Does fluorine-18 fluorodeoxyglucose metabolic imaging of tumours benefit oncology?

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method

1979 • 2,396 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations

1985 • 1,604 citations

Neuropsychopharmacology

1990 • 1,545 citations

Quantitation in Positron Emission Computed Tomography

1979 • 1,138 citations

Noninvasive determination of local cerebral metabolic rate of glucose in man

1980 • 928 citations

THE METABOLISM OF TUMORS

1931 • 825 citations

SUV: standard uptake or silly useless value?

1995 • 804 citations

Elevated Levels of Glucose Transport and Transporter Messenger RNA Are Induced by ras or src Oncogenes

1987 • 789 citations

Glucose utilization of cerebral gliomas measured by [ ¹⁸ F] fluorodeoxyglucose and positron emission tomography

1982 • 760 citations

Enzymology of Cancer Cells

1977 • 641 citations

Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction.

1993 • 626 citations

Metabolic monitoring of breast cancer chemohormonotherapy using positron emission tomography: initial evaluation.

1993 • 608 citations

Positron emission tomography in Alzheimer's disease

1986 • 563 citations

A FLUORINATED GLUCOSE ANALOG, 2-FLUORO-2-DEOXY-D-GLUCOSE (F-18)

1980 • 509 citations

Positron Emission Tomography Using [18F] Fluorodeoxyglucose in Brain Tumors A Powerful Diagnostic and Prognostic Tool

1987 • 446 citations

Primary and metastatic breast carcinoma: initial clinical evaluation with PET with the radiolabeled glucose analogue 2-[F-18]-fluoro-2-deoxy-D-glucose.

1991 • 444 citations

Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: preliminary prospective evaluation.

1994 • 428 citations

Enzymology of Cancer Cells

1977 • 420 citations

Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies

1988 • 420 citations

Analysis of Emission Tomographic Scan Data: Limitations Imposed by Resolution and Background

1984 • 414 citations

Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [¹⁸F]Fluorodeoxyglucose and [¹¹C]Deoxyglucose

1985 • 413 citations

Prediction of survival in glioma patients by means of positron emission tomography

1985 • 407 citations

Influence of the blood glucose concentration on FDG uptake in cancer--a PET study.

1993 • 404 citations

The dose uptake ratio as an index of glucose metabolism: useful parameter or oversimplification?

1994 • 394 citations

Evaluation of breast masses and axillary lymph nodes with [F-18] 2-deoxy-2-fluoro-D-glucose PET.

1993 • 381 citations

Positron emission tomography in patients with glioma a predictor of prognosis

1988 • 378 citations

Glucocorticoids Inhibit Glucose Transport in Cultured Hippocampal Neurons and Glia

1990 • 339 citations

Differential diagnosis of lung tumor with positron emission tomography: A prospective study

1991 • 326 citations

High‐ and Low‐Affinity Transport of D‐Glucose from Blood to Brain

1981 • 325 citations

Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.

1982 • 292 citations

Recurrence of colorectal tumors: PET evaluation.

1989 • 273 citations

Comparative localization of foci in partial epilepsy by PCT and EEG

1982 • 270 citations

Positron emission tomography studies in patients with locally advanced and/or metastatic breast cancer: a method for early therapy evaluation?

1995 • 267 citations

Glucose utilizationin vivo by human pulmonary neoplasms

1987 • 267 citations

Florodeoxyglucose imaging: A method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors

1988 • 258 citations

Cancer Detection with Whole-Body PET Using 2-[18F]Fluoro-2-Deoxy-D-Glucose

1993 • 254 citations

Local cerebral glucose utilization in the normal conscious macaque monkey

1978 • 246 citations

PET studies of fluorodeoxyglucose metabolism in patients with recurrent colorectal tumors receiving radiotherapy.

1991 • 245 citations

Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment.

1992 • 245 citations

Standardized uptake values of FDG: body surface area correction is preferable to body weight correction.

1994 • 234 citations

Positron emission tomography with fluorine-18-deoxyglucose in the detection and staging of breast cancer

1993 • 231 citations

Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry.

1991 • 229 citations

PET of malignant cerebral tumors after interstitial brachytherapy

1988 • 216 citations

Positron emission tomography using fluorine-18-fluorodeoxyglucose in malignant lymphoma: a comparison with proliferative activity.

1992 • 215 citations

Noninvasive grading of musculoskeletal tumors using PET.

1991 • 211 citations

Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation

1994 • 211 citations

Effects of Temporal Sampling, Glucose Metabolic Rates, and Disruptions of the Blood—Brain Barrier on the FDG Model with and without a Vascular Compartment: Studies in Human Brain Tumors with PET

1986 • 208 citations

The influence of plasma glucose levels on fluorine-18-fluorodeoxyglucose uptake in bronchial carcinomas.

1993 • 203 citations

In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas

1983 • 203 citations

Detecting recurrent or residual lung cancer with FDG-PET

1995 • 198 citations

Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve.

1993 • 198 citations

The use of FDG-PET in the detection and management of malignant lymphoma: correlation of uptake with prognosis.

