Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells

How MAP Kinases Are Regulated

1995 • 1,742 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Laminar Shear Stress

1998 • 1,052 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure.

1974 • 932 citations

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

1994 • 800 citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 • 688 citations

Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

1998 • 569 citations

Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways

2000 • 497 citations

Calcium Mobilization and Exocytosis After One Mechanical Stretch of Lung Epithelial Cells

1990 • 494 citations

The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

2000 • 411 citations

Stretch induces cytokine release by alveolar epithelial cells in vitro

1999 • 391 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1995 • 359 citations

Deformation-Induced Injury of Alveolar Epithelial Cells

2000 • 334 citations

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

1993 • 290 citations

Fluid Shear Stress Stimulates Mitogen-Activated Protein Kinase in Endothelial Cells

1995 • 287 citations

Mechanical force-induced signal transduction in lung cells

1999 • 286 citations

Control of the eukaryotic cell cycle by MAP kinase signaling pathways

2000 • 285 citations

Mechanical stress-initiated signal transductions in vascular smooth muscle cells

2000 • 281 citations

Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways

1999 • 271 citations

Differential Effect of Shear Stress on Extracellular Signal-regulated Kinase and N-terminal Jun Kinase in Endothelial Cells

1997 • 269 citations

Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress

1998 • 216 citations

Acute hypertension activates mitogen-activated protein kinases in arterial wall.

1996 • 200 citations

β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf

2000 • 174 citations

Role of Ion Channels and Exchangers in Mechanical Stretch–Induced Cardiomyocyte Hypertrophy

1998 • 160 citations

[Ca²⁺]_i oscillations regulate type II cell exocytosis in the pulmonary alveolus

2000 • 157 citations

Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor

2000 • 117 citations

Mechanical stimulation of skeletal muscle increases prostaglandin F_2α production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism

1995 • 108 citations

Equibiaxial strain and strain rate stimulate early activation of G proteins in cardiac fibroblasts

1998 • 98 citations

Differential expression of Na-K-ATPase isoforms in rat alveolar epithelial cells

1997 • 84 citations

Cyclic stretch induces both apoptosis and secretion in rat alveolar type II cells

1999 • 78 citations

Mechanical strain-induced proliferation and signaling in pulmonary epithelial H441 cells

2000 • 74 citations

Mechanical stretching of alveolar epithelial cells increases Na⁺-K⁺-ATPase activity

1999 • 66 citations

Influence of Strain on [³H]thymidine Incorporation, Surfactant-related Phospholipid Synthesis, and cAMP Levels in Fetal Type II Alveolar Cells

1993 • 65 citations

Differential regulation of extracellular matrix molecules by mechanical strain of fetal lung cells

1999 • 51 citations

Stretch-Induced Mitogen-Activated Protein Kinase Activation and Interleukin-8 Production in Type II Alveolar Cells

1999 • 50 citations

Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain

1999 • 44 citations

Deleted Work

1955 • 0 citations