Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo

Theory and Practice of Histological Techniques

1990 • 6,957 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

2001 • 1,469 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 • 1,311 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease

2001 • 903 citations

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

2001 • 889 citations

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

2001 • 865 citations

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

1993 • 759 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

A brain-specific activator of cyclin-dependent kinase 5

1994 • 575 citations

Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

2002 • 474 citations

Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5

1993 • 470 citations

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1997 • 438 citations

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

1993 • 379 citations

Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain

1997 • 344 citations

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

2000 • 336 citations

Phosphorylation of Tau at Both Thr 231 and Ser 262 Is Required for Maximal Inhibition of Its Binding to Microtubules

1998 • 321 citations

Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice

2000 • 313 citations

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

1993 • 289 citations

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

2000 • 282 citations

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II

1996 • 246 citations

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M

1998 • 231 citations

Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases

2002 • 224 citations

Theory and Practice of Histological Techniques Edited by J.D. Bancroft & A. Stevens, Churchill Livingstone, Edinburgh, 740 pages, £55.00

1990 • 214 citations

Deregulation of cdk5, Hyperphosphorylation, and Cytoskeletal Pathology in the Niemann–Pick Type C Murine Model

2002 • 182 citations

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK‐3β

2002 • 181 citations

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

2002 • 180 citations

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3? and cdk5 are key participants

2000 • 173 citations

Silver Impregnation of Alzheimer's Neurofibrillary Changes Counterstained for Basophilic Material and Lipofuscin Pigment

1988 • 166 citations

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain

1999 • 165 citations

Structure of tau protein and assembly into paired helical filaments

2000 • 161 citations

Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.

1997 • 157 citations

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease

1997 • 150 citations

Truncation of CDK5 Activator p35 Induces Intensive Phosphorylation of Ser202/Thr205 of Human Tau

2002 • 140 citations

Tau protein I is essential for amyloid β-protein iduced neurotoxicity

1993 • 125 citations

A Cdk5–p35 Stable Complex Is Involved in the β-Amyloid-Induced Deregulation of Cdk5 Activity in Hippocampal Neurons

2001 • 125 citations

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25‐transgenic mice

2002 • 99 citations

Aβ amyloidosis induces the initial stage of tau accumulation in APPSw mice

2001 • 95 citations

p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitro

2002 • 94 citations

m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains

1998 • 89 citations

Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites

1995 • 85 citations

Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells

1998 • 85 citations

Role of GSK‐3β in Alzheimer's disease pathology

2002 • 76 citations

A Role for Cyclin-Dependent Kinase(s) in the Modulation of Fast Anterograde Axonal Transport: Effects Defined by Olomoucine and the APC Tumor Suppressor Protein

1998 • 73 citations

Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

2001 • 71 citations

Direct interaction of soluble human recombinant tau protein with Aβ 1–42 results in tau aggregation and hyperphosphorylation by tau protein kinase II

2002 • 68 citations

Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice

2001 • 43 citations

Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by munc-18

1996 • 30 citations