CD40 signaling in vascular cells: A key role in atherosclerosis?

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture.

1994 • 1,125 citations

Immune Mechanisms in Atherosclerosis

2001 • 852 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

Immune mechanisms in atherosclerosis.

1989 • 827 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults.

1989 • 740 citations

Detection of activated T lymphocytes in the human atherosclerotic plaque.

1989 • 739 citations

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

1997 • 737 citations

Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions.

1991 • 669 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

1997 • 493 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.

1995 • 481 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.

1984 • 470 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Atherosclerosis and Coronary Artery Disease

1996 • 438 citations

Increased incidence of Chlamydiaspecies within the coronary arteries of patients with symptomatic atherosclerotic versus other forms of cardiovascular disease

1996 • 423 citations

Expression of functional CD40 by vascular endothelial cells.

1995 • 414 citations

Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65.

1992 • 397 citations

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.

1995 • 371 citations

Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.

1995 • 368 citations

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

1992 • 357 citations

Macrophages, Smooth Muscle Cells, and Tissue Factor in Unstable Angina

1996 • 357 citations

Regulation of Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells by T Lymphocytes

1997 • 342 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

HIGH LEVELS OF CYTOMEGALOVIRUS ANTIBODY IN PATIENTS REQUIRING VASCULAR SURGERY FOR ATHEROSCLEROSIS

1987 • 291 citations

Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals.

1995 • 280 citations

T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1.

1992 • 257 citations

Immune mechanisms in atherosclerosis.

1989 • 247 citations

Preliminary Communication

1964 • 234 citations

Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation

1995 • 230 citations

T lymphocytes in aortic and coronary intimas. Their potential role in atherogenesis.

1988 • 226 citations

Culture of quiescent arterial smooth muscle cells in a defined serum‐free medium

1983 • 220 citations

Functions of CD40 and Its Ligand, gp39 (CD40L)

2017 • 212 citations

Herpesviridae in the coronary arteries and aorta of young trauma victims.

1988 • 207 citations

Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction.

1996 • 197 citations

T Lymphocytes Induce Endothelial Cell Matrix Metalloproteinase Expression by a CD40L-Dependent Mechanism

1999 • 178 citations

Immunology of atherosclerosis: Cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens

1990 • 173 citations

A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes

1985 • 169 citations

Localization of T lymphocytes and macrophages in fibrous and complicated human atherosclerotic plaques

1988 • 152 citations

Identification of a human epithelial cell surface protein sharing an epitope with the C3d/epstein‐barr virus receptor molecule of B lymphocytes

1989 • 149 citations

Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA‐1

1995 • 132 citations

Functions of CD40 and Its Ligand, gp39 (CD40L)

1996 • 126 citations

Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin‐12 for interferon‐γ production

1996 • 126 citations

Ligation of CD40 Activates Interleukin 1β-converting Enzyme (Caspase-1) Activity in Vascular Smooth Muscle and Endothelial Cells and Promotes Elaboration of Active Interleukin 1β

1997 • 123 citations

Complement receptors and regulatory proteins in human atherosclerotic lesions.

1989 • 110 citations

CD40-CD40L interactions inatherosclerosis

1997 • 80 citations

Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.

1995 • 42 citations

Diversity of T-cell antigen receptor V beta gene utilization in advanced human atheroma.

1994 • 35 citations

Immunology of atherosclerosis: the promise of mouse models.

1996 • 30 citations

Diversity of T-cell antigen receptor V beta gene utilization in advanced human atheroma.

1994 • 17 citations