Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor

1989 • 1,132 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

Inositol Trisphosphate and Calcium Signaling

1995 • 1,036 citations

Preparation and morphology of sarcoplasmic reticulum terminal cisternae from rabbit skeletal muscle.

1984 • 534 citations

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

1989 • 531 citations

Structure and expression of the rat inositol 1,4,5-trisphosphate receptor.

1990 • 469 citations

Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin.

1988 • 427 citations

Structure of a novel InsP3 receptor.

1991 • 383 citations

Cellular functions of immunophilins

1996 • 365 citations

Ca2+-activated ryanodine binding: mechanisms of sensitivity and intensity modulation by Mg2+, caffeine, and adenine nucleotides.

1987 • 314 citations

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

1995 • 288 citations

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

1992 • 253 citations

Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells

1996 • 182 citations

Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium.

1994 • 173 citations

Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release.

1991 • 171 citations

Heparin inhibits the inositol 1,4,5-trisphosphate-dependent, but not the independent, calcium release induced by guanine nucleotide in vascular smooth muscle

1988 • 153 citations

Immunohistochemical localization of an inositol 1,4,5-trisphosphate receptor, P400, in neural tissue: studies in developing and adult mouse brain

1991 • 124 citations

Intracellular Ca2+ pools in PC12 cells. A unique, rapidly exchanging pool is sensitive to both inositol 1,4,5-trisphosphate and caffeine-ryanodine.

1991 • 123 citations

Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization

1994 • 113 citations

Structures of xestospongin A,B,C and D, novel vasodilativecompounds from marine sponge,

1984 • 100 citations

Involvement of the C-terminus of the inositol 1,4,5-trisphosphate receptor in Ca2+ release analysed using region-specific monoclonal antibodies

1991 • 95 citations

The Human Type 1 Inositol 1,4,5-Trisphosphate Receptor from T Lymphocytes

1995 • 75 citations

Araguspongines B, C, D, E, F, G, H, and J, new vasodilative bis-1-oxaquinolizidine alkaloids from an Okinawan marine sponge, Xestospongia sp.

1989 • 71 citations

Activation of the calcium release channel (ryanodine receptor) by heparin and other polyanions is calcium dependent.

1993 • 68 citations

Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells

1997 • 62 citations

Pharmacologically active substances from southern Pacific marine invertebrates

1986 • 49 citations

Pharmacological properties of histamine receptor subtypes.

1994 • 45 citations

Bradykinin: potential for vascular constriction in the presence of endothelial injury

1993 • 41 citations

Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers

1995 • 37 citations

Structure/function relationships of muscarinic acetylcholine receptors

1993 • 35 citations

Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.

1990 • 33 citations

Two New Alkaloids from Xestospongia sp., a New Caledonian Sponge

1992 • 32 citations

Ethanol inhibits muscarinic receptor-stimulated phosphoinositide metabolism and calcium mobilization in rat primary cortical cultures

1995 • 26 citations

Isolation and X-ray crystal structure of racemic Xestospongin D from the Singapore marine sponge Niphates sp1

1996 • 26 citations

Inhibition of nuclear vesicle fusion by antibodies that block activation of inositol 1,4,5-trisphosphate receptors.

1995 • 23 citations

Conformational Considerations in 1-Oxaquinolizidines Related to the Xestospongin/Araguspongine Family: Reassignment of Stereostructures for Araguspongines B and E

1994 • 21 citations

Cholinergic Dilatation and Constriction of Feline Cerebral Blood Vessels Are Mediated by Stimulation of Phosphoinositide Metabolism via Two Different Muscarinic Receptor Subtypes

1994 • 15 citations

Regulation of inositol 1,4,5-trisphosphate receptors in rat basophilic leukemia cells. I. Multiple conformational states of the receptor in a microsomal preparation

1993 • 14 citations

Involvement of inositol 1,4,5-triphosphate and protein kinase C in thrombin-induced contraction of porcine pulmonary artery

1995 • 8 citations

Inositol 1,4,5-Triphosphate and Protein Kinase C are Involved in Trombin- and Trap-Induced Vascular Smooth Muscle Contraction

1995 • 5 citations

[Ca2+]i effects of bradykinin B2 receptor activation in PC12 cells.

1992 • 2 citations