Role of genetic and epigenetic changes in Burkitt lymphoma

p53: puzzle and paradigm.

1996 • 2,363 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

The INK4a/ARF network in tumour suppression

2001 • 956 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma

1993 • 680 citations

Myc activates telomerase

1998 • 650 citations

Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men

1983 • 517 citations

twist is a potential oncogene that inhibits apoptosis

1999 • 511 citations

The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

2000 • 479 citations

Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

2000 • 470 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

2000 • 447 citations

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

1996 • 434 citations

Molecular Biology of Burkitt’s Lymphoma

2000 • 432 citations

Myc represses the p21 ^(WAF1/CIP1) promoter and interacts with Sp1/Sp3

2001 • 411 citations

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1999 • 366 citations

DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

2000 • 353 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 319 citations

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

1999 • 285 citations

BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.

2001 • 284 citations

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover

2000 • 276 citations

Repression of transcription of the p27Kip1 cyclin-dependent kinase inhibitor gene by c-Myc

2001 • 267 citations

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma

2001 • 263 citations

p53 is frequently mutated in Burkitt's lymphoma cell lines.

1991 • 259 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 248 citations

Burkitt Lymphoma in the Mouse

2000 • 209 citations

Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia

2000 • 204 citations

Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis

2001 • 181 citations

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

1998 • 177 citations

Involvement of Myc Activity in a G₁/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

2000 • 165 citations

Role of p73 in malignancy: tumor suppressor or oncogene?

2002 • 153 citations

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16^INK4aand p19^ARF, is a candidate for the plasmacytoma susceptibility locus,Pctr1

1998 • 148 citations

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19^ARF–p53 signaling

2002 • 143 citations

Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1

1999 • 141 citations

The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

2001 • 139 citations

Frequent Methylation Silencing of p15INK4b(MTS2) and p16INK4a (MTS1) in B-Cell and T-Cell Lymphomas

1999 • 137 citations

E2F Transcriptional Activation Requires TRRAP and GCN5 Cofactors

2001 • 128 citations

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells

1998 • 127 citations

The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors.

1992 • 113 citations

Epstein-Barr Virus Small RNAs Potentiate Tumorigenicity of Burkitt Lymphoma Cells Independently of an Effect on Apoptosis

2000 • 110 citations

Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas

2001 • 104 citations

INK4a/ARFLocus Alterations in Human Non-Hodgkin's Lymphomas Mainly Occur in Tumors with Wild-Type p53 Gene

2000 • 103 citations

DAP Kinase—A Proapoptotic Gene That Functions as a Tumor Suppressor

2001 • 99 citations

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

2001 • 98 citations

p16/INK4a and p15/INK4b Gene Methylation and Absence of p16/INK4a mRNA and Protein Expression in Burkitt's Lymphoma

1998 • 89 citations

Efficiency Alleles of the Pctr1 Modifier Locus for Plasmacytoma Susceptibility

2001 • 84 citations

Overall Survival in Aggressive B-Cell Lymphomas Is Dependent on the Accumulation of Alterations in p53, p16, and p27

2001 • 83 citations

p53-Induced Apoptosis as a Safeguard against Cancer

1999 • 81 citations

Genetic Alterations of the Retinoblastoma-Related Gene RB2/p130 Identify Different Pathogenetic Mechanisms in and among Burkitt's Lymphoma Subtypes

2000 • 79 citations

Immunolocalization of Human p14ARF to the Granular Component of the Interphase Nucleolus

2000 • 78 citations

Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors.

2000 • 76 citations

Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240.

1991 • 74 citations

Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.

1999 • 67 citations

The role of EBERs in oncogenesis

2001 • 57 citations

Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells.

1997 • 53 citations

Infrequent p53 mutation in mouse tumors with deregulated myc.

1992 • 40 citations

Biological Activities of p53 Mutants in Burkitt's Lymphoma Cells

1993 • 35 citations

Point mutations of the BCL‐6 gene in Burkitt's lymphoma

1997 • 33 citations

Inactivation of Myc-induced p53-dependent apoptosis in human tumors.

2001 • 32 citations

Dysregulation of lymphocyte proliferation by chromosomal translocations and sequential genetic changes

2000 • 17 citations

Loss of functional pRB is not a ubiquitous feature of B-cell malignancies

1999 • 8 citations

The Role of p16INK4a (Cdkn2a) in Mouse Plasma Cell Tumors

1999 • 8 citations