Experimental studies of folding kinetics and structural dynamics of small proteins

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Stability of Proteins Small Globular Proteins

1979 • 2,139 citations

The interaction of a naphthalene dye with apomyoglobin and apohemoglobin

1965 • 1,486 citations

Structure and stability of biological macromolecules

1969 • 1,313 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding

1982 • 1,041 citations

Experimental studies of protein folding and unfolding

1979 • 535 citations

A Partial Determination by X-ray Methods, and its Correlation with Chemical Data

1961 • 486 citations

Primary structure effects on peptide group hydrogen exchange

1972 • 463 citations

Co-operative non-enzymatic base recognition III. Kinetics of the helix—coil transition of the oligoribouridylic · oligoriboadenylic acid system and of oligoriboadenylic acid alone at acidic pH

1971 • 433 citations

Conformational energy estimates for statistically coiling polypeptide chains

1967 • 349 citations

Amide proton exchange and surface conformation of the basic pancreatic trypsin inhibitor in solution

1982 • 332 citations

Physicochemical Aspects of Protein Denaturation

1978 • 308 citations

Motions in Proteins

1979 • 281 citations

Thermodynamics of the denaturation of lysozyme in alcohol-water mixtures

1979 • 204 citations

The Equilibrium Unfolding Parameters of Horse and Sperm Whale Myoglobin

1973 • 197 citations

Relative Conformations of Sperm Whale Metmyoglobin and Apomyoglobin in Solution

1965 • 190 citations

Protein dynamics investigated by the neutron diffraction–hydrogen exchange technique

1982 • 180 citations

Conformation states of concanavalin A: Kinetics of transitions induced by interaction with Mn²⁺ and Ca²⁺

1977 • 176 citations

Kinetics of unfolding and refolding of proteins

1973 • 173 citations

A folding model of α-lactalbumin deduced from the three-state denaturation mechanism

1977 • 173 citations

A quantitative treatment of the kinetics of the folding transition of ribonuclease A

1976 • 167 citations

An experimental procedure for increasing the structural resolution of chemical hydrogen-exchange measurements on proteins: Application to ribonuclease S peptide

1979 • 164 citations

Intermediates in the refolding of reduced ribonuclease A

1979 • 159 citations

Effect of proline residues on protein folding

1981 • 155 citations

Detection of an early intermediate in the folding of ribonuclease A by protection of amide protons against exchange

1979 • 154 citations

Dynamics of Proteins

1982 • 148 citations

Test of the extended two-state model for the kinetic intermediates observed in the folding transition of ribonuclease A

1978 • 137 citations

THE LIMITED DIGESTION OF RIBONUCLEASE WITH PEPSIN

1956 • 136 citations

A sequential model of nucleation-dependent protein folding: Kinetic studies of ribonuclease A

1972 • 132 citations

Hydrogen isotope exchange kinetics of single protons in bovine pancreatic trypsin inhibitor

1980 • 126 citations

Kinetic study of protein unfolding and refolding using urea gradient electrophoresis

1980 • 121 citations

Structural interpretation of the amide proton exchange in the basic pancreatic trypsin inhibitor and related proteins

1979 • 120 citations

Kinetics of unfolding and refolding of proteins

1973 • 119 citations

A Native‐Like Intermediate on the Ribonuclease A Folding Pathway

1981 • 118 citations

Anion binding and pH-dependent electrostatic effects in ribonuclease

1982 • 117 citations

Mechanisms of protein and polypeptide helix initiation

1975 • 107 citations

Spectral studies on the denaturation of myoglobin

1968 • 98 citations

The Tryptophan Microenvironments in Apomyoglobin

1970 • 98 citations

Formation of Randomly Paired Disulfide Bonds in Des-(121–124)-ribonuclease after Reduction and Reoxidation

1970 • 93 citations

Individual breathing reactions measured in hemoglobin by hydrogen exchange methods

1980 • 92 citations

Spectral evidence for a rapidly formed structural intermediate in the refolding kinetics of hen egg-white lysozyme

1981 • 87 citations

Unfolding and refolding of the reduced constant fragment of the immunoglobulin light chain

1982 • 86 citations

Structural intermediates trapped during the folding of ribonuclease A by amide proton exchange

1980 • 86 citations

Thermodynamics of protein cross-links

1978 • 85 citations

The Structural Roles of Amino Acid Residues Near the Carboxyl Terminus of Bovine Pancreatic Ribonuclease A

