Induction of COX-2 Expression by Nitric Oxide in Rheumatoid Synovial Cells

Cyclooxygenase in biology and disease

1998 • 2,483 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

1996 • 889 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.

1995 • 487 citations

Role and regulation of cyclooxygenase-2 during inflammation

1999 • 390 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

Co‐induction of nitric oxide synthase and cyclo‐oxygenase: interactions between nitric oxide and prostanoids

1995 • 343 citations

Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients.

1996 • 285 citations

Involvement of nuclear factor kB in the regulation of cyclooxygenase‐2 expression by interleukin‐1 in rheumatoid synoviocytes

1997 • 252 citations

Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells

1993 • 248 citations

Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.

1995 • 217 citations

Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: Differential elevation of cyclooxygenase 2 in inflammatory joint diseases

1998 • 210 citations

Nitric oxide and inflammatory joint diseases

1998 • 176 citations

Pharmacology of Prostaglandin Endoperoxide Synthase Isozymes‐1 and‐2^a

1994 • 168 citations

Nitric oxide synthase and cyclooxygenases

1999 • 167 citations

Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells.

1996 • 158 citations

Increased nitric oxide production accompanied by the up‐regulation of inducible nitric oxide synthase in vascular endothelium from patients with systemic lupus erythematosus

1997 • 153 citations

[2] Interactions of nitric oxide with cyclooxygenase: In vitro, ex vivo, and in vivo studies

1996 • 101 citations

Mechanisms of tissue destruction and cellular activation in rheumatoid arthritis

1992 • 62 citations

Methotrexate and cyclooxygenase metabolism in cultured human rheumatoid synoviocytes.

1998 • 46 citations

Induction of cyclooxygenase-2 in human synovial cells by β2-microglobulin

1999 • 14 citations