Oestrogen receptor gene structure and function in breast cancer

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Cloning of the human estrogen receptor cDNA.

1985 • 720 citations

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

1987 • 413 citations

Variant human breast tumor estrogen receptor with constitutive transcriptional activity.

1991 • 397 citations

DNA Methylation and Cancer

2000 • 266 citations

DNA methylation. The effect of minor bases on DNA-protein interactions

1990 • 181 citations

Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism.

1989 • 145 citations

Human Progesterone Receptor Complexed with the Antagonist RU 486 Binds to Hormone Response Elements in a Structurally Altered Form

1989 • 138 citations

Human estrogen receptor forms multiple protein-DNA complexes.

1990 • 126 citations

T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance.

1990 • 121 citations

Variant Estrogen Receptor mRNA Species Detected in Human Breast Cancer Biopsy Samples

1989 • 111 citations

Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer

1990 • 111 citations

DNA Methylation and Cancer

1985 • 104 citations

Cellular and molecular events in loss of estrogen sensitivity in ZR-75-1 and T-47-D human breast cancer cells.

1990 • 82 citations

Genomic DNA analysis of the estrogen receptor gene in breast cancer

1989 • 69 citations

Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells.

1988 • 62 citations

Progression to steroid autonomy in S115 mouse mammary tumor cells: role of DNA methylation.

1984 • 54 citations

Estrogen receptor gene methylation in human breast tumors.

1990 • 46 citations

Different methylation of oestrogen receptor DNA in human breast carcinomas with and without oestrogen receptor

1990 • 44 citations

Estrogen receptor gene amplification is found in some estrogen receptor-positive human breast tumors

1990 • 36 citations

Human estrogen receptor (ESR) gene locus: PssI dimorphism

1988 • 13 citations