Cognitive and neuronal systems underlying obesity

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Prevalence and Trends in Obesity Among US Adults, 1999-2008

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A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement

1972 • 6,687 citations

Classical conditioning II: Current research and theory.

1972 • 4,453 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

2010 • 3,007 citations

A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.

1980 • 2,919 citations

The Physiology of Glucagon-like Peptide 1

2007 • 2,882 citations

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

2001 • 2,865 citations

A theory of attention: Variations in the associability of stimuli with reinforcement.

1975 • 2,731 citations

The debate over dopamine’s role in reward: the case for incentive salience

2006 • 2,256 citations

Food reward: Brain substrates of wanting and liking

1996 • 1,831 citations

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

1997 • 1,137 citations

An economic analysis of adult obesity: results from the Behavioral Risk Factor Surveillance System

2004 • 1,114 citations

Expression of ghrelin receptor mRNA in the rat and the mouse brain

2005 • 1,029 citations

Motivational control of goal-directed action

1994 • 980 citations

Conditioned Aversion to Saccharin Resulting from Exposure to Gamma Radiation

1955 • 961 citations

A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

2002 • 853 citations

A pathophysiological framework of hippocampal dysfunction in ageing and disease

2011 • 824 citations

The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data

1994 • 807 citations

Ghrelin controls hippocampal spine synapse density and memory performance

2006 • 806 citations

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

2003 • 788 citations

Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system

1999 • 733 citations

Obesity prevalence from a European perspective: a systematic review

2008 • 731 citations

Finite Scale of Spatial Representation in the Hippocampus

2008 • 701 citations

Reward Mechanisms in Obesity: New Insights and Future Directions

2011 • 695 citations

Handbook of children and the media

2001 • 673 citations

Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis

1988 • 619 citations

The Brain, Appetite, and Obesity

2007 • 614 citations

Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity

2010 • 609 citations

The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats

1978 • 582 citations

A motivational view of learning, performance, and behavior modification.

1974 • 559 citations

Obesity and Eating

1968 • 545 citations

A direct projection from Ammon's horn to prefrontal cortex in the rat

1981 • 528 citations

Projections of the ventral subiculum to the amygdala, septum, and hypothalamus: A PHAL anterograde tract‐tracing study in the rat

1992 • 524 citations

Opioid modulation of taste hedonics within the ventral striatum

2002 • 514 citations

Dietary Fats and the Risk of Incident Alzheimer Disease

2003 • 505 citations

Précis of O'Keefe & Nadel'sThe hippocampus as a cognitive map

1979 • 487 citations

Leptin targets in the mouse brain

2009 • 448 citations

Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity

2001 • 396 citations

Obesity and socioeconomic status in adults: United States, 2005-2008.

2010 • 385 citations

Hippocampus and context in classical conditioning

1999 • 379 citations

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

2008 • 369 citations

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

2010 • 360 citations

Hunger, obesity, and the ventromedial hypothalamus.

1972 • 344 citations

Intracerebroventricular insulin enhances memory in a passive-avoidance task

2000 • 341 citations

Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens.

1998 • 322 citations

On the directional firing properties of hippocampal place cells

1994 • 322 citations

Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding

2007 • 310 citations

Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study

2008 • 307 citations

Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease

2004 • 304 citations

Effects of leptin on memory processing

2005 • 297 citations

Dietary fat intake and 6-year cognitive change in an older biracial community population

2004 • 296 citations

Homeostatic and Non‐homeostatic Pathways Involved in the Control of Food Intake and Energy Balance

2006 • 291 citations

Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons

2010 • 288 citations

Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study

1994 • 281 citations

Energy Density, Portion Size, and Eating Occasions: Contributions to Increased Energy Intake in the United States, 1977–2006

2011 • 276 citations

The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat

2010 • 274 citations

What Causes Humans to Begin and End a Meal? A Role for Memory for What Has Been Eaten, as Evidenced by a Study of Multiple Meal Eating in Amnesic Patients

1998 • 258 citations

Anterograde and retrograde tracing of projections from the ventral tegmental area to the hippocampal formation in the rat

1994 • 256 citations

Leptin receptor action and mechanisms of leptin resistance

2005 • 255 citations

Insulin dose–response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: interactions with apolipoprotein E genotype

2003 • 253 citations

Context, Ambiguity, and Classical Conditioning

1994 • 251 citations

Manipulated time and eating behavior.

