A high fructose diet impairs spatial memory in male rats

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity

2004 • 1,951 citations

Fructose, weight gain, and the insulin resistance syndrome,,

2002 • 1,034 citations

Fructose-induced insulin resistance and hypertension in rats.

1987 • 885 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Fructose, insulin resistance, and metabolic dyslipidemia

2005 • 824 citations

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

1998 • 753 citations

Intermediary metabolism of fructose

1993 • 654 citations

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

2008 • 552 citations

Type 2 diabetes mellitus, cognitive impairment and dementia

1999 • 550 citations

Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies

1997 • 534 citations

Dietary Fructose: Implications for Dysregulation of Energy Homeostasis and Lipid/Carbohydrate Metabolism

2005 • 527 citations

Brain Insulin Receptors and Spatial Memory

1999 • 516 citations

Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier

2004 • 492 citations

Dietary Fructose: Implications for Dysregulation of Energy Homeostasis and Lipid/Carbohydrate Metabolism

2005 • 491 citations

Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey.

2008 • 426 citations

Manufacturing, composition, and applications of fructose

1993 • 421 citations

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight

1999 • 398 citations

Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity

2001 • 396 citations

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

2008 • 369 citations

National trends in soft drink consumption among children and adolescents age 6 to 17 years: Prevalence, amounts, and sources, 1977/1978 to 1994/1998

2003 • 353 citations

Food Consumption, Prices, and Expenditures, 1970-97

1999 • 308 citations

Effects of leptin on memory processing

2005 • 297 citations

Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding

2008 • 289 citations

Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition☆

2007 • 289 citations

A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans

2006 • 287 citations

The Hippocampus and Memory for “What,” “Where,” and “When”

2004 • 280 citations

Cognitive effects of insulin in the central nervous system

2001 • 269 citations

Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats

2006 • 266 citations

Consumption of Sweetened Beverages and Intakes of Fructose and Glucose Predict Type 2 Diabetes Occurrence

2007 • 260 citations

Effect of fructose feeding on insulin secretion and insulin action in the rat

1980 • 256 citations

Hepatic Very Low Density Lipoprotein-ApoB Overproduction Is Associated with Attenuated Hepatic Insulin Signaling and Overexpression of Protein-tyrosine Phosphatase 1B in a Fructose-fed Hamster Model of Insulin Resistance

2002 • 237 citations

Intakes and food sources of fructose in the United States

1993 • 229 citations

High Dietary Fructose Induces a Hepatic Stress Response Resulting in Cholesterol and Lipid Dysregulation

2003 • 223 citations

Immunohistochemical localization of leptin receptor in the rat brain

1998 • 218 citations

Fructose-Induced Fatty Liver Disease

2005 • 213 citations

Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging

2005 • 206 citations

Hippocampus and remote spatial memory in rats

2004 • 206 citations

Insulin receptor signaling in long-term memory consolidation following spatial learning

2005 • 205 citations

Links between cognitive impairment in insulin resistance: An explanatory model

2005 • 197 citations

Mechanism of insulin resistance in fructose-fed rats

1982 • 189 citations

Learning and memory impairment in rats fed a high saturated fat diet

1990 • 189 citations

A biochemical and functional characterization of diet‐induced brain insulin resistance

2005 • 188 citations

Retrograde amnesia after hippocampal damage: Recent vs. remote memories in two tasks

2001 • 186 citations

Retrograde amnesia: neither partial nor complete hippocampal lesions in rats result in preferential sparing of remote spatial memory, even after reminding

2004 • 152 citations

Substituting Honey for Refined Carbohydrates Protects Rats from Hypertriglyceridemic and Prooxidative Effects of Fructose

2002 • 151 citations

Effect of Glucose and Fructose Administration on Lipid Metabolism in the Rat

1968 • 150 citations

Retrograde amnesia and selective damage to the hippocampal formation: memory for places and object discriminations

1999 • 148 citations

Retrograde amnesia and memory reactivation in rats with ibotenate lesions to the hippocampus or subiculum.

1994 • 146 citations

Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols

2008 • 143 citations

Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake.

1996 • 138 citations

Fructose: metabolism and short-term effects on carbohydrate and purine metabolic pathways.

1986 • 134 citations

Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake.

1996 • 125 citations

Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase

1992 • 113 citations

Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats.

2005 • 96 citations

Longitudinal study of the effects of a high-fat diet on glucose regulation, hippocampal function, and cerebral insulin sensitivity in C57BL/6 mice

2006 • 96 citations

The effect of intrahippocampal insulin microinjection on spatial learning and memory

2006 • 90 citations

Defining and interpreting intakes of sugars

2003 • 88 citations

The effects of a high-fat, high-fructose, and combination diet on learning, weight, and glucose regulation in C57BL/6 mice

2006 • 81 citations

Hippocampal synaptic enhancement and spatial learning in the morris swim task

1993 • 70 citations

The Concentrations of Fructose, Glucose and Lactate in the Splanchnic Blood Vessels of Rats Absorbing Fructose

1971 • 70 citations

Expression of fructose sensitive glucose transporter in the brains of fructose-fed rats

2006 • 63 citations

Intra CA1 insulin microinjection improves memory consolidation and retrieval

2007 • 56 citations

Effects of fructose and glucose on plasma leptin, insulin, and insulin resistance in lean and VMH-lesioned obese rats

2000 • 53 citations

Fructose metabolism in the cerebellum

2007 • 51 citations

A Dietary Fat Excess Alters Metabolic and Neuroendocrine Responses Before the Onset of Metabolic Diseases

2008 • 51 citations

Dietary Assessment of Major Trends in U.S. Food Consumption, 1970-2005

2012 • 51 citations

Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

2008 • 49 citations

Effects of triglyceride on ER stress and insulin resistance

2007 • 49 citations

Effect of a Proanthocyanidin-Rich Extract from Longan Flower on Markers of Metabolic Syndrome in Fructose-Fed Rats

2008 • 42 citations

Central Nervous Effects of Leptin and Insulin on Hippocampal Leptin and Insulin Receptor Expression following a Learning Task in Wistar Rats

2005 • 29 citations

DISTRIBUTION OF INTRAVENOUSLY INJECTED FRUCTOSE AND GLUCOSE BETWEEN BLOOD AND BRAIN

1946 • 29 citations

PERMEABILITY OF THE BLOOD‐BRAIN BARRIER TO FRUCTOSE AND THE ANAEROBIC USE OF FRUCTOSE IN THE BRAINS OF YOUNG MICE¹

1972 • 24 citations

Fat distribution and changes in the blood brain barrier in a rat model of cerebral arterial fat embolism

1998 • 24 citations

Involvement of nitric oxide in insulin induced memory improvement

2008 • 23 citations

Impact of a Long-Term Sildenafil Treatment on Pressor Response in Conscious Rats With Insulin Resistance and Hypertriglyceridemia

2008 • 19 citations

Determination of Ascorbic Acid in Presence of Interfering Substances by the ‘ Continuous-Flow’ Method

1947 • 17 citations

Dietary recommendations, goals and guidelines.

1994 • 4 citations

Imaging strategy for South African children with their first proven UTI in a tertiary hospital setting

2001 • 1 citations