Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

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1995 • 4,589 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

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PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

Embryonic Stem Cells Express Neuronal Properties in Vitro

1995 • 1,173 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutants

1994 • 755 citations

Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase

2000 • 749 citations

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.

1995 • 651 citations

Function of GATA Transcription Factors in Preadipocyte-Adipocyte Transition

2000 • 496 citations

Regulation of Peroxisome Proliferator-activated Receptor γ Activity by Mitogen-activated Protein Kinase

1997 • 446 citations

Differentiation of embryonic stem cells into adipocytes in vitro

1997 • 427 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

Peroxisome Proliferator Activated Receptor γ, CCAAT/ Enhancer-binding Protein α, and Cell Cycle Status Regulate the Commitment to Adipocyte Differentiation

1997 • 272 citations

Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis.

1995 • 269 citations

Induction of Cellular Differentiation by Retinoic Acid in vitro

1999 • 209 citations

Mitogen-Activated Protein Kinase Activation Is Not Necessary for, but Antagonizes, 3T3-L1 Adipocytic Differentiation

1997 • 176 citations

The JUN Kinase/Stress-activated Protein Kinase Pathway Is Required for Epidermal Growth Factor Stimulation of Growth of Human A549 Lung Carcinoma Cells

1997 • 174 citations

Leukemia Inhibitory Factor and Its Receptor Promote Adipocyte Differentiation via the Mitogen-activated Protein Kinase Cascade

1999 • 121 citations

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

1993 • 115 citations

Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH₂-Terminal Kinase-Specific Kinase

1997 • 108 citations

Loss of β1Integrin Function Results in a Retardation of Myogenic, but an Acceleration of Neuronal, Differentiation of Embryonic Stem Cellsin Vitro

1998 • 105 citations

In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid

1994 • 101 citations

All-trans-Retinoic Acid Inhibits Jun N-Terminal Kinase by Increasing Dual-Specificity Phosphatase Activity

1999 • 95 citations

An in vitro Pathway from Embryonic Stem Cells to Neurons and Glia

1999 • 86 citations

Embryonic Stem Cell-Derived Adipogenesis

1999 • 72 citations

c-Jun Amino-terminal Kinase Is Regulated by Gα12/Gα13 and Obligate for Differentiation of P19 Embryonal Carcinoma Cells by Retinoic Acid

1997 • 66 citations

Retinoic acid selectively activates the ERK2 but not JNK/SAPK or P38 map kinases when inducing myeloid differentiation

1999 • 55 citations

Cross-talk between the Platelet-derived Growth Factor and the Insulin Signaling Pathways in 3T3-L1 Adipocytes

1997 • 51 citations

Establishment of Ionic Channels and Signalling Cascades in the Embryonic Stem Cell-Derived Primitive Endoderm and Cardiovascular System

1999 • 47 citations

Differential Effect of Retinoic Acid on Growth Regulation by Phorbol Ester in Human Cancer Cell Lines

1999 • 39 citations

MEKK4 Mediates Differentiation in Response to Retinoic Acid via Activation of c-Jun N-terminal Kinase in Rat Embryonal Carcinoma P19 Cells

2000 • 35 citations

RETINOIC ACID INCREASES AMOUNT OF PHOSPHORYLATED RAF; ECTOPIC EXPRESSION OF cFMS REVEALS THAT RETINOIC ACID-INDUCED DIFFERENTIATION IS MORE STRONGLY DEPENDENT ON ERK2 SIGNALING THAN INDUCED G0 ARREST IS

2000 • 29 citations

Molecular genetic approaches to microtubule-associated protein function.

2000 • 19 citations

Alltrans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity

1999 • 6 citations