1968 • 224 citations

The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat

2007 • 220 citations

Differential Effects of Dorsal and Ventral Hippocampal Lesions

1998 • 216 citations

Effect of Satiation on Brain Activity in Obese and Lean Women

2001 • 210 citations

Mesocorticolimbic Dopamine Systems and Reward

1988 • 207 citations

A role for hippocampus in the utilization of hunger signals

1993 • 206 citations

Dorsal/ventral hippocampus, fornix, and conditioned place preference

2001 • 198 citations

Genetic approaches to understanding human obesity

2011 • 196 citations

Insulin, leptin, and food reward: update 2008

2008 • 195 citations

Amygdalar and Prefrontal Pathways to the Lateral Hypothalamus Are Activated by a Learned Cue That Stimulates Eating

2005 • 193 citations

Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone

2011 • 192 citations

Amygdalo-Hypothalamic Circuit Allows Learned Cues to Override Satiety and Promote Eating

2002 • 192 citations

Persistence of abnormal neural responses to a meal in postobese individuals

2003 • 190 citations

A biochemical and functional characterization of diet‐induced brain insulin resistance

2005 • 188 citations

External cues in the control of food intake in humans: The sensory-normative distinction

2008 • 188 citations

Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation

2008 • 188 citations

Neural control of appetite: cross-talk between homeostatic and non-homeostatic systems

2004 • 185 citations

Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens

2002 • 183 citations

Diminished ability to interpret and report internal states after bilateral medial temporal resection: Case H.M.

1985 • 180 citations

Electrophysiology of the Hippocampal and Amygdaloid Projections to the Nucleus Accumbens of the Rat: Convergence, Segregation, and Interaction of Inputs

1998 • 176 citations

Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

2011 • 176 citations

Memory inhibition and energy regulation

2005 • 176 citations

Instrumental performance following a shift in primary motivation depends on incentive learning.

1992 • 175 citations

Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet.

2010 • 174 citations

Sham feeding corn oil increases accumbens dopamine in the rat

2006 • 171 citations

Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice

2009 • 170 citations

Diminished ability to interpret and report internal states after bilateral medial temporal resection: Case H.M.

1985 • 169 citations

A potential role for the hippocampus in energy intake and body weight regulation

2007 • 168 citations

Memory for recent eating and its influence on subsequent food intake

2002 • 168 citations

Children and Television Advertising

1996 • 166 citations

Chapter 22 A computational theory of the hippocampal cognitive map

1990 • 166 citations

Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry

2006 • 161 citations

Localization of leptin receptor mRNA expression in mouse brain

1996 • 159 citations

Sensory experience of food and obesity: a positron emission tomography study of the brain regions affected by tasting a liquid meal after a prolonged fast

2004 • 156 citations

Diet-induced obesity and spatial cognition in young male rats

2008 • 153 citations

Insulin resistance and pathological brain ageing

2011 • 153 citations

Analysis of direct hippocampal cortical field CA1 axonal projections to diencephalon in the rat

2006 • 148 citations

Cognitive influences on food intake: The effects of manipulating memory for recent eating

2008 • 147 citations

Hippocampal Leptin Signaling Reduces Food Intake and Modulates Food-Related Memory Processing

2011 • 144 citations

Post-ingestive positive controls of ingestive behavior

2001 • 142 citations

Retrieving Memories via Internal Context Requires the Hippocampus

2004 • 139 citations

Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake.

1996 • 138 citations

A high fructose diet impairs spatial memory in male rats

2009 • 138 citations

Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity

2010 • 134 citations

Context, conditioning, and hippocampal rerepresentation in animal learning.

1994 • 132 citations

Robust conditioned flavor preference produced by intragastric starch infusions in rats

1988 • 131 citations

Multiple brain sites sensitive to feeding stimulation by opioid agonists: A cannula-mapping study

1988 • 131 citations

Reinforcement value of sucrose measured by progressive ratio operant licking in the rat

2003 • 126 citations

Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake.

1996 • 125 citations

A neural systems analysis of the potentiation of feeding by conditioned stimuli

2005 • 123 citations

Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss

2004 • 122 citations

Meal initiation controlled by learned cues: Basic behavioral properties

1984 • 122 citations

Sensory-Specific Satiety Is Intact in Amnesics Who Eat Multiple Meals

2008 • 121 citations

The satiety effect of cholecystokinin: A progress report

1981 • 119 citations

Intragastric glucose but not fructose conditions robust flavor preferences in rats

1993 • 119 citations

The effects of amygdala lesions on conditioned stimulus-potentiated eating in rats

2002 • 118 citations

Possible entrainment of ghrelin to habitual meal patterns in humans

2008 • 113 citations

The cognitive map as a hippocampus

1979 • 111 citations

Context, conditioning, and hippocampal rerepresentation in animal learning.

1994 • 111 citations

The effects of morphine on diet selection are dependent upon baseline diet preferences

1990 • 108 citations

Medial Prefrontal Cortex Is Necessary for an Appetitive Contextual Conditioned Stimulus to Promote Eating in Sated Rats

2007 • 108 citations

Effect of context on performance to conditioned stimuli with mixed histories of reinforcement and nonreinforcement.