1991 • 191 citations

The Application of Positron Emission Tomographie Imaging With Fluorodeoxyglucose to the Evaluation of Breast Disease

1992 • 188 citations

Clinical value of whole-body positron emission tomography with [18F]fluorodeoxyglucose in recurrent colorectal cancer

1994 • 184 citations

Increased glucose metabolism in untreated non-Hodgkin's lymphoma: a study with positron emission tomography and fluorine-18- fluorodeoxyglucose

1995 • 180 citations

Metabolic and hemodynamic evaluation of gliomas using positron emission tomography.

1987 • 180 citations

Recurrent rectal cancer and scar: differentiation with PET and MR imaging.

1992 • 178 citations

Head and neck cancer: detection of recurrence with PET and 2-[F-18]fluoro-2-deoxy-D-glucose.

1995 • 175 citations

Use of positron emission tomography with fluorodeoxyglucose in patients with extracranial head and neck cancers

1994 • 175 citations

Identification of early recurrence of primary central nervous system tumors by [¹⁸F]fluorodeoxyglucose positron emission tomography

1991 • 174 citations

Use of PET Methods for Measurement of Cerebral Energy Metabolism and Hemodynamics in Cerebrovascular Disease

1989 • 166 citations

Initial assessment of positron emission tomography using 2-fluorine-18-fluoro-2-deoxy-D-glucose in the imaging of malignant melanoma.

1993 • 165 citations

High-resolution PET studies in Alzheimer's disease.

1991 • 156 citations

Clinical Value of Pet with ¹⁸F-Fluorodeoxyglucose and L-Methyl-¹¹C-Methionine for Diagnosis of Recurrent Brain Tumor and Radiation Injury

1991 • 152 citations

Fluorodeoxyglucose imaging of advanced head and neck cancer after chemotherapy.

1993 • 149 citations

Validation of PET-acquired input functions for cardiac studies.

1988 • 149 citations

PET evaluation of soft-tissue masses with fluorine-18 fluoro-2-deoxy-D-glucose.

1992 • 143 citations

Positron Emission Tomography in the Detection of Malignant Degeneration of Low-Grade Gliomas

1989 • 136 citations

Preoperative prediction of the outcome of coronary revascularization using positron emission tomography.

1992 • 128 citations

Stability of the potassium content of cerebrospinal fluid and brain

1967 • 126 citations

Parametric images of myocardial metabolic rate of glucose generated from dynamic cardiac PET and 2-[18F]fluoro-2-deoxy-d-glucose studies.

1991 • 125 citations

Noninvasive method to obtain input function for measuring tissue glucose utilization of thoracic and abdominal organs.

1991 • 122 citations

Barbiturates reduce human cerebral glucose metabolism

1986 • 118 citations

Myocardial glucose uptake in patients with insulin-dependent diabetes mellitus assessed quantitatively by dynamic positron emission tomography.

1993 • 117 citations

Imaging of pulmonary mass lesions with whole-body positron emission tomography and fluorodeoxyglucose

1993 • 113 citations

Use of [¹⁸F]fluorodeoxyglucose positron emission tomography in patients with primary malignant brain tumors

1993 • 110 citations

Perfusion and metabolism in predicting the survival of patients with cerebral gliomas

1994 • 109 citations

Positron emission tomographic measurement of blood‐to‐brain and blood‐to‐tumor transport of ⁸²Rb: The effect of dexamethasone and whole‐brain radiation therapy

1985 • 107 citations

Antiepileptic Drugs and Cerebral Glucose Metabolism

1988 • 106 citations

Kinetic, electrophoretic, and chromatographic studies on glucose-ATP phosphotransferases in rat hepatomas.

1969 • 104 citations

Whole-Body Positron Emission Tomography with 2-[18F]-Fluoro-2-deoxy-D-glucose Can Detect Recurrent Ovarian Carcinoma

1993 • 102 citations

Dexamethasone treatment of brain tumor patients

1985 • 100 citations

Determination of malignancy of thyroid nodules with positron emission tomography.

1993 • 99 citations

FDG-PET as a Prognostic Indicator in Radiochemotherapy of Glioblastoma

1993 • 98 citations

Effect of Valproate on Human Cerebral Glucose Metabolism

1991 • 98 citations

FDG-PET in the Selection of Brain Lesions for Biopsy

1991 • 97 citations

Can positron emission tomography (PET) be used to detect subclinical response to cancer therapy?

1995 • 93 citations

Use of the abdominal aorta for arterial input function determination in hepatic and renal PET studies.

