Structure/function relationships in nickel metallobiochemistry

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Biochemistry of methanogenesis: a tribute to Marjory Stephenson:1998 Marjory Stephenson Prize Lecture

1998 • 1,072 citations

Nonplanar porphyrins and their significance in proteins

1998 • 804 citations

The crystal structure of urease from Klebsiella aerogenes

1995 • 795 citations

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

1991 • 720 citations

Structure of the [NiFe] Hydrogenase Active Site: Evidence for Biologically Uncommon Fe Ligands

1996 • 657 citations

Biomimetic Oxidations Catalyzed by Transition Metal Complexes

2000 • 646 citations

Crystal Structure of Methyl-Coenzyme M Reductase: The Key Enzyme of Biological Methane Formation

1997 • 570 citations

Bioinorganic catalysis

1999 • 523 citations

A novel nickel-containing superoxide dismutase from Streptomyces spp

1996 • 422 citations

70 Years of Crystalline Urease: What Have We Learned?

1997 • 371 citations

Carcinogenic Nickel Silences Gene Expression by Chromatin Condensation and DNA Methylation: a New Model for Epigenetic Carcinogens

1995 • 364 citations

The histone fold: a ubiquitous architectural motif utilized in DNA compaction and protein dimerization.

1995 • 351 citations

X-ray spectroscopic studies of nickel complexes, with application to the structure of nickel sites in hydrogenases

1991 • 318 citations

Carcinogenicity Assessment of Selected Nickel Compounds

1997 • 292 citations

The nik operon of Escherichia coli encodes a periplasmic binding‐protein‐dependent transport system for nickel

1993 • 266 citations

Differential expression of hydrogenase isoenzymes in Escherichia coli K-12: evidence for a third isoenzyme

1985 • 260 citations

Crystal structure of human glyoxalase I_evidence for gene duplication and 3D domain swapping

1997 • 232 citations

Molecular Mechanisms of Nickel Carcinogenesis

1991 • 214 citations

Structures of Cys319 Variants and Acetohydroxamate-Inhibited Klebsiella aerogenes Urease^,

1997 • 206 citations

Nickel transport systems in microorganisms

2000 • 203 citations

Transition Metals in Microbial Metabolism

1997 • 185 citations

Isolation and Characterization of the nikR Gene Encoding a Nickel-Responsive Regulator in Escherichia coli

1999 • 178 citations

Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms

1999 • 164 citations

Regulation of High Affinity Nickel Uptake in Bacteria

2000 • 162 citations

Examination of the Nickel Site Structure and Reaction Mechanism in Streptomyces seoulensis Superoxide Dismutase

1999 • 162 citations

Nickel compounds are novel inhibitors of histone H4 acetylation.

2000 • 159 citations

Requirement of Carbon Dioxide for in Vitro Assembly of the Urease Nickel Metallocenter

1995 • 149 citations

Mechanism of H−H Activation by Nickel−Iron Hydrogenase

1998 • 149 citations

Purification and characterization of Klebsiella aerogenes UreE protein: A nickel‐binding protein that functions in urease metallocenter assembly

1993 • 142 citations

Purified Methyl‐Coenzyme‐M Reductase is Activated when the Enzyme‐Bound Coenzyme F430 is Reduced to the Nickel(I) Oxidation State by Titanium(III) Citrate

1997 • 130 citations

Unique Isozymes of Superoxide Dismutase inStreptomyces griseus

1996 • 130 citations

The complex of Bacillus pasteurii urease with β-mercaptoethanol from X-ray data at 1.65-Å resolution

1998 • 125 citations

Crystal Structure of the Escherichia coli Peptide Deformylase^,

1997 • 125 citations

Control of peptide deformylase activity by metal cations 1 1Edited by A. R. Fersht

1998 • 125 citations

Active sites of transition-metal enzymes with a focus on nickel

1998 • 124 citations

Peptide Deformylase: A New Type of Mononuclear Iron Protein

1997 • 123 citations

Overproduction and Characterization of a Dimeric Non-Zinc Glyoxalase I from Escherichia coli: Evidence for Optimal Activation by Nickel Ions^,

1998 • 121 citations

In vivo nickel insertion into the carbon monoxide dehydrogenase of Rhodospirillum rubrum: molecular and physiological characterization of cooCTJ

1997 • 121 citations

HypB protein of Bradyrhizobium japonicum is a metal-binding GTPase capable of binding 18 divalent nickel ions per dimer.

