The promise of retinoids to fight against cancer

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid

1999 • 1,843 citations

ABC of breast diseases: Breast cancer---epidemiology, risk factors, and genetics

2000 • 1,564 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

The retinoids—Biology, chemistry and medicine

1996 • 1,192 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

1999 • 1,051 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

The Retinoids-Biology, Chemistry and Medicine

1994 • 987 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

2000 • 731 citations

Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

1996 • 659 citations

Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 • 651 citations

Prevention of Skin Cancer in Xeroderma Pigmentosum with the Use of Oral Isotretinoin

1988 • 578 citations

The transcriptional role of PML and the nuclear body

2000 • 574 citations

Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

1998 • 571 citations

Role of SUMO-1–modified PML in nuclear body formation

2000 • 555 citations

Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats

1997 • 532 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

2000 • 502 citations

Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as2O3-Induced Pml or Pml/Retinoic Acid Receptor α Degradation

2001 • 477 citations

The function of PML in p53-dependent apoptosis

2000 • 464 citations

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

2000 • 459 citations

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development

1997 • 428 citations

Predicting cancer development in oral leukoplakia: ten years of translational research.

2000 • 426 citations

Molecular mechanisms of retinoid actions in skin

1996 • 418 citations

Crystal Structure of a Heterodimeric Complex of RAR and RXR Ligand-Binding Domains

2000 • 394 citations

Transcriptional cross-talk, the second mode of steroid hormone receptor action

1998 • 390 citations

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.

1994 • 377 citations

Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice

1998 • 357 citations

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL

2001 • 344 citations

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

1997 • 337 citations

13-cis-Retinoic Acid Plus Interferon -2a: Highly Active Systemic Theraphy for Squamous Cell Carcinoma of the Cervix

1992 • 321 citations

Randomized Phase III Intergroup Trial of Isotretinoin to Prevent Second Primary Tumors in Stage I Non-Small-Cell Lung Cancer

2001 • 318 citations

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation

1994 • 318 citations

Abnormal spermatogenesis in RXR beta mutant mice.

1996 • 311 citations

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.

1993 • 307 citations

Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis

2000 • 307 citations

v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.

1990 • 300 citations

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

2002 • 300 citations

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

1998 • 292 citations

ABC of breast diseases

2012 • 289 citations

Oligomerization of RAR and AML1 Transcription Factors as a Novel Mechanism of Oncogenic Activation

2000 • 286 citations

Mediator complexes and transcription

2001 • 278 citations

Enhancement of Regression of Cervical Intraepithelial Neoplasia II (Moderate Dysplasia) With Topically Applied All- trans -Retinoic Acid: a Randomized Trial

1994 • 273 citations

Phase III Trial of Interferon Alfa-2a With or Without 13-cis-Retinoic Acid for Patients With Advanced Renal Cell Carcinoma

2000 • 271 citations

Methylation and Silencing of the Retinoic Acid Receptor- 2 Gene in Breast Cancer

2000 • 260 citations

RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.

1995 • 257 citations

The TRAP/SMCC/Mediator complex and thyroid hormone receptor function

2001 • 250 citations

Activation of Retinoid X Receptors Induces Apoptosis in HL-60 Cell Lines

1995 • 247 citations

Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia.

2001 • 241 citations

Acquisition of Oncogenic Potential by RAR Chimeras in Acute Promyelocytic Leukemia through Formation of Homodimers

2000 • 229 citations

Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver

2000 • 226 citations

Prevention of Second Primary Tumors With Isotretinoin in Patients With Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up

1994 • 208 citations

Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

2001 • 204 citations

Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand.

1996 • 202 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

Initial clinical trial of a selective retinoid X receptor ligand, LGD1069.

1997 • 189 citations

Intracellular Signaling by 14-hydroxy-4,14- Retro -Retinol

1991 • 184 citations

Effect of polar organic compounds on leukemic cells: Butyrate-induced partial remission of acute myelogenous leukemia in a child

1983 • 164 citations

Role of PML and PML-RARα in Mad-Mediated Transcriptional Repression

2001 • 143 citations

Retinoic Acid Redifferentiation Therapy for Thyroid Cancer

2000 • 139 citations

All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia

2001 • 139 citations

Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: the trail to non-toxic cancer therapeutics (review).

