bar press feeding in the monkey

1987 • 121 citations

Intrastriatal injection of dl-2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy that is antagonized by haloperidol and clozapine

1986 • 118 citations

Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones

1982 • 111 citations

Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization

1993 • 111 citations

Differential effects of acute clozapine and haloperidol on the activity of ventral tegmental (A10) and nigrostriatal (A9) dopamine neurons

1987 • 110 citations

Thymosthenic Agents, A Novel Approach in the Treatment of Schizophrenia

1989 • 109 citations

Effects of chronic bupropion on interstitial concentrations of dopamine in rat nucleus accumbens and striatum.

1992 • 109 citations

The efficacy of the D2 and 5-HT2 antagonist risperidone (R 64 766) in the treatment of chronic psychosis

1989 • 96 citations

5-HT2 receptor blockade by ICI 169,369 and other 5-HT2 antagonists modulates the effects of D-2 dopamine receptor blockade.

1990 • 88 citations

Effects of Frequency and Pattern of Medial Forebrain Bundle Stimulation on Caudate Dialysate Dopamine and Serotonin

1992 • 86 citations

Firing patterns of midbrain dopamine neurons: differences between A9 and A10 cells

1988 • 84 citations

Clozapine—A serotonin antagonist?

1984 • 81 citations

The excitatory amino acid antagonist kynurenate induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1998 • 78 citations

Receptor binding properties of amperozide

1990 • 68 citations

Gaps and peculiarities in 5-HT2 receptor studies.

1990 • 62 citations

Inhibition of spontaneous and evoked unit activity in the rat medial prefrontal corte by mesencephalic raphe nuclei

1990 • 61 citations

Effects of amperozide in schizophrenia

1991 • 59 citations

Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy induced by SCH 23390 in the rat

1992 • 59 citations

Effects of amperozide, a putative antipsychotic drug, on rat midbrain dopamine neurons recorded in vivo

1990 • 53 citations

Alterations in Extracellular and Tissue Levels of Biogenic Amines in Rat Brain Induced by the Serotonin₂ Receptor Antagonist, Ritanserin

1992 • 51 citations

Receptor occupancy by ritanserin and risperidone measured using ex vivo autaradiography

1989 • 46 citations

Prazosin modulates the changes in firing pattern and transmitter release induced by raclopride in the mesolimbic, but not in the nigrostriatal dopaminergic system

1994 • 43 citations

Effects of antipsychotic drugs on 5-HT2 receptors in the medial prefrontal cortex: microiontophoretic studies

1990 • 43 citations

Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction

1989 • 37 citations

The 5‐HT₂ antagonist ritanserin blocks the effect of pre‐frontal cortex inactivation on rat A10 dopamine neurons in vivo

1989 • 29 citations

New selective dopamine D-2 antagonists as antipsychotic agents. Pharmacological, chemical, structural and theoretical considerations.

1987 • 25 citations

Effects of amperozide on psychostimulant-induced hyperlocomotion and dopamine release in the nucleus accumbens

1993 • 24 citations

Autoradiography of 5-HT receptors: A critical appraisal

1991 • 20 citations

Low dose raclopride spares the extrapyramidal system in rat brain from metabolic effects

1993 • 19 citations

Neurochemical effects of chronic co-administration of ritanserin and haloperidol: comparison with clozapine effects

1990 • 18 citations

The limbic functional selectivity of amperozide is not mediated by dopamine D2 receptors as assessed by in vitro and in vivo binding

1994 • 13 citations