High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Epigenomics of Cancer

2007 • 4,239 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Cancer epigenomics: DNA methylomes and histone-modification maps

2007 • 2,076 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

The power and the promise of DNA methylation markers

2003 • 1,544 citations

DNA methylation in cancer: too much, but also too little

2002 • 1,509 citations

Induction of Tumors in Mice by Genomic Hypomethylation

2003 • 1,479 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

COBRA: a sensitive and quantitative DNA methylation assay

1997 • 1,184 citations

Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L

2004 • 1,130 citations

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

2000 • 1,073 citations

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

2004 • 998 citations

DNA hypomethylation and human diseases

2006 • 778 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Analysis of repetitive element DNA methylation by MethyLight

2005 • 692 citations

The epigenetic regulation of mammalian telomeres

2007 • 653 citations

Aberrant promoter methylation of multiple genes in non-small cell lung cancers.

2001 • 607 citations

Gene-promoter hypermethylation as a biomarker in lung cancer

2004 • 522 citations

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

2000 • 494 citations

Detection and interpretation of altered methylation patterns in cancer cells

2005 • 482 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Lsh, a member of the SNF2 family, is required for genome-wide methylation

2001 • 372 citations

Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers

2006 • 320 citations

MIRA-Assisted Microarray Analysis, a New Technology for the Determination of DNA Methylation Patterns, Identifies Frequent Methylation of Homeodomain-Containing Genes in Lung Cancer Cells

2006 • 289 citations

Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay

2007 • 283 citations

LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability

2007 • 259 citations

Genome-wide Hypomethylation in Human Glioblastomas Associated with Specific Copy Number Alteration, Methylenetetrahydrofolate Reductase Allele Status, and Increased Proliferation

2006 • 225 citations

Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family

2005 • 223 citations

Tissue-specific differences in DNA methylation in various mammals

1983 • 204 citations

Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer

2005 • 200 citations

Promoter-Dependent Mechanism Leading to Selective Hypomethylation within the 5′ Region of Gene MAGE-A1 in Tumor Cells

2004 • 189 citations

5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result

1979 • 182 citations

Detection of Promoter Hypermethylation of Multiple Genes in the Tumor and Bronchoalveolar Lavage of Patients with Lung Cancer

2004 • 169 citations

Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling

2003 • 160 citations

CpG island methylation and expression of tumour-associated genes in lung carcinoma

2005 • 148 citations

Methylation of reiterated sequences in mammalian DNAs Effects of the tissue type, age, malignancy and hormonal induction

1981 • 140 citations

Lsh, an epigenetic guardian of repetitive elements

2004 • 138 citations

Promoter hypermethylation of tumor suppressor and tumor‐related genes in non‐small cell lung cancers

2003 • 137 citations

High-Density Single Nucleotide Polymorphism Array Defines Novel Stage and Location-Dependent Allelic Imbalances in Human Bladder Tumors

2005 • 85 citations

Maintenance and regulation of DNA methylation patterns in mammals

2005 • 80 citations

Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes

1999 • 77 citations

Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia.

2000 • 69 citations

Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers

2004 • 57 citations

Tumor‐specific exon creation of the HELLS/SMARCA6 gene in non‐small cell lung cancer

2004 • 33 citations