1995 • 118 citations

Characterization of UreG, identification of a UreD-UreF-UreG complex, and evidence suggesting that a nucleotide-binding site in UreG is required for in vivo metallocenter assembly of Klebsiella aerogenes urease

1997 • 110 citations

An Escherichia coli hydrogenase‐3‐type hydrogenase in methanogenic archaea

1998 • 110 citations

Transcriptional and post‐transcriptional regulation by nickel of sodN gene encoding nickel‐containing superoxide dismutase from Streptomyces coelicolor Müller

1998 • 109 citations

Nature of the C-Cluster in Ni-Containing Carbon Monoxide Dehydrogenases

1996 • 109 citations

Interaction of the Hydrogenase Accessory Protein HypC with HycE, the Large Subunit of Escherichia coli Hydrogenase 3 during Enzyme Maturation

1998 • 107 citations

Methylation of Carbon Monoxide Dehydrogenase fromClostridium thermoaceticumand Mechanism of Acetyl Coenzyme A Synthesis

1997 • 105 citations

Interaction of Ni(II) and Cu(II) with a metal binding sequence of histone H4: AKRHRK, a model of the H4 tail

2000 • 102 citations

Nickel biochemistry

1998 • 101 citations

Structure of Peptide Deformylase and Identification of the Substrate Binding Site

1998 • 94 citations

Solution structure of nickel-peptide deformylase 1 1Edited by A. R. Fersht

1998 • 92 citations

A Multinuclear ENDOR Study of the C-Cluster in CO Dehydrogenase from Clostridium thermoaceticum: Evidence for H_xO and Histidine Coordination to the [Fe₄S₄] Center

1998 • 90 citations

Interactions of Nickel(II) with Histones: Interactions of Nickel(II) with CH₃CO-Thr-Glu-Ser-His-His-Lys-NH₂, a Peptide Modeling the Potential Metal Binding Site in the “C-Tail” Region of Histone H2A

1998 • 89 citations

Purification and Characterization of the Periplasmic Nickel‐Binding Protein NikA of Escherichia coli K12

1995 • 88 citations

Function of H 2 -forming methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautotrophicum in coenzyme F 420 reduction with H 2

1998 • 87 citations

Purification, characterization, and functional analysis of a truncated Klebsiella aerogenes UreE urease accessory protein lacking the histidine-rich carboxyl terminus

1996 • 86 citations

Structural Examination of the Nickel Site inChromatium vinosumHydrogenase: Redox State Oscillations and Structural Changes Accompanying Reductive Activation and CO Binding

2000 • 86 citations

Identification of Metal-Binding Residues in the Klebsiella aerogenes Urease Nickel Metallochaperone, UreE

1999 • 83 citations

The HypB protein from Bradyrhizobium japonicum can store nickel and is required for the nickel‐dependent transcriptional regulation of hydrogenase

1997 • 81 citations

Conserved Residues and Motifs in the NixA Protein ofHelicobacter pylori Are Critical for the High Affinity Transport of Nickel Ions

1998 • 81 citations

Structure of the Dinuclear Active Site of Urease. X-ray Absorption Spectroscopic Study of Native and 2-Mercaptoethanol-Inhibited Bacterial and Plant Enzymes

1994 • 79 citations

Metallocenter assembly in nickel-containing enzymes

1997 • 79 citations

Unusual Organization of the Genes Coding for HydSL, the Stable [NiFe]Hydrogenase in the Photosynthetic Bacterium Thiocapsa roseopersicina BBS

1998 • 76 citations

Structures and Catalytic Activities of Carboxylate-Bridged Dinickel(II) Complexes as Models for the Metal Center of Urease

1997 • 73 citations

Purification and Characterization of the Periplasmic Nickel-Binding Protein NikA of Escherichia coli K12

1995 • 72 citations

Characterization of the active site of a hydrogen sensor from Alcaligenes eutrophus

1998 • 72 citations

Streptomyces seoulensis sp. nov.

1997 • 71 citations

Mössbauer and EPR Study of the Ni-Activated α-Subunit of Carbon Monoxide Dehydrogenase from Clostridium thermoaceticum

1997 • 67 citations

Two membrane anchors of Wolinella succinogenes hydrogenase and their function in fumarate and polysulfide respiration

1998 • 66 citations

Metal Ion Interactions with Urease and UreD-Urease Apoproteins

1996 • 66 citations

Role of the [4Fe-4S] Cluster in Reductive Activation of the Cobalt Center of the Corrinoid Iron−Sulfur Protein from Clostridium thermoaceticum during Acetate Biosynthesis

1998 • 66 citations

Transcriptional regulation of hydrogenase synthesis by nickel in Bradyrhizobium japonicum.

