G Protein-Coupled Receptor-Mediated Mitogen-Activated Protein Kinase Activation through Cooperation of Gα_q and Gα_i Signals

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

G‐protein‐coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G‐protein recognition

1997 • 585 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Bradykinin receptors: Pharmacological properties and biological roles

1992 • 462 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Mitogenic Signaling via G Protein-Coupled Receptors

1996 • 425 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Diversity and Selectivity of Receptor-G Protein Interaction

1996 • 365 citations

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

1991 • 321 citations

FUNCTIONAL AND STRUCTURAL COMPLEXITY OF SIGNAL TRANSDUCTION VIA G-PROTEIN-COUPLED RECEPTORS

1997 • 321 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.

1991 • 288 citations

Embryonic cardiomyocyte hypoplasia and craniofacial defects in Galpha q/Galpha 11-mutant mice

1998 • 238 citations

MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.

1992 • 231 citations

Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gαi

1999 • 227 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

Differential Involvement of Gα12 and Gα13 in Receptor-mediated Stress Fiber Formation

1999 • 209 citations

Adaptor Proteins Grb2 and Crk Couple Pyk2 with Activation of Specific Mitogen-activated Protein Kinase Cascades

1999 • 207 citations

Go-protein α-Subunits Activate Mitogen-activated Protein Kinase via a Novel Protein Kinase C-dependent Mechanism

1996 • 205 citations

Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling

1997 • 204 citations

G Protein-Coupled Receptor Systems Involved in Cell Growth and Oncogenesis

1995 • 196 citations

Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin.

1991 • 160 citations

Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

1998 • 154 citations

Modulation of Rap Activity by Direct Interaction of Gαo with Rap1 GTPase-activating Protein

1999 • 152 citations

Regulation of cell proliferation by G proteins

1998 • 151 citations

Ligand-induced Phosphorylation/Dephosphorylation of the Endogenous Bradykinin B2 Receptor from Human Fibroblasts

1996 • 128 citations

Receptors for bradykinin and related kinins: a critical analysis

1993 • 113 citations

Regulation of Ras·GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester

1999 • 113 citations

Bradykinin B₂ Receptor-Mediated Mitogen-Activated Protein Kinase Activation in COS-7 Cells Requires Dual Signaling via Both Protein Kinase C Pathway and Epidermal Growth Factor Receptor Transactivation

1999 • 109 citations

Mechanisms of MAPK activation by bradykinin in vascular smooth muscle cells

1999 • 103 citations

Bradykinin-induced Internalization of the Human B2Receptor Requires Phosphorylation of Three Serine and Two Threonine Residues at Its Carboxyl Tail

1999 • 102 citations

The Calcitonin Receptor Stimulates Shc Tyrosine Phosphorylation and Erk1/2 Activation

1998 • 90 citations

A Novel Mitogenic Signaling Pathway of Bradykinin in the Human Colon Carcinoma Cell Line SW-480 Involves Sequential Activation of a Gq/11 Protein, Phosphatidylinositol 3-Kinase β, and Protein Kinase Cε

1998 • 89 citations

Regulation of tetradecanoyl phorbol acetate-induced responses in NIH 3T3 cells by GAP, the GTPase-activating protein associated with p21c-ras.

1992 • 84 citations

Dual bradykinin B2 receptor signalling in A431 human epidermoid carcinoma cells: activation of protein kinase C is counteracted by a GS-mediated stimulation of the cyclic AMP pathway

1996 • 65 citations

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor

1995 • 63 citations

The regulation of phospholipase D activity and its role in sn-1,2-diradylglycerol formation in bombesin- and phorbol 12-myristate 13-acetate-stimulated Swiss 3T3 cells

1991 • 62 citations

Differential Regulation of Mitogen-activated Protein Kinase Kinase 4 (MKK4) and 7 (MKK7) by Signaling from G Protein βγ Subunit in Human Embryonal Kidney 293 Cells

1999 • 60 citations

Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors

1999 • 59 citations

G protein βγ subunit activates Ras, Raf, and MAP kinase in HEK 293 cells

1995 • 56 citations

Gi Proteins Use a Novel βγ- and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes

1999 • 52 citations

Subtype-Specific Desensitization of Human Endothelin ET_A and ET_B Receptors Reflects Differential Receptor Phosphorylation

1997 • 51 citations

Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling

1999 • 50 citations

Genetic analysis of mammalian G-protein signalling

1998 • 47 citations

A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the G i family

1990 • 44 citations

Activation of mitogen‐activated protein kinase by the bradykinin B₂ receptor is independent of receptor phosphorylation and phosphorylation‐triggered internalization

1999 • 29 citations

Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.

1998 • 25 citations