Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

Wnt signaling and cancer

2000 • 3,215 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

2001 • 1,684 citations

The renaissance of GSK3

2001 • 1,459 citations

The multifaceted roles of glycogen synthase kinase 3β in cellular signaling

2001 • 1,408 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

Molecular cloning and expression of glycogen synthase kinase-3/factor A.

1990 • 1,329 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

GSK3 takes centre stage more than 20 years after its discovery

2001 • 1,298 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

GSK3 takes centre stage more than 20 years after its discovery

2001 • 939 citations

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

2000 • 867 citations

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1999 • 784 citations

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

2001 • 685 citations

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

2001 • 679 citations

Crystal Structure of Glycogen Synthase Kinase 3β

2001 • 636 citations

The role of protein phosphorylation in human health and disease.

2001 • 596 citations

The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 485 citations

Lithium Inhibits Glycogen Synthase Kinase-3 by Competition for Magnesium

2001 • 482 citations

Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

1997 • 459 citations

Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine

1992 • 454 citations

The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3

2000 • 434 citations

First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease

2002 • 430 citations

Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent

2000 • 419 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Glucose Sensing in Pancreatic β-Cells

2001 • 396 citations

Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy

2000 • 390 citations

Structure of GSK3beta reveals a primed phosphorylation mechanism.

2001 • 368 citations

Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β

2000 • 361 citations

Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25

2000 • 361 citations

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

2001 • 361 citations

Spatial learning deficit in transgenic mice that conditionally over‐express GSK‐3β in the brain but do not form tau filaments

2002 • 360 citations

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

2000 • 344 citations

The Molecular Bases of Alzheimer's Disease and Other Neurodegenerative Disorders

2001 • 337 citations

Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons

1997 • 315 citations

Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

1999 • 314 citations

Judging a Protein by More Than Its Name: GSK-3

2001 • 281 citations

Lithium protects cultured neurons against β‐amyloid‐induced neurodegeneration

1999 • 269 citations

Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

1999 • 219 citations

GSK3, a master switch regulating cell-fate specification and tumorigenesis

2000 • 219 citations

Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

2001 • 215 citations

The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation

2001 • 194 citations

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3? and cdk5 are key participants

2000 • 173 citations

Current Therapies and Emerging Targets for the Treatment of Diabetes

2001 • 167 citations

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

2001 • 156 citations

Lithium therapy and signal transduction

2000 • 155 citations

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations

1999 • 154 citations

Glycogen Synthase Kinase 3β Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1

2000 • 154 citations

Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers

2001 • 141 citations

The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31‐8220) are potent inhibitors of glycogen synthase kinase‐3 activity

1999 • 140 citations

Anti-mitotic properties of indirubin-3′-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest

2001 • 134 citations

A Structure-Based Library Approach to Kinase Inhibitors

1996 • 125 citations

Neurofibrillary tangles and tau phosphorylation

2001 • 123 citations

Low GSK-3 activity in frontal cortex of schizophrenic patients

2001 • 123 citations

Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase

2001 • 119 citations

Identification of the Axin and Frat Binding Region of Glycogen Synthase Kinase-3

2002 • 113 citations

Expression analysis of glycogen synthase kinase‐3 in human tissues

1999 • 112 citations

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K⁺deprivation in cerebellar granule cells

2001 • 99 citations

Integrin-linked kinase (ILK): a “hot” therapeutic target

2000 • 98 citations

Glycogen Synthase Kinase-3β Regulates Presenilin 1 C-terminal Fragment Levels

2001 • 98 citations

GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity

2001 • 87 citations

Selective small‐molecule inhibitors of glycogen synthase kinase‐3 activity protect primary neurones from death

2001 • 84 citations

Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3β inhibition and in neurons

2000 • 83 citations

N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors

2000 • 77 citations

Therapeutic Strategies in Alzheimer’s Disease: Ml Muscarinic Agonists

2000 • 74 citations

Molecular Cloning and Characterization of the Human Glycogen Synthase Kinase-3β Promoter

1999 • 68 citations

M1 Muscarinic Agonists as Potential Disease‐Modifying Agents in Alzheimer's Disease: Rationale and Perspectives

2000 • 62 citations

Phosphorylation of tau by glycogen synthase kinase 3β in intact mammalian cells influences the stability of microtubules

2001 • 60 citations

Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 β gene and promoter in late onset Alzheimer's disease

2001 • 60 citations

Missing Links in GSK3 Regulation

2001 • 59 citations

The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB.

1997 • 57 citations

Lithium-related genetics of bipolar disorder

2001 • 46 citations

Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimers Disease

2002 • 40 citations

Inhibition of tau phosphorylation: a new therapeutic strategy for the treatment of Alzheimer’s disease and other neurodegenerative disorders

2000 • 39 citations

Synthesis and Potential Muscarinic Receptor Binding and Antioxidant Properties of 3-(Thiadiazolyl)pyridine 1-Oxide Compounds

1999 • 38 citations

Inhibition of voltage‐dependent sodium channels by Ro 31‐8220, a ‘specific’ protein kinase C inhibitor

2000 • 34 citations

Glycogen synthase kinase 3 phosphorylation of different residues in the presence of different factors: Analysis on tau protein

1996 • 33 citations

Different expression of glycogen synthase kinase-3βbetween young and old rat brains after transient middle cerebral artery occlusion

2001 • 33 citations

Synthese von 7,12‐Dihydro‐indolo[3,2‐d][1]benzazepin‐6‐(5H)‐onen und 6,11‐Dihydro‐thieno‐[3′,2′:2,3]azepino[4,5‐b]indol‐5(4H)‐on

1992 • 32 citations

The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer

2001 • 23 citations

Reactions of N‐Alkyl‐ and N‐Aryl‐S‐chloroisothiocarbamoyl Chlorides with Isocyanates; Synthesis of 1,2,4‐Thiadiazolidine‐3,5‐diones

1966 • 16 citations

Arylimino-1,2,4-thiadiazolidinones: A new family of potassium channel openers

1997 • 16 citations

Experimentally Induced Benignancy of Neoplasm. V. The Influence of Hormones on the Host's Resistance to Implanted Neoplasm

1941 • 10 citations

Traditional and Modern Medicine

2016 • 6 citations

Glycogen synthase kinase-3beta as a target for anti-apoptotic signals

2001 • 1 citations