A CD28-Associated Signaling Pathway Leading to Cytokine Gene Transcription and T Cell Proliferation Without TCR Engagement

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

1995 • 304 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function

1996 • 229 citations

CD28 signals through acidic sphingomyelinase.

1995 • 194 citations

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1991 • 194 citations

Flow cytometric measurement of cytoplasmic free calcium in human peripheral blood T lymphocytes with fluo-3, a new fluorescent calcium indicator

1990 • 184 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28

1997 • 171 citations

Alterations of the Lymphocyte-Specific Protein Tyrosine Kinase (p56^lck) during T-Cell Activation

1988 • 169 citations

Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells.

1986 • 165 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21^ras

1995 • 155 citations

Transforming Growth Factor β and Cyclosporin A Inhibit the Inducible Activity of the Interleukin-2 Gene in T Cells Through a Noncanonical Octamer-Binding Site

1993 • 148 citations

T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway.

1990 • 147 citations

CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.

1993 • 116 citations

Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.

1994 • 81 citations

p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.

1995 • 80 citations

Activation of src Family Kinase lck Following CD28 Crosslinking in the Jurkat Leukemic Cell Line

1994 • 59 citations

T Cell–Mediated Elimination of B7.2 Transgenic B Cells

1997 • 49 citations

CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca²⁺‐independent costimulatory activity

1994 • 42 citations

Monoclonal antibodies directed to different epitopes in the CD3-TCR complex induce different states of competence in resting human T cells.

1992 • 40 citations

Comparison of CD28‐B7.1 and B7.2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production

1996 • 40 citations

CD28-Mediated Activation of Resting Human T Cells without Costimulation of the CD3/TCR Complex

1997 • 33 citations

CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

1992 • 24 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 21 citations

Differential Phosphorylation of the T Lymphocyte Costimulatory Receptor CD28

1996 • 21 citations

The generation of memory antigen‐specific cytotoxic T cell responses by CD28/CD80 interactions in the absence of antigen

1997 • 17 citations