Epithelial-mesenchymal interactions in the pathogenesis of asthma

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma

1985 • 1,315 citations

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

1989 • 1,151 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Bronchial Biopsies in Asthma: An Ultrastructural, Quantitative Study and Correlation with Hyperreactivity

1989 • 973 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Lung biology in health and disease

1977 • 770 citations

Airway remodeling in asthma

1999 • 708 citations

Myofibroblasts and Subepithelial Fibrosis in Bronchial Asthma

1990 • 670 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

How much asthma is really attributable to atopy?

1999 • 647 citations

Cytokines in asthma

1999 • 646 citations

Eosinophil-associated TGF- β₁mRNA Expression and Airways Fibrosis in Bronchial Asthma

1997 • 639 citations

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1999 • 610 citations

The epidemic of allergy and asthma

1999 • 597 citations

Epidermal growth factor system regulates mucin production in airways

1999 • 573 citations

Involvement of the epidermal growth factor receptor in epithelial repair in asthma

2000 • 506 citations

Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung.

1993 • 482 citations

SMADs: mediators and regulators of TGF-β signaling

1998 • 476 citations

Role of transcription factors in inflammatory lung diseases

1998 • 455 citations

IL-4 Induces Mucin Gene Expression and Goblet Cell Metaplasia In Vitro and In Vivo

1999 • 453 citations

Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid

1998 • 441 citations

Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

1998 • 422 citations

Transforming Growth Factor- β 1 in Asthma

1997 • 416 citations

Effects of Th2 Cytokines on Chemokine Expression in the Lung: IL-13 Potently Induces Eotaxin Expression by Airway Epithelial Cells

1999 • 397 citations

Airways Remodeling Is a Distinctive Feature of Asthma and Is Related to Severity of Disease

1997 • 396 citations

Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.

1998 • 353 citations

Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression.

1996 • 350 citations

Dust Mite Proteolytic Allergens Induce Cytokine Release from Cultured Airway Epithelium

1998 • 327 citations

Interleukin-4 and lnterleukin-13: Their Similarities and Discrepancies

1998 • 324 citations

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

1998 • 314 citations

Corticosteroid reversibility in COPD is related to features of asthma.

1997 • 302 citations

IL-4 Induces Eotaxin: A Possible Mechanism of Selective Eosinophil Recruitment in Helminth Infection and Atopy

1998 • 301 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Proinflammatory and Immunoregulatory Functions of Interleukin-12

1998 • 283 citations

UV activates growth factor receptors via reactive oxygen intermediates.

1996 • 281 citations

Asthma; physiology, immunopharmacology and treatment

1986 • 273 citations

Pulmonary fibrosis: cytokines in the balance

1998 • 272 citations

On the mechanism of mucosal folding in normal and asthmatic airways

1997 • 269 citations

Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls

1992 • 264 citations

Bronchial Subepithelial Fibrosis Correlates With Airway Responsiveness to Methacholine

1997 • 254 citations

The Shedding of the Mucosa of the Bronchial Tree in Asthma

1962 • 252 citations

The polymorphisms S503P and Q576R in the interleukin‐4 receptor α gene are associated with atopy and influence the signal transduction

1999 • 248 citations

Th1- and Th2-Type Cytokines Regulate the Expression and Production of Eotaxin and RANTES by Human Lung Fibroblasts

1999 • 235 citations

Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma.

1999 • 221 citations

Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma

1999 • 219 citations

Expression of Epidermal Growth Factor and Epidermal Growth Factor Receptor Immunoreactivity in the Asthmatic Human Airway

1998 • 218 citations

Expression of growth factors and remodelling of the airway wall in bronchial asthma

1998 • 217 citations

Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma☆☆☆

1999 • 217 citations

Airway Hyperresponsiveness, Increased Intracellular Spaces of Bronchial Epithelium, and Increased Infiltration of Eosinophils and Lymphocytes in Bronchial Mucosa in Asthma

1992 • 211 citations

Reversing the trend: Reducing the prevalence of asthma

1999 • 200 citations

Epithelial-Mesenchymal Interactions in Lung Development

1994 • 196 citations

IL-12–induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor

1999 • 195 citations

Antihistamines in urticaria

1999 • 192 citations

Impaired Lung Branching Morphogenesis in the Absence of Functional EGF Receptor

1997 • 188 citations

IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts

1998 • 186 citations

Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

1997 • 186 citations

Pathogenesis of Liver Fibrosis

1997 • 176 citations

The Attenuated Fibroblast Sheath of the Respiratory Tract Epithelial–Mesenchymal Trophic Unit

1999 • 165 citations

Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.

1999 • 158 citations

Increased Expression of Interleukin-16 in Bronchial Mucosa of Subjects with Atopic Asthma

1997 • 157 citations

The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects.

1992 • 157 citations

Specific Binding of Endothelin on Human Bronchial Smooth Muscle Cells in Culture and Secretion of Endothelin-like Material from Bronchial Epithelial Cells

1990 • 140 citations

The Development of Large and Small Airways

1998 • 139 citations

Apoptosis, Proliferation, and Expression of Bcl-2, Fas, and Fas Ligand in Bronchial Biopsies from Asthmatics

1998 • 139 citations

Differential Monocyte Chemoattractant Protein-1 and Chemokine Receptor 2 Expression by Murine Lung Fibroblasts Derived from Th1- and Th2-Type Pulmonary Granuloma Models

1999 • 138 citations

Airway epithelium expresses interleukin-18

1999 • 134 citations

Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa

1987 • 128 citations

Airway wall remodeling after cessation of exposure to isocyanates in sensitized asthmatic subjects.

1995 • 125 citations

Human CD38 ligand. A 120-KDA protein predominantly expressed on endothelial cells.

