Intact Vinculin Protein Is Required for Control of Cell Shape, Cell Mechanics, and rac-Dependent Lamellipodia Formation

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

From Molecules to Cells: Imaging Soft Samples with the Atomic Force Microscope

1992 • 886 citations

Measuring the viscoelastic properties of human platelets with the atomic force microscope

1996 • 815 citations

Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus

1981 • 591 citations

Relative Microelastic Mapping of Living Cells by Atomic Force Microscopy

1998 • 538 citations

Vinculin knockout results in heart and brain defects during embryonic development

1998 • 511 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Cell migration: regulation of force on extracellular-matrix-integrin complexes

1998 • 443 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

F-actin binding site masked by the intramolecular association of vinculin head and tail domains

1995 • 371 citations

Vinculin Promotes Cell Spreading by Mechanically Coupling Integrins to the Cytoskeleton

1997 • 267 citations

High Resolution Detection of Mechanical Forces Exerted by Locomoting Fibroblasts on the Substrate

1999 • 254 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Fibronectin and Integrins in Cell Adhesion, Signaling, and Morphogenesis

1998 • 235 citations

An intramolecular association between the head and tail domains of vinculin modulates talin binding.

1994 • 212 citations

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.

1995 • 203 citations

[1] Purification of recombinant Rho/Rac/G25K from Escherichia coli

1995 • 190 citations

Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.

1987 • 163 citations

Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin

1998 • 131 citations

Translocation of pp60c-src to the cytoskeleton during platelet aggregation.

1992 • 120 citations

Differences in Elasticity of Vinculin-Deficient F9 Cells Measured by Magnetometry and Atomic Force Microscopy

1998 • 117 citations

Actin Activates a Cryptic Dimerization Potential of the Vinculin Tail Domain

2000 • 81 citations

Motility of Vinculin-Deficient F9 Embryonic Carcinoma Cells Analyzed by Video, Laser Confocal, and Reflection Interference Contrast Microscopy

1995 • 55 citations

Expression of chicken vinculin complements the adhesion-defective phenotype of a mutant mouse F9 embryonal carcinoma cell.

1993 • 46 citations

Differences in F9 and 5.51 cell elasticity determined by cell poking and atomic force microscopy

1998 • 38 citations

[34] Microinjection of Rho and Rac into quiescent Swiss 3T3 cells

1995 • 21 citations

Subtypes of protein kinase C in isolated nerve growth cones: Only type II is associated with the membrane skeleton from growth cones

1991 • 17 citations

<title>Scanning force microscopy of cells and membrane proteins</title>

1992 • 10 citations

Mammalian Cell Microinjection Assay to Study the Function of Rat and Rho

2003 • 8 citations