1999 • 137 citations

A clinical evaluation

1961 • 137 citations

Ribozyme Targeting Demonstrates That the Nuclear Receptor Coactivator AIB1 Is a Rate-limiting Factor for Estrogen-dependent Growth of Human MCF-7 Breast Cancer Cells

2001 • 135 citations

Vitamin A--functions, dietary requirements and safety in humans.

1997 • 132 citations

Multi-Institutional Phase I/II Trial of Oral Bexarotene in Combination With Cisplatin and Vinorelbine in Previously Untreated Patients With Advanced Non–Small-Cell Lung Cancer

2001 • 127 citations

Redifferentiation therapy-induced radioiodine uptake in thyroid cancer.

1998 • 119 citations

Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor β and estrogen receptor α genes in breast carcinoma cells

2001 • 119 citations

Combined Interferon-Alfa, 13-cis-Retinoic Acid, and Alpha-Tocopherol in Locally Advanced Head and Neck Squamous Cell Carcinoma: Novel Bioadjuvant Phase II Trial

2001 • 119 citations

Retinoic acid receptor-β: an endogenous inhibitor of the perinatal formation of pulmonary alveoli

2000 • 119 citations

RAR-independent RXR signaling induces t(15;17) leukemia cell maturation

1999 • 116 citations

c-Jun Can Mediate Androgen Receptor-induced Transactivation

1996 • 114 citations

Differentiating agents in pediatric malignancies: Retinoids in neuroblastoma

2000 • 112 citations

Orphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor β, Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells

2000 • 111 citations

Safety of the Synthetic Retinoid Fenretinide: Long-Term Results From a Controlled Clinical Trial for the Prevention of Contralateral Breast Cancer

2001 • 110 citations

Essential Roles of Retinoic Acid Signaling in Interdigital Apoptosis and Control of BMP-7 Expression in Mouse Autopods

1999 • 109 citations

Ligand-Activated Retinoic Acid Receptor Inhibits AP-1 Transactivation by Disrupting c-Jun/c-Fos Dimerization

1999 • 108 citations

Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia

2001 • 105 citations

Drug Approval Summaries: Arsenic Trioxide, Tamoxifen Citrate, Anastrazole, Paclitaxel, Bexarotene

2001 • 101 citations

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF–RAR α and NPM–RAR α

1999 • 95 citations

Therapeutic potential of selective modulators of nuclear receptor action

1998 • 91 citations

Chemoprevention of Skin Cancer in Xeroderma Pigmentosum

1992 • 88 citations

Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells.

2000 • 88 citations

Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.

1990 • 87 citations

Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity

2001 • 85 citations

Retinoids and ovarian cancer

2000 • 85 citations

Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption

1996 • 85 citations

Glucocorticoid Receptor Transcriptional Activity Determined by Spacing of Receptor and Nonreceptor DNA Sites

1998 • 85 citations

Stage-dependent responses of the developing lung to retinoic acid signaling.

2000 • 84 citations

Successful topical treatment of oral lichen planus and leukoplakias with fenretinide (4-HPR)

1994 • 82 citations

Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells.

2000 • 82 citations

Genomic Organization and Transcriptional Regulation of Human Apo2/TRAIL Gene

2000 • 76 citations

Topical Treatment of Cutaneous Lesions of Acquired Immunodeficiency Syndrome–Related Kaposi Sarcoma Using Alitretinoin Gel

2000 • 75 citations

Transcriptional Silencing Is Defined by Isoform- and Heterodimer-Specific Interactions between Nuclear Hormone Receptors and Corepressors

1998 • 74 citations

Unique anti-activator protein-1 activity of retinoic acid receptor beta.

2000 • 67 citations

Retinoic acid rescues inner ear defects in Hoxa1 deficient mice

2001 • 65 citations

Redifferentiation therapy with retinoic acid in follicular thyroid cancer.

