Promoter hypermethylation of tumor suppressor and tumor‐related genes in non‐small cell lung cancers

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Cancer burden in the year 2000. The global picture

2001 • 2,206 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

2002 • 1,019 citations

Aberrant promoter methylation of multiple genes in non-small cell lung cancers.

2001 • 607 citations

Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.

1999 • 530 citations

Carcinogenic Nickel Silences Gene Expression by Chromatin Condensation and DNA Methylation: a New Model for Epigenetic Carcinogens

1995 • 364 citations

p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer.

2001 • 327 citations

CpG-Island Methylation in Aging and Cancer

2000 • 302 citations

Smoke exposure, histologic type and geography‐related differences in the methylation profiles of non‐small cell lung cancer

2002 • 286 citations

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.

2002 • 247 citations

Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development.

2001 • 236 citations

DNA methylation profiles of lung tumors.

2001 • 233 citations

Patterns of gene promoter methylation in squamous cell cancer of the head and neck

2002 • 213 citations

Prognostic Significance of K-ras Codon 12 Mutations in Patients With Resected Stage I and II Non–Small-Cell Lung Cancer

1999 • 194 citations

Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia

2000 • 174 citations

Molecular and Genetic Aspects of Lung Cancer

2000 • 163 citations

Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung.

1994 • 161 citations

Changing patterns of lung cancer incidence by histological type.

1991 • 158 citations

Promoter Methylation Status of E-Cadherin, hMLH1, and p16 Genes in Nonneoplastic Gastric Epithelia

2002 • 148 citations

Frequent Aberrant Methylation of p16^INK4a in Primary Rat Lung Tumors

1997 • 146 citations

Promoter hypermethylation of tumor‐related genes in gastric intestinal metaplasia of patients with and without gastric cancer

2002 • 126 citations

Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas

2001 • 113 citations

Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung.

1992 • 107 citations

Hypermethylation of the TSLC1 Gene Promoter in Primary Gastric Cancers and Gastric Cancer Cell Lines

2002 • 65 citations

Frequent Epigenetic Silencing of the p16 Gene in Non‐small Cell Lung Cancers of Tobacco Smokers

2002 • 44 citations

Association between p53 Mutation and Clinicopathological Features of Non-small Cell Lung Cancer

1997 • 11 citations