1986 • 108 citations

Ghrelin and food reward: The story of potential underlying substrates

2011 • 107 citations

Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice

2010 • 107 citations

Characterization and Regulation of Insulin Receptors in Rat Brain

1984 • 101 citations

Naltrexone administered to central nucleus of amygdala or PVN: neural dissociation of diet and energy

2000 • 100 citations

Reconsideration of the role of the hippocampus in learned inhibition

2001 • 98 citations

Little and often: Ingestive behavior patterns following hippocampal lesions in rats.

1998 • 97 citations

Learned contextual cue potentiates eating in rats

2006 • 97 citations

Longitudinal study of the effects of a high-fat diet on glucose regulation, hippocampal function, and cerebral insulin sensitivity in C57BL/6 mice

2006 • 96 citations

The hippocampus and inhibitory learning: a ‘Gray’ area?

2004 • 96 citations

Hippocampal lesions impair retention of discriminative responding based on energy state cues.

2010 • 96 citations

Carbohydrate taste preferences in rats: Glucose, sucrose, maltose, fructose and polycose compared

1987 • 95 citations

Potency of naloxone's anorectic effect in rats is dependent on diet preference

1996 • 94 citations

Diet‐induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress

2011 • 92 citations

Paraventricular opioids alter intake of high-fat but not high-sucrose diet depending on diet preference in a binge model of feeding

2007 • 91 citations

Advertising in the United States

1900 • 91 citations

Little and often: Ingestive behavior patterns following hippocampal lesions in rats.

1998 • 88 citations

“Is this a meal or snack?” Situational cues that drive perceptions

2009 • 87 citations

The effects of high fat diets on the blood–brain barrier transport of leptin: Failure or adaptation?

2006 • 79 citations

Effect of naloxone and naltrexone on the development of satiation measured in the runway: Comparisons with d-amphetamine and d-fenfluramine

1986 • 79 citations

Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat

1998 • 76 citations

Learning about deprivation intensity stimuli.

1987 • 72 citations

The hippocampus and reward: Effects of hippocampal lesions on progressive-ratio responding.

1996 • 72 citations

The hippocampus and reward: Effects of hippocampal lesions on progressive-ratio responding.

1996 • 70 citations

Metabolic Syndrome, Cognitive Performance, and Dementia

2012 • 69 citations

Learned and cognitive controls of food intake

2010 • 69 citations

Nucleus accumbens opioids regulate flavor-based preferences in food consumption

2006 • 65 citations

Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: Involvement of opioids, orexin, oxytocin and NPY

2008 • 65 citations

Learning about deprivation intensity stimuli.

1987 • 62 citations

Conditioned Sucrose Aversions Produced by Naloxone-Precipitated Withdrawal From Acutely Administered Morphine

1997 • 60 citations

Functional differentiation within the medial temporal lobe in the rat

2004 • 58 citations

Differential leptin access into the brain — A hierarchical organization of hypothalamic leptin target sites?

2008 • 57 citations

The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation

2005 • 52 citations

Gastric distention induced functional magnetic resonance signal changes in the rodent brain

2011 • 49 citations

Effects of naloxone and naltrexone on meal patterns of freely-feeding rats

1987 • 43 citations

Opioids as facilitators of feeding: Can any food be rewarding?

2011 • 41 citations

Evidence for motivational effects elicited by activation of GABA-A or dopamine receptors in the nucleus accumbens shell

2010 • 38 citations

Nucleus accumbens opioid signaling conditions short-term flavor preferences

2007 • 35 citations

Pavlovian conditioning and extinction of context cues and punctate CSs in rats with ibotenate lesions of the hippocampus

1999 • 33 citations

Novel actions of leptin in the hippocampus

2003 • 33 citations

When snacks become meals: How hunger and environmental cues bias food intake

2010 • 30 citations

Opposing effects of intra-nucleus accumbens mu and kappa opioid agonists on sensory specific satiety

2007 • 30 citations

Interoceptive “satiety” signals produced by leptin and CCK

2007 • 24 citations

Synaptology of ventral CA1 and subiculum projections to the basomedial nucleus of the amygdala in the mouse: relation to GABAergic interneurons

2011 • 19 citations

Transfer between contextual conditional discriminations: An examination of how stimulus conjunctions are represented.

2001 • 19 citations

Scheduled feeding results in adipogenesis and increased acylated ghrelin

2011 • 18 citations

Conditioned taste aversion from neostigmine or methyl-naloxonium in the nucleus accumbens

2011 • 18 citations

Discriminative cues produced by NPY do not generalize to the interoceptive cues produced by food deprivation

1995 • 17 citations

The learned function of food-deprivation cues: A role for conditioned modulation

1996 • 15 citations

Feeding association between the nucleus of the solitary tract and the ventral tegmental area

2009 • 12 citations

Motivation and Emotion

2001 • 3 citations