1998 • 64 citations

Altered ligand binding and transcriptional regulation by mutations in the PML/RARα ligand-binding domain arising in retinoic acid–resistant patients with acute promyelocytic leukemia

2000 • 64 citations

SYSTEMIC RETINOID THERAPY

2001 • 63 citations

Retinoid chemoprevention in patients at high risk for skin cancer*

2001 • 61 citations

Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.

2001 • 60 citations

EMERGING NEW THERAPIES FOR CUTANEOUS T-CELL LYMPHOMA

2000 • 58 citations

The development of biologic end points in patients treated with differentiation agents: an experience of retinoids in prostate cancer.

2000 • 56 citations

Phase I trial of 9-cis retinoic acid in adults with solid tumors.

1996 • 55 citations

Anhydroretinol induces oxidative stress and cell death.

1999 • 53 citations

Topical tretinoin in actinic keratosis and basal cell carcinoma

1986 • 52 citations

Recent advances in cancer chemoprevention, with emphasis on breast and colorectal cancer

2000 • 52 citations

Induction of Fas expression and augmentation of Fas/Fas ligand-mediated apoptosis by the synthetic retinoid CD437 in human lung cancer cells.

2000 • 52 citations

Autonomous Rexinoid Death Signaling Is Suppressed by Converging Signaling Pathways in Immature Leukemia Cells

2001 • 49 citations

Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer.

2001 • 48 citations

Phase I Clinical Trial of Alitretinoin and Tamoxifen in Breast Cancer Patients: Toxicity, Pharmacokinetic, and Biomarker Evaluations

2001 • 47 citations

[Topical tretinoin in the treatment of lichen planus and leukoplakia of the mouth mucosa. A clinical evaluation].

1994 • 47 citations

Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors

2000 • 46 citations

Bexarotene ligand pharmaceuticals.

2000 • 43 citations

Regulation of Interferon and Retinoic Acid-induced Cell Death Activation through Thioredoxin Reductase

2001 • 42 citations

Accumulation of p53 protein and retinoic acid receptor beta in retinoid chemoprevention.

1997 • 41 citations

Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin).

2000 • 36 citations

Transforming growth factor ? (TGF-?) expression in dysplastic oral leukoplakia: Modulation by 13-cis retinoic acid

1999 • 30 citations

Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2

2001 • 29 citations

Efficacy of LGD1069 (Targretin), a retinoid X receptor-selective ligand, for treatment of uterine leiomyoma.

2000 • 29 citations

Fenretinide and cancer prevention

2000 • 27 citations

Fenretinide Therapy in Prostate Cancer: Effects on Tissue and Serum Retinoid Concentration

2000 • 26 citations

Interferon-alpha 2a, 13-cis-retinoic acid and radiotherapy for locally advanced carcinoma of the cervix: a pilot study.

1998 • 26 citations

Progressive 13-cis-retinoic acid dosage in the treatment of oral leukoplakia

1992 • 25 citations

Treatment of Kaposis Sarcoma

2001 • 20 citations

AIDS-related Kaposi's sarcoma: current treatment options, future trends.

2000 • 19 citations

Chemoprevention of cancer of uterine cervix: A study on chemoprevention of Retinamide II from cervical precancerous lesions

1997 • 16 citations

The biology of acute promyelocytic leukemia

2001 • 15 citations

A phase I-II study of 9-cis retinoic acid and interferon-α2b in patients with advanced renal-cell carcinoma: An NCIC Clinical Trials Group study

2000 • 15 citations

Cisplatin, vindesine, mitomycin-C and 13-cis retinoic acid in the treatment of advanced non small cell lung cancer. A phase II pilot study.

2000 • 14 citations

Treatment of Cervical Intraepithelial Neoplasia Levels 2 and 3 with Adapalene, a Retinoid-Related Molecule

2001 • 12 citations

Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer

2001 • 11 citations

Treatment of Kaposi's sarcoma.

2001 • 11 citations

[Topical tretinoin in the treatment of lichen planus and leukoplakia of the oral mucosa. A biochemical evaluation of the keratinization].

1994 • 8 citations

Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma.

2000 • 6 citations