Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Manual for Staging of Cancer

1992 • 2,367 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Cancer statistics, 1994

1994 • 1,345 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

1996 • 596 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

1994 • 461 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

1995 • 317 citations

Immunocytochemical markers in stage I lung cancer: relevance to prognosis.

1997 • 313 citations

A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression.

1995 • 300 citations

Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors.

1996 • 273 citations

Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer

1996 • 217 citations

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

1996 • 207 citations

Diminished Cell Proliferation Associated with the Death-protective Activity of Bcl-2

1996 • 202 citations

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

1995 • 201 citations

Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer.

1997 • 169 citations

Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor.

1995 • 160 citations

Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma

1996 • 154 citations

What is an apoptotic index measuring? A commentary

1996 • 145 citations

Immunohistochemical analysis of Bcl-2 family proteins in adenocarcinomas of the stomach.

1996 • 130 citations

Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

1995 • 115 citations

Immunohistochemical study of p53 in human lung carcinomas.

1993 • 103 citations

Prognostic significance of p53 andras p21 expression in nonsmall cell lung cancer

1995 • 81 citations

Frequent expression of the cell death-inducing gene Bax in Reed- Sternberg cells of Hodgkin's disease

1996 • 58 citations

Apoptosis in operated small cell lung carcinoma is inversely related to tumour necrosis and p53 immunoreactivity

1997 • 50 citations

Similarity of apoptosis induction by 2-chlorodeoxyadenosine and cisplatin in human mononuclear blood cells

1997 • 19 citations

p53 gene aberrations in non-small-cell lung carcinomas from a smoking population

1997 • 16 citations