Preferential allelic expression can lead to reduced expression ofBRCA1 in sporadic breast cancers

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome

1992 • 414 citations

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1994 • 389 citations

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

1995 • 377 citations

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

1994 • 334 citations

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening

1995 • 329 citations

Identification and preliminary characterization of a protein motif related to the zinc finger.

1993 • 327 citations

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

1995 • 324 citations

Aberrant Subcellular Localization of BRCA1 in Breast Cancer

1995 • 310 citations

A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene

1995 • 243 citations

An improved strategy and a useful housekeeping gene for RNA analysis from formalin-fixed, paraffin-embedded tissues by PCR.

1993 • 203 citations

Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors.

1993 • 192 citations

BRCA1 is secreted and exhibits properties of a granin

1996 • 184 citations

Evidence for involvement of BRCA1 in sporadic breast carcinomas.

1994 • 71 citations

Allelic deletions at chromosome 11q22-q23.1 and 11q25-qterm are frequent in sporadic breast but not colorectal cancers

1997 • 54 citations

Refined localization of the asparagine synthetase gene (ASNS) to chromosome 7, region q21.3, and characterization of the somatic cell hybrid line 4AF/106/K015

1994 • 28 citations