B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE)

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application

1990 • 590 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

1982 • 421 citations

Dubois' Lupus Erythematosus

1994 • 360 citations

Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.

1983 • 353 citations

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.

1992 • 342 citations

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

1981 • 334 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

The costimulatory function of antigen-presenting cells

1990 • 304 citations

Molecular Events Mediating T Cell Activation

1990 • 303 citations

B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas.

1982 • 297 citations

The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

1992 • 273 citations

Functional expression of B7/BB1 on activated T lymphocytes.

1993 • 271 citations

Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in rat experimental crescentic glomerulonephritis.

1993 • 214 citations

B7, a B-cell-restricted antigen that identifies preactivated B cells.

1987 • 211 citations

Dissection of an inflammatory process induced by CD8+ T cells

1990 • 187 citations

Soluble interleukin‐2 receptors in systemic lupus erythematosus

1988 • 170 citations

The lupus activity criteria count (LACC).

1984 • 165 citations

Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus.

1988 • 162 citations

Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus

1984 • 159 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus

1990 • 140 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.

1992 • 118 citations

The interleukin 2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells.

1986 • 111 citations

Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis.

1989 • 100 citations

The role of interleukin 2 in autoimmunity

1989 • 89 citations

A Simple Severity of Disease Index for Systemic Lupus Erythematosus

1993 • 70 citations

Direct helper T cell‐induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7

1991 • 65 citations

In vitro correction of the interleukin 2 defect of autoimmune mice

1983 • 60 citations

OVERVIEW OF CELLULAR IMMUNE FUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS

2004 • 52 citations

HLA-DP+ T cells and deficient interleukin-2 production in patients with systemic lupus erythematosus

1990 • 44 citations

Systemic Lupus Erythematosus

1993 • 43 citations

Lpr T cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis.

1988 • 38 citations

Defective CD2 pathway T cell activation in systemic lupus erythematosus

1991 • 31 citations

Enhanced CD3‐mediated T lymphocyte proliferation in patients with systemic lupus erythematosus

1991 • 31 citations

Impaired generation of polyclonal T cell-mediated cytolytic activity despite normal polyclonal T cell proliferation in systemic lupus erythematosus

1992 • 29 citations

Deficient phytohemagglutinin‐induced interleukin‐2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate

1988 • 28 citations

Interleukin‐1‐Mediated phospholipid breakdown and arachidonic acid release in human synovial cells

1993 • 22 citations

Low responsiveness to the anti Leu 4 antibody by T cells from patients with active systemic lupus erythematosus.

1989 • 10 citations

Pathogenesis of human systemic lupus erythematosus

1992 • 7 citations

Responsiveness of systemic lupus erythematosus T cells to signals provided through LCA T200 (CD45) and T1 (CD5) antigens.

1989 • 4 citations