LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Induction of Tumors in Mice by Genomic Hypomethylation

2003 • 1,479 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

CpG island methylator phenotype in cancer

2004 • 1,052 citations

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

2004 • 998 citations

The 5-methylcytosine content of DNA from human tumors

1983 • 835 citations

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.

1999 • 475 citations

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

2000 • 462 citations

Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis

2004 • 411 citations

Lsh, a member of the SNF2 family, is required for genome-wide methylation

2001 • 372 citations

Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage

2006 • 267 citations

DNA Methylation Changes after 5-Aza-2′-Deoxycytidine Therapy in Patients with Leukemia

2006 • 260 citations

DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas

1999 • 250 citations

Global loss of imprinting leads to widespread tumorigenesis in adult mice

2005 • 245 citations

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines.

1990 • 237 citations

DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.

1986 • 215 citations

Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR.

1997 • 197 citations

Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer

2004 • 149 citations

Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors

2006 • 137 citations

Epigenetic Changes in Solid and Hematopoietic Tumors

2005 • 133 citations

The Relationship between Global Methylation Level, Loss of Heterozygosity, and Microsatellite Instability in Sporadic Colorectal Cancer

2005 • 120 citations

Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies

1987 • 115 citations

Genetic and epigenetic alterations in carcinogenesis

2000 • 84 citations

The study of aberrant methylation in cancer via restriction landmark genomic scanning

2002 • 74 citations

Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer

2006 • 72 citations

Microarray‐based survey of CpG islands identifies concurrent hyper‐ and hypomethylation patterns in tissues derived from patients with breast cancer

2006 • 45 citations

DNA hypomethylation in Morris hepatomas

1983 • 29 citations

DNA methylase activity of normal liver, regenerating liver, and a transplantable hepatocellular carcinoma.

1981 • 9 citations