1990 • 62 citations

HupUV proteins of Rhodobacter capsulatus can bind H2: evidence from the H-D exchange reaction

1997 • 61 citations

The Identification, Purification, and Characterization of CooJ

1998 • 61 citations

Interactions of Nickel(II) with Histones. Stability and Solution Structure of Complexes with CH3CO-Cys-Ala-Ile-His-NH2, a Putative Metal Binding Sequence of Histone H3

1995 • 60 citations

Subforms and In Vitro Reconstitution of the NAD-Reducing Hydrogenase of Alcaligenes eutrophus

1998 • 58 citations

Spectroscopic, Redox, and Structural Characterization of the Ni-Labile and Nonlabile Forms of the Acetyl-CoA Synthase Active Site of Carbon Monoxide Dehydrogenase

1998 • 57 citations

Activation of Methyl-SCoM Reductase to High Specific Activity after Treatment of Whole Cells with Sodium Sulfide

1998 • 55 citations

Nickel-iron hydrogenases: Structural and functional properties

1988 • 53 citations

Mechanism of Carbon Monoxide Oxidation by the Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase from Clostridium thermoaceticum: Kinetic Characterization of the Intermediates

1997 • 52 citations

In vivo and in vitro nickel-dependent processing of the [NiFe] hydrogenase in Azotobacter vinelandii

1994 • 51 citations

A Ni2+ Binding Motif Is the Basis of High Affinity Transport of the Alcaligenes eutrophus Nickel Permease

1997 • 50 citations

Chemical Rescue of Klebsiella aerogenes Urease Variants Lacking the Carbamylated-Lysine Nickel Ligand^,

1998 • 50 citations

Redox-Dependent Acetyl Transfer Partial Reaction of the Acetyl-CoA Decarbonylase/Synthase Complex: Kinetics and Mechanism

1998 • 49 citations

Structural study of the response regulator HupR from Rhodobacter capsulatus. electron microscopy of two-dimensional crystals on a nickel-chelating lipid

1997 • 47 citations

Common cis-acting region responsible for transcriptional regulation of Bradyrhizobium japonicum hydrogenase by nickel, oxygen, and hydrogen

1991 • 45 citations

Variable-temperature magnetic circular dichroism spectroscopy as a probe of the electronic and magnetic properties of nickel in jack bean urease

1991 • 43 citations

Expression and Regulation of the sodF Gene Encoding Iron- and Zinc-Containing Superoxide Dismutase in Streptomyces coelicolor Müller

1998 • 41 citations

Nickel in F430

2007 • 37 citations

C‐Terminal Extension of the H₂‐Activating Subunit, HoxH, Directs Maturation of the NAD‐Reducing Hydrogenase in Alcaligenes Eutrophus

1997 • 35 citations

Spectroscopic characterization of metal binding by Klebsiella aerogenes UreE urease accessory protein

1998 • 35 citations

Biological Nickel

2007 • 32 citations

X-ray absorption spectroscopic evidence for binding of the competitive inhibitor 2-mercaptoethanol to the nickel sites of Jack bean urease. A new nickel-nickel interaction in the inhibited enzyme

1990 • 32 citations

Rhodobacter capsulatus HypF is involved in regulation of hydrogenase synthesis through the HupUV proteins

1998 • 31 citations

Substitution of Valine for Histidine 265 in Carbon Monoxide Dehydrogenase from Rhodospirillum rubrum Affects Activity and Spectroscopic States

1998 • 31 citations

Nucleotide sequences of two hydrogenase-related genes (hypA and hypB) from Bradyrhizobium japonicum, one of which (hypB) encodes an extremely histidine-rich region and guanine nucleotide-binding domains

1994 • 30 citations

CO/CO₂ Potentiometric Titrations of Carbon Monoxide Dehydrogenase from Clostridium thermoaceticum and the Effect of CO₂

1998 • 27 citations

Structural bases for the catalytic mechanism of NiFe hydrogenase

1998 • 25 citations

Models of Superoxide Dismutases

2000 • 25 citations

The structure and function of nickel sites in metalloproteins

2006 • 23 citations

The role of nickel in acetyl-CoA synthesis by the bifunctional enzyme CO dehydrogenase/acetyl-CoA synthase: enzymology and model chemistry

1996 • 19 citations

Substitution of the Urease Active Site Carbamate by Dithiocarbamate and Vanadate

1997 • 17 citations

An X-ray Absorption Spectroscopic Structural Investigation of the Nickel Site inEscherichia coliNikA Protein

1998 • 15 citations

Crystallization and Preliminary X-ray Diffraction Study of the Nickel-binding Protein NikA of Escherichia coli

1994 • 13 citations

A conformational analysis study of a nickel(II) enzyme: urease

1997 • 13 citations

Catalysis by Nickel in Biological Systems

1999 • 4 citations

A theoretical study of the methyl ligation in tetraaza macrocycle nickel complexes which model the acetyl-CoA synthase active site

1998 • 4 citations

Methane Formation by Methanogenic Bacteria: Redox Chemistry of Coenzyme F430

2024 • 3 citations

HIGHLY OVERLAPPING 1H NMR SIGNAL ASSIGNMENTS OF 12,13-DIEPIMERIC COENZYME F430 BY THE COMPENSATED ROESY EXPERIMENT

1998 • 2 citations

Deleted Work

1955 • 0 citations