Molecular Mechanisms of Nickel Carcinogenesis

Toxicity and Carcinogenicity of Nickel Compounds

1989 • 324 citations

Cancers of the Lung and Nasal Sinuses in Nickel Workers

1970 • 284 citations

The role of oxidative damage in metal carcinogenicity

1991 • 212 citations

The role of oxidative processes in metal carcinogenesis

1991 • 209 citations

IARC Monographs on the evaluation of carcinogenic risks to humans: Volume 49. Chromium, nickel and welding

1991 • 189 citations

Senescence of Nickel-Transformed Cells by an X Chromosome: Possible Epigenetic Control

1991 • 188 citations

Inhalation Studies of Nickel Sulfide in Pulmonary Carcinogenesis of Rats2

1975 • 148 citations

Cancers of the lung and nasal sinuses in nickel workers: a reassessment of the period of risk.

1977 • 142 citations

Carcinogenic Activity of Particulate Nickel Compounds Is Proportional to Their Cellular Uptake

1980 • 125 citations

Phagocytosis, cellular distribution, and carcinogenic activity of particulate nickel compounds in tissue culture.

1981 • 121 citations

Induction of chromosomal damage in Chinese hamster ovary cells by soluble and particulate nickel compounds: preferential fragmentation of the heterochromatic long arm of the X-chromosome by carcinogenic crystalline NiS particles.

1985 • 118 citations

Induction of trifluorothymidine-resistant mutants by metal ions in L5178Y/TK+/− cells

1980 • 114 citations

Strand breakage and decreased molecular weight of DNA induced by specific metal compounds

1982 • 109 citations

Mutagenicity of metal cations in cultured cells from Chinese hamster

1979 • 101 citations

Assessment of the uptake and mutagenicity of nickel chloride in Salmonella tester strains

1986 • 87 citations

Initiation by nickel acetate and promotion by sodium barbital of renal cortical epithelial tumors in male F344 rats

1990 • 78 citations

Phagocytosis of nickel subsulfide particles during the early stages of neoplastic transformation in tissue culture.

1980 • 77 citations

Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells.

1989 • 76 citations

DNA-Protein cross-links induced by nickel compounds in intact cultured mammalian cells

1985 • 72 citations

Video time-lapse microscopy of phagocytosis and intracellular fate of crystalline nickel sulfide particles in cultured mammalian cells.

1982 • 72 citations

The phagocytosis and transforming activity of crystalline metal sulfide particles are related to their negative surface charge

1982 • 67 citations

Transgenic chinese hamster V79 cell lines which exhibit variable levels of gpt mutagenesis

1990 • 64 citations

Comparisons of carcinogenicities of nickel compounds in rats.

1976 • 63 citations

Effect of magnesium on nickel-induced genotoxicity and cell transformation

1987 • 62 citations

Characterization of DNA‐protein complexes induced in intact cells by the carcinogen chromate

1988 • 59 citations

Analysis of metal-induced DNA lesions and DNA-repair replication in mammalian cells

1984 • 58 citations

Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates

1983 • 50 citations

Pathway of nickel uptake influences its interaction with heterochromatic DNA

1986 • 49 citations

Cytoplasmic dissolution of phagocytized crystalline nickel sulfide particles: A prerequisite for nuclear uptake of nickel

1982 • 49 citations

Nickel-bound chromatin, nucleic acids, and nuclear proteins from kidney and liver of rats treated with nickel carbonate in vivo.

1984 • 47 citations

Models for Respiratory Cancer in Nickel Refinery Workers

1986 • 38 citations

Dissolution half-times of nickel compounds in water, rat serum, and renal cytosol

1982 • 38 citations

Effects of nickel(II) on nuclear protein binding to DNA in intact mammalian cells.

1987 • 34 citations

Influence of surface charge and dissolution on the selective phagocytosis of potentially carcinogenic particulate metal compounds.

1983 • 33 citations

Specific nickel compounds as carcinogens

1982 • 30 citations

Surface reduction of amorphous NiS particles potentiates their phagocytosis and subsequent induction of morphological transformation in Syrian hamster embryo cells

1982 • 29 citations

Effects of essential divalent metals on carcinogenicity and metabolism of nickel and cadmium

1987 • 27 citations

Modification by simetryn sulphoxide of a specific thiol group in rat haemoglobin

1981 • 25 citations

Toxicity and Carcinogenicity of Essential and Non-essential Metals

1984 • 25 citations

Mutagenic effect of some metal compounds on cultured mammalian cells

1978 • 24 citations

Molecular basis for the activity of nickel.

1984 • 21 citations

Differences in surface properties of amorphous and crystalline metal sulfides may explain their toxicological potency

1981 • 20 citations

Effect of nickel(II) on DNA‐protein binding, thymidine incorporation, and sedimentation pattern of chromatin fractions from intact mammalian cells

1987 • 17 citations

Sequential events in the induction of transformation in cell culture by specific nickel compounds

1983 • 13 citations

Normal human colon cells suppress malignancy when fused with colon cancer cells

1990 • 8 citations