1970 • 84 citations

Volume occupation, environment, and accessibility in proteins. Environment and molecular area of RNase-S

1978 • 77 citations

Concentration-dependent hydrogen exchange kinetics of 3H-labeled S-peptide in ribonuclease S

1976 • 74 citations

The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration

1979 • 71 citations

A Native‐Like Intermediate on the Ribonuclease A Folding Pathway

1981 • 69 citations

Secondary structure in ribonuclease

1982 • 67 citations

Conformation and conformational stability of ribonuclease A and its peptic derivative, des-(121-124)-ribonuclease

1972 • 67 citations

Tryptophanyl fluorescence heterogeneity of apomyoglobins. Correlation with the presence of two distinct structural domains

1981 • 66 citations

Identification and characterization of the direct folding process of hen egg-white lysozyme

1982 • 65 citations

Hydrogen exchange from identified regions of the S-protein component of ribonuclease as a function of temperature, pH, and the binding of S-peptide

1981 • 59 citations

Kinetics of conformation change of sperm-whale myoglobin. I. Folding and unfolding of metmyoglobin following pH jump

1972 • 59 citations

The nature of the slow metal ion-dependent conformational transition in bovine prothrombin

1979 • 58 citations

Kinetic analysis of the reversible folding reactions of small proteins: Application to the folding of lysozyme and cytochrome c

1977 • 56 citations

Characterization of the slow steps in the folding of the .alpha. subunit of tryptophan synthase

1981 • 54 citations

Exchange behavior of the H-bonded amide protons in the 3 to 13 helix of ribonuclease S

1983 • 49 citations

Reaction of N-acetylglucosamine oligosaccharides with lysozyme. Temperature, pH, and solvent deuterium isotope effects; equilbrium, steady state, and pre-steady state measurements*

1975 • 49 citations

Mechanism of dissociation of S-peptide from ribonuclease S

1977 • 48 citations

The role of proline residues in the folding kinetics of the bovine pancreatic trypsin inhibitor derivative RCAM(14–38)

1981 • 48 citations

Proline peptide isomerization and the reactivation of denatured enzymes

1979 • 47 citations

Kinetics of thermal unfolding of lysozyme

1973 • 42 citations

Temperature‐dependence of the kinetics of folding of chymotrypsinogen A

1976 • 42 citations

Kinetic study of isomerization of ferricytochrome c at alkaline pH

1976 • 38 citations

Polynucleotides. IX. Temperature dependence of kinetics of complex formation in equimolar mixtures of polyriboadenylate and polyribouridylate

1968 • 36 citations

Stopped-flow fluorescence studies on saccharide binding to lysozyme

1975 • 36 citations

Role of the Interaction between Ionizable Groups in the Folding of Bovine α-Lactalbumin1

1981 • 34 citations

Strategy for trapping intermediates in the folding of ribonuclease and for using ¹H‐NMR to determine their structures

1983 • 27 citations

Studies of the conformation of apomyoglobin in aqueous solutions and denaturing organic solvents

1975 • 27 citations

The effect of evolution on homologous proteins: a comparison between the chromophore microenvironments of Italian water buffalo (Bos bubalus, L.) and sperm whale apomyoglobin.

1978 • 25 citations

Cooperative Conformational Changes in Globular Proteins

1972 • 25 citations

Simple sequential model for the kinetics of conformational transitions of oligomeric helices and proteins

1972 • 24 citations

Nature and locations of the most slowly exchanging peptide NH protons in residues 1 to 19 of ribonuclease S

1983 • 23 citations

Secondary structure in ribonuclease

1982 • 22 citations

Kinetics of conformation change of sperm-whale myoglobin. III. Folding and unfolding of apomyoglobin and the suggested overall mechanism

1972 • 20 citations

The inactivation of ribonuclease by restricted pepsin digestion

1955 • 19 citations

Fast kinetic studies with chiroptical techniques: Stopped flow circular dichroism and related methods

1981 • 18 citations

An early intermediate in the folding of ribonuclease A is protected against cleavage by pepsin

1984 • 14 citations

Kinetic study of myoglobin. Effect of external ligands on acidic denaturation

1982 • 12 citations

Direct observation of peptide exchange by stable isotope enrichment.

1980 • 12 citations

Kinetic study on the unfolding of apomyoglobin, detected by fluorescence- and circular dichroism-stopped-flow method

1980 • 11 citations

A kinetic study of the unfolding of myoglobin at low pH, monitored by absorbance and circular-dichroism stopped-flow

1982 • 9 citations