Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic

1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive

1993 • 1,416 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

1991 • 429 citations

A potent cyclic hexapeptide analogue of somatostatin

1981 • 413 citations

SNAP family of NSF attachment proteins includes a brain-specific isoform

1993 • 277 citations

De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing .beta.-D-glucose as a novel scaffolding

1993 • 270 citations

A Kinetic Partitioning Model of Selective Binding of Nonnative Proteins by the Bacterial Chaperone SecB

1991 • 225 citations

Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research

1991 • 224 citations

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK ₁ ) Receptor Antagonist

1991 • 221 citations

Somatostatin and ACTH are peptides with partial antagonist-like selectivity for opiate receptors

1976 • 213 citations

Peptides: Chemistry, Structure and Biology (Proceedings of the 4th American Peptide Symposium)

1976 • 153 citations

The Receptors : a comprehensive treatise

1979 • 145 citations

Design and synthesis of somatostatin analogs with topographical properties that lead to highly potent and specific .mu. opioid receptor antagonists with greatly reduced binding at somatostatin receptors

1988 • 130 citations

Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptor.

1995 • 113 citations

Replication of transcriptionally active chromatin

1995 • 108 citations

Oestradiol, sexual receptivity and cytosol progestin receptors in rat hypothalamus

1981 • 100 citations

A new approach to receptor ligand design: synthesis and conformation of a new class of potent and highly selective μ opioid antagonists utilizing tetrahydroisoouinoline carroxylic acid

1988 • 92 citations

Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.

1994 • 90 citations

Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyrido[3,4-b]pyridine

1995 • 74 citations

Rationale for the synthesis and preliminary biological evaluation of highly active new antitumor nitrosoureido sugars

1989 • 65 citations

Tryptophan-Derived NK1 Antagonists: Conformationally Constrained Heterocyclic Bioisosteres of the Ester Linkage

1995 • 59 citations

Identification of L-Tryptophan Derivatives with Potent and Selective Antagonist Activity at the NK1 Receptor

1994 • 57 citations

Design, synthesis, and binding affinity of a nonpeptide mimic of somatostatin

1992 • 55 citations

3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists

1996 • 49 citations

Synthesis and antitumor activity of 5-azacytosine arabinoside

1979 • 47 citations

On the origins of the DNA sequence selectivity of mitomycin monoalkylation transformations

1992 • 47 citations

Preparation of exo-6-benzyl-exo-2-(m-hydroxyphenyl)-1-dimethylaminomethylbicyclo[2.2.2.]octane. A non-peptide mimic of enkephalins

1986 • 44 citations

Identification of a Series of 3-(Benzyloxy)-1-azabicyclo[2.2.2]octane Human NK1 Antagonists

1995 • 42 citations

Multiple peptide synthesis using a single support (MPS3)

1990 • 40 citations

Molecular characterization of a common binding site for small molecules within the transmembrane domain of G-protein coupled receptors

1995 • 37 citations

6agonist selectivity determinants in somatostatin receptor subtypes I and II.

1994 • 34 citations

Spiro-piperidine non-peptide neurokinin-1 receptor antagonists

1995 • 10 citations