Apoptosis: unmasking the executioner

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Caspases: killer proteases

1997 • 2,440 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

The role of proteases during apoptosis

1996 • 558 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum

1997 • 322 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis.

1997 • 259 citations

The Bcl-2 family of proteins: regulators of cell death and survival

1994 • 238 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells

1996 • 120 citations

Accumulation of soluble fas in inflamed joints of patients with rheumatoid arthritis

1997 • 104 citations

Portrait of an executioner: the molecular mechanism of Fas/APO-1-induced apoptosis

1997 • 100 citations

Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

1997 • 72 citations

Release of mitochondrial matrix proteins through a Ca2+-requiring, cyclosporin-sensitive pathway

1989 • 71 citations

The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system

1997 • 61 citations

Ca2+-induced, phospholipase-independent injury during reoxygenation of anoxic mitochondria

1993 • 31 citations