Integration of the proteasome inhibitor PS-341 (Velcade) into the therapeutic approach to lung cancer

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Phase I Trial of the Proteasome Inhibitor PS-341 in Patients With Refractory Hematologic Malignancies

2002 • 771 citations

Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

2001 • 544 citations

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

2001 • 481 citations

The proteasome inhibitor PS-341 in cancer therapy.

1999 • 475 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies.

2002 • 446 citations

Bax degradation by the ubiquitin/proteasome-dependent pathway: Involvement in tumor survival and progression

2000 • 439 citations

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.

1997 • 428 citations

Endoproteolytic Activity of the Proteasome

2003 • 425 citations

Development of the Proteasome Inhibitor PS-341

2002 • 364 citations

Roles of ubiquitin-mediated proteolysis in cell cycle control

1997 • 348 citations

Enhancement of radiosensitivity by proteasome inhibition: Implications for a role of NF-κB

2001 • 323 citations

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

2001 • 316 citations

Proteasome Inhibition Measurements: Clinical Application

2000 • 308 citations

Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability

1997 • 305 citations

Proteasome Inhibition: a New Strategy in Cancer Treatment

2000 • 252 citations

Proteasome-Dependent Regulation of p21WAF1/CIP1Expression

1996 • 223 citations

Chemosensitization of Pancreatic Cancer by Inhibition of the 26S Proteasome

2001 • 215 citations

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

2000 • 212 citations

Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341.

2000 • 205 citations

P53: An ubiquitous target of anticancer drugs

2001 • 146 citations

Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras.

1999 • 123 citations

Gemcitabine-Induced Programmed Cell Death (Apoptosis) of Human Pancreatic Carcinoma Is Determined by Bcl-2 Content

1999 • 122 citations

Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53

1998 • 119 citations

Inhibition of NF-κB sensitizes non–small cell lung cancer cells to chemotherapy-induced apoptosis

2000 • 109 citations

Expression of bcl-2 — protein in small cell lung cancer

1996 • 103 citations

Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer

1999 • 95 citations

Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance

1996 • 89 citations

Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors.

2000 • 86 citations

Molecular Pathways That Modify Tumor Radiation Response

2001 • 72 citations

High cyclin E and low p27/Kip1 expressions are potentially poor prognostic factors in lung adenocarcinoma patients

2001 • 56 citations

NF-κB Activation Is Related to the Resistance of Lung Cancer Cells to TNF-α-Induced Apoptosis

2000 • 53 citations

Rel/NF-kappaB represses bcl-2 transcription in pro-B lymphocytes.

1999 • 36 citations

Molecular–clinical correlative studies in non-small cell lung cancer: application of a three-tiered approach

2001 • 24 citations

Inhibition of 20S proteasome results in serum IL-6 and PSA decline in patients (pts) with androgen-independent prostate cancer (AIPCa) treated with the proteasome inhibitor PS-341

2001 • 19 citations

Aberrant Expression of pRb, p16, p14ARF, MDM2, p21 and p53 in Squamous Cell Carcinomas of Lung

2001 • 17 citations

Cell cycle control and cancer: lessons from lung cancer.

1996 • 9 citations

Proteasome inhibitor PS-341 and docetaxel: sequence of administration may be crucial

2001 • 4 citations