Structure, Function, and Dynamics of Keratin Intermediate Filaments

Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components

1992 • 650 citations

Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses

1991 • 647 citations

Epidermolysis Bullosa Simplex: Evidence in Two Families for Keratin Gene Abnormalities

1991 • 426 citations

A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering

1992 • 406 citations

Self-assembly of bovine epidermal keratin filaments in vitro

1976 • 388 citations

Mutations in the Rod Domains of Keratins 1 and 10 in Epidermolytic Hyperkeratosis

1992 • 370 citations

The genetic basis of epidermolytic hyperkeratosis: A disorder of differentiation-specific epidermal keratin genes

1992 • 339 citations

Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments

1983 • 336 citations

Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin

1990 • 328 citations

Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins.

1991 • 305 citations

A leucine→proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis

1992 • 284 citations

Structure of the human desmoplakins. Implications for function in the desmosomal plaque.

1990 • 275 citations

Keratin Intermediate Filament Structure

1993 • 260 citations

The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments.

1986 • 259 citations

The coiled coil of in vitro assembled keratin filaments is a heterodimer of type I and II keratins: use of site-specific mutagenesis and recombinant protein expression.

1990 • 239 citations

The fibrillar substructure of keratin filaments unraveled.

1983 • 219 citations

The two-chain coiled-coil molecule of native epidermal keratin intermediate filaments is a type I-type II heterodimer.

1990 • 206 citations

A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases.

1991 • 202 citations

Glycine loops in proteins: their occurence in certain intermediate filament chains, loricrins and single-stranded RNA binding proteins

1991 • 194 citations

Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled coil.

1991 • 188 citations

Intermediate filament dynamics

1990 • 184 citations

Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits.

1985 • 183 citations

Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis.

1992 • 178 citations

Intermediate filament structure: 3. Analysis of sequence homologies

1988 • 178 citations

Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: members of a new gene family involved in organization of intermediate filaments

1992 • 169 citations

Steady state dynamics of intermediate filament networks.

1992 • 162 citations

Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins

1991 • 162 citations

The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

1993 • 160 citations

Pathway of incorporation of microinjected lamin A into the nuclear envelope.

1992 • 160 citations

Nuclear lamina and organization of nuclear architecture

1986 • 138 citations

The coiled-coil molecules of intermediate filaments consist of two parallel chains in exact axial register

1985 • 129 citations

Characterization of human cytokeratin 2, an Epidermal cytoskeletal protein synthesized late during differentiation

1992 • 129 citations

Dynamic aspects of intermediate filament networks in BHK-21 cells.

1989 • 125 citations

Profilaggrin is a Major Epidermal Calcium-Binding Protein

1993 • 123 citations

Intermediate filaments in alpha-keratins.

1986 • 114 citations

Molecular genetics of epidermolysis bullosa

1992 • 110 citations

Profilaggrin is a major epidermal calcium-binding protein.

1993 • 107 citations

Linkage of epidermolytic hyperkeratosis to the type II keratin gene cluster on chromosome 12q

1992 • 101 citations

The Mechanism of Interaction of Filaggrin with Intermediate Filaments

1993 • 100 citations

The conserved H1 domain of the type II keratin 1 chain plays an essential role in the alignment of nearest neighbor molecules in mouse and human keratin 1/keratin 10 intermediate filaments at the two- to four-molecule level of structure.

1993 • 99 citations

Keratin incorporation into intermediate filament networks is a rapid process.

1991 • 97 citations

Cytokeratin phosphorylation, cytokeratin filament severing and the solubilization of the maternal mRNA Vg1.

1991 • 92 citations

Epidermal keratin filaments assembled in vitro have masses-per-unit-length that scale according to average subunit mass: structural basis for homologous packing of subunits in intermediate filaments.

1983 • 84 citations

The Proteins of Hair and Other Hard α-Keratins

1990 • 80 citations

Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops.

1992 • 79 citations

Analysis of the mechanism of assembly of mouse keratin 1/keratin 10 intermediate filaments in vitro suggests that intermediate filaments are built from multiple oligomeric units rather than a unique tetrameric building block

1991 • 73 citations

The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences.

1988 • 73 citations

The dynamic phosphorylation of the human intermediate filament keratin 1 chain.

1988 • 72 citations

Genetic Skin Disorders of Keratin

1992 • 69 citations

Organization of coiled-coil molecules in native mouse keratin 1/keratin 10 intermediate filaments: Evidence for alternating rows of antiparallel in-register and antiparallel staggered molecules

1991 • 66 citations

Intermediate filament plasma membrane interactions

1991 • 65 citations

Intermediate filaments: not so tough after all

1992 • 65 citations

Solid-state NMR studies of the dynamics and structure of mouse keratin intermediate filaments

1988 • 65 citations

A synthetic peptide representing the consensus sequence motif at the carboxy-terminal end of the rod domain inhibits intermediate filament assembly and disassembles preformed filaments.

1992 • 61 citations

Reversible hyperphosphorylation and reorganization of vimentin intermediate filaments by okadaic acid in 9L rat brain tumor cells

1992 • 59 citations

Linkage of the Epidermolytic Hyperkeratosis Phenotype and the Region of the Type II Keratin Gene Cluster on Chromosome 12

1992 • 59 citations

The Two Size Alleles of Human Keratin 1 Are Due to a Deletion in the Glycine-Rich Carboxyl-Terminal V2 Subdomain

1992 • 45 citations

Cell cycle-dependent changes in the organization of an intermediate filament-associated protein: correlation with phosphorylation by p34cdc2.

1992 • 30 citations

The Three-Dimensional Structure of IF

1990 • 21 citations

Dynamic Aspects of Cytoskeletal and Karyoskeletal Intermediate Filament Systems during the Cell Cycle

1991 • 13 citations

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