BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles

Molecular portraits of human breast tumours

2000 • 15,445 citations

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Hallmarks of 'BRCAness' in sporadic cancers

2004 • 1,586 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

2000 • 1,182 citations

The Pathology of Familial Breast Cancer: Predictive Value of Immunohistochemical Markers Estrogen Receptor, Progesterone Receptor, HER-2, and p53 in Patients With Mutations in BRCA1 and BRCA2

2002 • 809 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

2000 • 565 citations

Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors

2003 • 541 citations

BRCA1 is a component of the RNA polymerase II holoenzyme

1997 • 450 citations

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

2001 • 445 citations

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

1999 • 421 citations

Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA

1997 • 383 citations

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

1999 • 353 citations

Tumour biological features of BRCA1-induced breast and ovarian cancer

1997 • 346 citations

Aberrant Subcellular Localization of BRCA1 in Breast Cancer

1995 • 310 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 258 citations

Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

1998 • 245 citations

Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues

1980 • 243 citations

A SAGE (serial analysis of gene expression) view of breast tumor progression.

2001 • 242 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 231 citations

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

2000 • 220 citations

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

2001 • 212 citations

Loss of Heterozygosity and Its Correlation with Expression Profiles in Subclasses of Invasive Breast Cancers

2004 • 191 citations

Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells.

1996 • 146 citations

BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.

1996 • 143 citations

Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region

1998 • 135 citations

Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases.

1999 • 117 citations

Gene-Expression Profiles in Hereditary Breast Cancer

2001 • 100 citations

Haplo-insufficiency of BRCA1 in sporadic breast cancer.

2003 • 78 citations

The usefulness of antibodies to the BRCA1 protein in detecting the mutated BRCA1 gene. An immunohistochemical study

2001 • 55 citations

Quantification of BRCA1 protein in sporadic breast carcinoma with or without loss of heterozygosity of theBRCA1 gene

1999 • 54 citations

Preferential allelic expression can lead to reduced expression ofBRCA1 in sporadic breast cancers

1998 • 52 citations

BRCA1 Expression Status in Relation to DNA Methylation of the BRCA1 Promoter Region in Sporadic Breast Cancers

2000 • 51 citations

Promoter Hypermethylation and Post-transcriptional Mechanisms for Reduced BRCA1 Immunoreactivity in Sporadic Human Breast Cancers

2002 • 50 citations

High throughput fluorescence-based conformation-sensitive gel electrophoresis (F-CSGE) identifies six unique BRCA2 mutations and an overall low incidence of BRCA2 mutations in high-risk BRCA1-negative breast cancer families

1998 • 50 citations

Use of a DNA toolbox for the characterization of mutation scanning methods. I: Construction of the toolbox and evaluation of heteroduplex analysis

1999 • 45 citations

Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.

2003 • 28 citations

Testing for Hereditary Breast and Ovarian Cancer in the Southeastern United States

2000 • 20 citations