Phase I Clinical Trial of Alitretinoin and Tamoxifen in Breast Cancer Patients: Toxicity, Pharmacokinetic, and Biomarker Evaluations

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease

1996 • 3,608 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

Lipid Alterations and Decline in the Incidence of Coronary Heart Disease in the Helsinki Heart Study

1988 • 946 citations

Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer.

1996 • 754 citations

Lipids and risk of coronary heart disease The Framingham Study

1992 • 545 citations

HIGH DENSITY LIPOPROTEIN CHOLESTEROL AS A PREDICTOR OF CARDIOVASCULAR DISEASE MORTALITY IN MEN AND WOMEN: THE FOLLOW-UP STUDY OF THE LIPID RESEARCH CLINICS PREVALENCE STUDY

1990 • 466 citations

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.

1992 • 446 citations

Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]

1992 • 421 citations

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

1993 • 394 citations

A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma.

1989 • 385 citations

Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women

1991 • 380 citations

Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years.

1989 • 357 citations

Experimental cancer of the lung.Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors

1967 • 357 citations

Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]

1992 • 307 citations

THE ROLES OF RETINOIDS IN VERTEBRATE DEVELOPMENT

1995 • 280 citations

Biologic Markers as Predictors of Clinical Outcome From Systemic Therapy for Primary Operable Breast Cancer

1999 • 225 citations

Changes in Plasma Lipids and Lipoproteins during Isotretinoin Therapy for Acne

1985 • 216 citations

Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen.

1994 • 198 citations

Retinoid Hyperostosis

1983 • 172 citations

Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea

1977 • 159 citations

Extraspinal Tendon and Ligament Calcification Associated with Long-Term Therapy with Etretinate

1986 • 154 citations

The effect of the anti-estrogen tamoxifen on cardiovascular risk factors in normal postmenopausal women.

1995 • 133 citations

Prediction of clinical outcome from primary tamoxifen by expression of biologic markers in breast cancer patients.

2000 • 115 citations

Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status

1993 • 114 citations

13- cis -Retinoic Acid: Inhibition of Bladder Carcinogenesis Induced in Rats by N -Butyl- N -(4-hydroxybutyl)nitrosamine

1977 • 112 citations

Perspectives on surrogate end points in the development of drugs that reduce the risk of cancer.

2000 • 108 citations

Osteoporosis Is a Toxic Effect of Long-term Etretinate Therapy

1995 • 100 citations

Abnormal Retinal Function Associated With Fenretinide, a Synthetic Retinoid

1986 • 91 citations

Effect of tamoxifen on plasma lipids and lipoproteins in postmenopausal women with breast cancer

1994 • 90 citations

Phase I/II trial of all-trans retinoic acid and tamoxifen in patients with advanced breast cancer.

1998 • 85 citations

The molecular and genetic dissection of the retinoid signalling pathway

1993 • 81 citations

Pharmacokinetics of all-trans-retinoic acid administered on an intermittent schedule.

1995 • 81 citations

Ten-Year Results of FAC Adjuvant Chemotherapy Trial in Breast Cancer

1989 • 81 citations

The efficacy of 9-cis retinoic acid in experimental models of cancer

1996 • 80 citations

Pilot Trial of the Safety, Tolerability, and Retinoid Levels of N-(4-hydroxyphenyl) Retinamide in Combination With Tamoxifen in Patients at High Risk for Developing Invasive Breast Cancer

2000 • 72 citations

Clinical course of patients with breast cancer with ten or more positive nodes who were treated with doxorubicin-containing adjuvant therapy

1992 • 69 citations

Effect of the Retinoid X Receptor-Selective Ligand LGD1069 on Mammary Carcinoma After Tamoxifen Failure

1999 • 68 citations

Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.

1996 • 67 citations

A phase II trial of all- trans -retinoic acid in hormone-refractory prostate cancer: a clinical trial with detailed pharmacokinetic analysis

1997 • 64 citations

Effect of the Synthetic Retinoid Fenretinide on Dark Adaptation and the Ocular Surface

1994 • 64 citations

Chemoprevention of MNU-induced mammary tumors in the mature rat by 4-HPR and tamoxifen.

1992 • 61 citations

Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)

1999 • 61 citations

A sequential comparison of etretinate (TigasonR) and isotretinoin (RoaccutaneR) with special regard to their effects on serum lipoproteins

1985 • 58 citations

Responses to retinoic acid of tamoxifen-sensitive and -resistant sublines of human breast cancer cell line MCF-7.

1992 • 56 citations

Skeletal Deformities following Chronic Hypervitaminosis A

1974 • 55 citations

Phase I trial of 9-cis retinoic acid in adults with solid tumors.

1996 • 55 citations

Hyperlipidaemia due to isotretinoin and etretinate: possible mechanisms and consequences

1986 • 50 citations

Steroid receptors and response to endocrine ablations in women with metastatic cancer of the breast

1980 • 48 citations

Skeletal Hyperostosis in Patients Receiving Chronic, Very-Low-Dose Isotretinoin

1992 • 43 citations

Bone Mineral Density of the Lumbar Spine in Psoriatic Patients with Long Term Etretinate Therapy

1994 • 39 citations

Effects of long-term intake of retinol on selected clinical and laboratory indexes

1999 • 35 citations

Tamoxifen and fenretinide in women with metastatic breast cancer

1999 • 34 citations

Phase I study of 9-cis-retinoic acid (ALRT1057 capsules) in adults with advanced cancer.

1998 • 31 citations

Effects of Fenretinide (4-HPR) on Dark Adaptation

1998 • 30 citations

Effects of chronic administration of N-(4-hydroxyphenyl)retinamide (4-HPR) in rats on vitamin A metabolism in the eye

1996 • 13 citations

The effect of the Anti-Estrogen Tamoxifen on Cardiovascular Risk Factors in Normal Postmenopausal Women

1996 • 8 citations