DNA methylation analysis at distal and proximal promoter regions of the oestrogen receptor gene in breast cancers

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

1994 • 481 citations

Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

1995 • 301 citations

Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer.

1995 • 297 citations

Association between CpG island methylation and microsatellite instability in colorectal cancer.

1997 • 295 citations

Estrogen Receptor Gene Analysis in Estrogen Receptor-Positive and Receptor-Negative Primary Breast Cancer

1995 • 271 citations

MINIREVIEW: Estrogen Receptor Variants in Clinical Breast Cancer

1991 • 262 citations

Mapping of ER gene CpG island methylation-specific polymerase chain reaction.

1998 • 209 citations

Estrogen receptor mutations in tamoxifen-resistant breast cancer.

1994 • 192 citations

Antiestrogens: Mechanisms of action and resistance in breast cancer

1997 • 183 citations

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.

1995 • 147 citations

Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells

1997 • 146 citations

Estrogen target tissue determines alternative promoter utilization of the human estrogen receptor gene in osteoblasts and tumor cell lines.

1995 • 104 citations

Sequence variants of the estrogen receptor (ER) gene found in breast cancer patients with ER negative and progesterone receptor positive tumors

1996 • 60 citations

Two promoters in expression of estrogen receptor messenger RNA in human breast cancer

1997 • 58 citations

Oestrogen receptor gene structure and function in breast cancer

1992 • 50 citations

Estrogen receptor gene methylation in human breast tumors.

1990 • 46 citations

Loss of heterozygosity of the oestrogen receptor gene in breast cancer

1995 • 42 citations

Methylation of CpG island is not a ubiquitous mechanism for the loss of oestrogen receptor in breast cancer cells

1998 • 19 citations