Cell–cell contact between marrow stromal cells and myeloma cells via VCAM-1 and α4β1-integrin enhances production of osteoclast-stimulating activity

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Osteoclast-Like Cell Formation and its Regulation by Osteotropic Hormones in Mouse Bone Marrow Cultures*

1988 • 745 citations

Evidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma

1974 • 681 citations

Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients

1997 • 491 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture.

1991 • 399 citations

Multiple Myeloma

1997 • 389 citations

Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells

1987 • 386 citations

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells.

1991 • 234 citations

Expression of the integrin $alpha;4$beta;1 on melanoma cells can inhibit the invasive stage of metastasis formation

1994 • 221 citations

Elevated Serum Concentrations of Hepatocyte Growth Factor in Patients With Multiple Myeloma

1998 • 214 citations

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1991 • 194 citations

Animal model of human disease. Multiple myeloma.

1988 • 183 citations

The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow.

1995 • 171 citations

The Development of a Model for the Homing of Multiple Myeloma Cells to Human Bone Marrow

1997 • 163 citations

Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse

1997 • 155 citations

Characterization of adhesion molecules on human myeloma cell lines

1992 • 150 citations

Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin

1995 • 142 citations

Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma

1989 • 126 citations

A murine model of human myeloma bone disease

1997 • 120 citations

Induction of experimental bone metastasis in mice by transfection of integrin alpha 4 beta 1 into tumor cells.

1996 • 116 citations

Development of an in vivo model of human multiple myeloma bone disease

1996 • 106 citations

Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo.

1993 • 91 citations

Myeloma bone disease

1998 • 73 citations

Vascular cell adhesion molecule-1 and VLA-4 are obligatory adhesion proteins in the heterotypic adherence between human leukemia/lymphoma cells and marrow stromal cells.

1993 • 59 citations

Rescue from apoptosis in early (CD34-selected) versus late (non-CD34-selected) human hematopoietic cells by very late antigen 4- and vascular cell adhesion molecule (VCAM) 1-dependent adhesion to bone marrow stromal cells.

1998 • 54 citations

Differentiation of HL-60 Cells into Cells with the Osteoclast Phenotype*

1991 • 53 citations

Expression of the cell‐adhesion molecule VCAM‐1 by stromal cells is necessary for osteoclastogenesis

1997 • 45 citations

Adhesion molecules involved in the binding of murine myeloma cells to bone marrow stromal elements

1995 • 42 citations

Differential Use of Very Late Antigen-4 and -5 Integrins by Hematopoietic Precursors and Myeloma Cells to Adhere to Transforming Growth Factor-β1-treated Bone Marrow Stroma

1998 • 34 citations

Contact Between Human Bone Marrow Stromal Cells and B Lymphocytes Enhances Very Late Antigen-4/Vascular Cell Adhesion Molecule-1–Independent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and ERK2 in Stromal Cells

1997 • 29 citations

Parathyroid Hormone-Related Protein mRNA and Protein Expression in Multiple Myeloma: A Case Report

1998 • 20 citations

Production and characterisation of monoclonal antibodies to parathyroid hormone-related protein

1990 • 11 citations

Analysis of the activation state of α4β1 integrin in human B cell lines derived from myeloma, leukemia or lymphoma

1997 • 11 citations

Chinese Hamster Ovary Cells Expressing α4β1 Integrin Stimulate Osteoclast Formation In Vitro

1998 • 9 citations

Allele-specific inactivation of the α4 integrin gene expression in fibrosarcoma cell lines and relevance for spontaneous metastasis

1998 • 8 citations