Ethanol Triggers Neural Crest Apoptosis through the Selective Activation of a Pertussis Toxin–Sensitive G Protein and a Phospholipase Cβ–Dependent Ca²⁺ Transient

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Regulation of Phosphoinositide-Specific Phospholipase C

2001 • 1,604 citations

Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome

2000 • 1,366 citations

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

1997 • 1,223 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 857 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Fetal Alcohol Syndrome: Embryogenesis in a Mouse Model

1981 • 630 citations

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

1990 • 600 citations

Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor

1997 • 595 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

A Review of the Neurobehavioral Deficits in Children with Fetal Alcohol Syndrome or Prenatal Exposure to Alcohol

1998 • 485 citations

Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.

1985 • 457 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Fyn-Kinase as a Determinant of Ethanol Sensitivity: Relation to NMDA-Receptor Function

1997 • 301 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

2000 • 266 citations

Ethanol opens G-protein-activated inwardly rectifying K+ channels

1999 • 253 citations

G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action

1999 • 241 citations

Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

1992 • 231 citations

Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster

2003 • 226 citations

Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?

1998 • 216 citations

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1996 • 209 citations

Alcohol-induced Purkinje cell loss depends on developmental timing of alcohol exposure and correlates with motor performance

1998 • 184 citations

G PROTEIN SUBUNITS

1997 • 168 citations

Free Radicals and Ethanol-Induced Cytotoxicity in Neural Crest Cells

1996 • 147 citations

Suramin analogues as subtype-selective G protein inhibitors.

1996 • 146 citations

Ethanol‐Induced Neural Crest Apoptosis Is Coincident with Their Endogenous Death, But Is Mechanistically Distinct

1998 • 140 citations

Ethanol Impairs Insulin-stimulated Neuronal Survival in the Developing Brain

2003 • 137 citations

Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells

1997 • 123 citations

βγ Dimers Mediate Synergy of Dopamine D2 and Adenosine A2 Receptor-Stimulated PKA Signaling and Regulate Ethanol Consumption

2002 • 123 citations

G Protein-Coupled Receptor-Mediated Mitogen-Activated Protein Kinase Activation through Cooperation of Gα_q and Gα_i Signals

2000 • 109 citations

A New Mode of Ca2+ Signaling by G Protein-Coupled Receptors

2003 • 92 citations

Microcontrolled release of biologically active compounds in chick embryos: Beads of 200-μm diameter for the local release of retinoids

1984 • 88 citations

Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-βγ dimers

2003 • 84 citations

Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K ⁺ channels

2001 • 79 citations

Crosstalk between Gα _i - and Gα _q -coupled receptors is mediated by Gβγ exchange

1999 • 77 citations

Basic fibroblast growth factor- and platelet-derived growth factor-mediated cell proliferation in B104 neuroblastoma cells: effect of ethanol on cell cycle kinetics

1997 • 72 citations

RhoA and lysophosphatidic acid are involved in the actin cytoskeleton reorganization of astrocytes exposed to ethanol

2003 • 70 citations

G proteins as drug targets

1999 • 68 citations

Octanol Antagonism of Ethanol Teratogenesis

2001 • 64 citations

Spontaneous Calcium Transients Are Required for Neuronal Differentiation of Murine Neural Crest

1999 • 62 citations

Avian Genetic Background Modulates the Neural Crest Apoptosis Induced by Ethanol Exposure

2000 • 61 citations

Constitutively active Gq/11-coupled Receptors Enable Signaling by Co-expressed Gi/o-coupled Receptors

2004 • 54 citations

Relative expression of Slug, RhoB, and HNK‐1 in the cranial neural crest of the early chicken embryo

2003 • 51 citations

Ethanol‐Induced Cephalic Apoptosis Requires Phospholipase C‐Dependent Intracellular Calcium Signaling

2003 • 47 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 37 citations

D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.

1996 • 34 citations

Effects of Ethanol on Protein Kinase C α Activity Induced by Association with Rho GTPases

2003 • 26 citations

Pertussis toxin-catalyzed ADP-ribosylation of G0.alpha. with mutations at the carboxyl terminus

1992 • 20 citations

Roles of tyrosine kinase–, 1-phosphatidylinositol 3-kinase–, and mitogen-activated protein kinase–signaling pathways in ethanol-induced contractions of rat aortic smooth muscle

2002 • 19 citations

Calcium transient activity in cultured murine neural crest cells is regulated at the IP3 receptor

2000 • 16 citations

Measurement of intracellular calcium and pH in avian neural crest cells.

1990 • 12 citations

Acute Ethanol‐Induced Adenosine Diphosphate Ribosylation Regulates the Functional Activity of Rat Striatal Pertussis Toxin–Sensitive G Proteins

2004 • 3 citations