1996 • 121 citations

Immunolocalization of protease‐activated receptor‐2 in skin: receptor activation stimulates interleukin‐8 secretion by keratinocytes in vitro

1998 • 120 citations

Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor

1997 • 119 citations

Differences and similarities between chronic obstructive pulmonary disease and asthma

1999 • 115 citations

Cutting Edge: Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE Synthesis

1999 • 114 citations

Morphological integrity of the bronchial epithelium in mild asthma.

1990 • 112 citations

The epidermal growth factor receptor and its ligand family: their potential role in repair and remodelling in asthma.

1999 • 111 citations

The paradigm of type 1 and type 2 antigen‐presenting cells. Implications for atopic allergy

1999 • 106 citations

Death From Asthma in Children

1965 • 104 citations

Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro☆☆☆★★★

1998 • 104 citations

Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchitics.

1994 • 102 citations

Respiratory Epithelial Cell Expression of Vascular Cell Adhesion Molecule-1 and Its Up-regulation by Rhinovirus Infection via NF-κB and GATA Transcription Factors

1999 • 100 citations

EGF and TGF alpha influence in vitro lung development by the induction of matrix-degrading metalloproteinases.

1991 • 96 citations

Spatial and temporal differences in fibroblast behavior in fetal rat lung

1991 • 94 citations

Interleukin-5 Production by Human Airway Epithelial Cells

1999 • 93 citations

Endothelin-1-induced Bronchoconstriction in Asthma

1997 • 93 citations

Expression of CD44 isoforms is increased in the airway epithelium of asthmatic subjects.

1997 • 92 citations

c-fos Proto-oncogene Expression in Bronchial Biopsies of Asthmatics

1992 • 89 citations

Tissue Inhibitor of Metalloproteinase-1 Levels in Bronchoalveolar Lavage Fluid from Asthmatic Subjects

1999 • 89 citations

Differences between Cytokine Release from Bronchial Epithelial Cells of Asthmatic Patients and Non–Asthmatic Subjects: Effect of Exposure to Diesel Exhaust Particles

1999 • 86 citations

Airway epithelial repair: breathtakingly quick and multipotentially pathogenic

1997 • 86 citations

Aetiology of asthma: lessons from lung transplantation

1993 • 85 citations

Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells.

1996 • 83 citations

Interaction with Secretory Component Stimulates Effector Functions of Human Eosinophils But Not of Neutrophils

1998 • 80 citations

Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis

1995 • 78 citations

Inhibition of inducible nitric oxide synthase expression by interleukin‐4 and interleukin‐13 in human lung epithelial cells

1996 • 63 citations

Inflammatory mechanisms in childhood asthma

1998 • 63 citations

Heat shock protein 70 upregulation is related to HLA‐DR expression in bronchial asthma. Effects of inhaled glucocorticoids

1998 • 63 citations

In vitro procollagen synthesis and proliferative phenotype of bronchial fibroblasts from normal and asthmatic subjects.

1998 • 63 citations

CYTOKINE PRODUCTION BY CELL CULTURES FROM BRONCHIAL SUBEPITHELIAL MYOFIBROBLASTS

1996 • 59 citations

Growth factors accelerate epithelial repair in sheep trachea

1993 • 57 citations

Role of respiratory infection in onset of asthma and chronic obstructive pulmonary disease

1999 • 55 citations

Epithelial barrier formation by airway basal cells

1997 • 50 citations

Interferon gamma induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells.

1997 • 47 citations

Maternal programming in asthma and allergy

1998 • 44 citations

The distribution of adhesive mechanisms in the normal bronchial epithelium

1993 • 44 citations

Immunohistochemical analysis of the activation of NF‐κB and expression of associated cytokines and adhesion molecules in human models of allergic inflammation

1999 • 42 citations

Intestinal subepithelial myofibroblasts and mucosal immunophysiology

1994 • 42 citations

Unique role of allergens and the epithelium in asthma

1998 • 41 citations

Oxidants affect permeability and repair of the cultured human tracheal epithelium

1995 • 40 citations

A CD28-Associated Signaling Pathway Leading to Cytokine Gene Transcription and T Cell Proliferation Without TCR Engagement

1998 • 39 citations

Interleukin‐4 and interferon‐γ synergistically increase secretory component gene expression, but are additive in stimulating secretory immunoglobulin A release by Calu‐3 airway epithelial cells

1999 • 39 citations

Immunohistochemical analysis of the activation of NF-?B and expression of associated cytokines and adhesion molecules in human models of allergic inflammation

1999 • 33 citations

Attenuated Fibroblast Sheath around the Basement Membrane Zone in the Trachea

1993 • 33 citations

Objective quantitative analysis of eosinophils and bronchial epithelial cells in induced sputum by laser scanning cytometry

1999 • 32 citations

Regulation of Epithelial Proliferation by TGF‐β

2007 • 31 citations

Transforming growth factor-β (TGF-β) type I and type II receptors are both required for TGF-β-mediated extracellular matrix production in lung fibroblasts

1999 • 30 citations

Increased CD44 expression in human bronchial epithelial repair after damage or plating at low cell densities

2000 • 27 citations

Inflammatory Mechanisms in Asthma

2021 • 20 citations

Immunopathology Of Lung Disease

1996 • 17 citations

Epidermal growth factor-like molecular species in normal bronchoalveolar lavage fluid

1996 • 10 citations

Which is the true regulator of TH₂ cell development in allergic immune responses?

1998 • 8 citations

Bronchial Asthma: Pathophysiology

1973 • 6 citations

Quantitative scores for asthma and atopy

1998 • 5 citations

Deleted Work

1955 • 0 citations

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