1992 • 92 citations

Distinguishing tumor recurrence from irradiation sequelae with positron emission tomography in patients treated for larynx cancer

1994 • 91 citations

Influence of Plasma Glucose Concentration on Lumped Constant of the Deoxyglucose Method: Effects of Hyperglycemia in the Rat

1990 • 87 citations

The effect of carbamazepine on cerebral glucose metabolism

1989 • 87 citations

Reexamination of Glucose-6-Phosphatase Activity in the Brain in Vivo: No Evidence for a Futile Cycle

1985 • 82 citations

Experimental study for cancer diagnosis with positron-labeled fluorinated glucose analogs: [18F]-2-fluoro-2-deoxy-D-mannose: A new tracer for cancer detection

1982 • 81 citations

Errors Introduced by Tissue Heterogeneity in Estimation of Local Cerebral Glucose Utilization with Current Kinetic Models of the [¹⁸F]Fluorodeoxyglucose Method

1992 • 79 citations

Assessment of regional myocardial ischemia by positron-emission computed tomography

1982 • 77 citations

Positron Emission Tomography of Thyroid Masses

1993 • 76 citations

Grading Liposarcomas with PET using [18F]FDG

1990 • 74 citations

Decreased cerebral glucose metabolism in patients with brain tumors: an effect of corticosteroids

1995 • 72 citations

Effect of Phenytoin on Human Cerebral Glucose Metabolism

1986 • 71 citations

In vivo metabolism of childhood posterior fossa tumors and primitive neuroectodermal tumors before and after treatment

1993 • 71 citations

Model of Kinetic Behavior of Deoxyglucose in Heterogeneous Tissues in Brain: A Reinterpretation of the Significance of Parameters Fitted to Homogeneous Tissue Models

1991 • 70 citations

FDG-PET for predicting the prognosis of malignant lymphoma

1994 • 68 citations

Metabolic and clinical correlates of acute ischemic infarction

1987 • 66 citations

Assessment of radiotherapeutic effects on experimental tumors using 18F-2-fluoro-2-deoxy-D-glucose

1986 • 66 citations

The potential of 2-deoxy-2[18F]fluoro-D-glucose (FDG) for the detection of tumor involvement in lymph nodes.

1990 • 66 citations

Glycolytic Rate (PET) and Contrast Enhancement (CT) in Human Cerebral Gliomas

1983 • 65 citations

Fluorine-18-fluorodeoxyglucose PET to determine regional cerebral glucose utilization: a re-examination.

1996 • 60 citations

Metabolic regulation and enzyme alterations in the Morris hepatomas.

1968 • 57 citations

Positron Emission Tomography for Treatment Evaluation and Recurrence Detection Compared with CT in Long-Term Follow-up Cases of Lung Cancer

1992 • 55 citations

Detection of breast cancer in women after augmentation mammoplasty using fluorine-18-fluorodeoxyglucose-PET.

1994 • 49 citations

The Influence of Tissue Heterogeneity on Results of Fitting Nonlinear Model Equations to Regional Tracer Uptake Curves: With an Application to Compartmental Models Used in Positron Emission Tomography

1987 • 47 citations

Satellite PET and lung cancer

1993 • 44 citations

The relevance of positron emission tomography for the diagnosis and treatment of head and neck tumors.

1993 • 41 citations

Determination of the Deoxyglucose and Glucose Phosphorylation Ratio and the Lumped Constant in Rat Brain and a Transplantable Rat Glioma

1989 • 39 citations

A modeling method to improve quantitation of fluorodeoxyglucose uptake in heterogeneous tumor tissue.

1995 • 38 citations

Validity of PET studies in brain tumors.

1990 • 37 citations

Hexokinase isozyme patterns of human uterine tumors

1972 • 35 citations

Quantification of Glucose Utilization in an Experimental Brain Tumor Model by the Deoxyglucose Method

1985 • 31 citations

Metabolism of 2-[18F]fluoro-2-deoxyglucose in tumor-bearing rats: Chromatographic and enzymatic studies

1986 • 29 citations

Differential Diagnosis of Idiopathic Fibrosis from Malignant Lymphadenopathy with PET and F-18 Fluorodeoxyglucose

1992 • 29 citations

Enhanced Detection of Brain Tumors by [18F]Fluorodeoxyglucose PET with Glucose Loading

1994 • 28 citations

The noninvasive assessment of myocardial viability

1993 • 25 citations

Isoenzymes of hexokinase in the developing, normal and neoplastic human brain

1978 • 25 citations

Influence of Size of Regions of Interest on PET Evaluation of Caudate Glucose Consumption

1992 • 24 citations

THE HEXOSE MONOPHOSPHATE PATHWAY IN ETHYLNITROSOUREA INDUCED TUMORS OF THE NERVOUS SYSTEM

1978 • 24 citations

[Recurrence of colorectal tumors].

1988 • 23 citations

Cerebral glucose metabolic rates after 30 and 45 minute acquisitions: a comparative study.

1992 • 22 citations

Uptake of 2-fluoro-2-deoxy-d-[U-14C]-glucose during chemotherapy in murine Lewis lung tumor

1992 • 15 citations

Heterogeneity of regional cerebral glucose metabolism demonstrated in situ in rat brain by 19F NMR rotating frame zeugmatography: One dimensional chemical shift imaging of normal and gliosarcoma implanted brain

1987 • 13 citations

Experimental and clinical study of cancer diagnosis with (F-18) FDG using positron emission tomography

1984 • 6 citations

Local Cerebral Metabolic Changes in Acute Ischemic Strokes

1987 • 5 citations