Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Amino‐aromatic interactions in proteins

1986 • 752 citations

Weakly Polar Interactions In Proteins

1988 • 724 citations

Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

1991 • 429 citations

Hemoglobin as a receptor of drugs and peptides: x-ray studies of the stereochemistry of binding

1986 • 290 citations

Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor.

1992 • 242 citations

Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.

1991 • 237 citations

Amino–aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

1993 • 185 citations

Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.

1992 • 138 citations

Direct evidence that capsaicin-induced plasma protein extravasation is mediated through tachykinin NK1 receptors

1991 • 94 citations

Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation

1992 • 91 citations

Antiinflammatory and analgesic activity of a non-peptide substance P receptor antagonist

1992 • 74 citations

N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists

1993 • 73 citations

Quinuclidine-based NK-1 antagonists I: 3-benzyloxy-1-azabicyclo[2.2.2]octanes

1993 • 30 citations

Quinuclidine based NK-1 antagonists 2: determination of the absolute stereochemical requirements

1993 • 19 citations