Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE

1975 • 2,653 citations

Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction

1988 • 1,722 citations

HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study.

1977 • 1,517 citations

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment.

1992 • 1,341 citations

Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state.

1992 • 1,146 citations

Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?

1990 • 1,020 citations

Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome

1991 • 930 citations

Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience)

1992 • 895 citations

Fructose-induced insulin resistance and hypertension in rats.

1987 • 885 citations

CORONARY-HEART-DISEASE RISK AND IMPAIRED GLUCOSE TOLERANCE The Whitehall Study

1980 • 800 citations

Epidemiology as a Guide to Clinical Decisions

1980 • 708 citations

Plasma triglyceride and coronary heart disease.

1991 • 707 citations

Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles.

1993 • 696 citations

Cardiovascular Risk Factors in Confirmed Prediabetic Individuals

1990 • 608 citations

Insulin and Atheroma: 20-Yr Perspective

1990 • 584 citations

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

1991 • 572 citations

Role of Insulin in Endogenous Hypertriglyceridemia*

1967 • 523 citations

Effects of Weight Reduction on Obesity STUDIES OF LIPID AND CARBOHYDRATE METABOLISM IN NORMAL AND HYPERLIPOPROTEINEMIC SUBJECTS

1974 • 520 citations

Reappraisal of the role of insulin in hypertriglyceridemia

1974 • 480 citations

Racial Differences in the Relation between Blood Pressure and Insulin Resistance

1991 • 427 citations

Plasma Triglyceride Level and Mortality from Coronary Heart Disease

1993 • 425 citations

Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group.

1993 • 324 citations

Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*

1987 • 311 citations

Elevated fibrinogen and plasminogen activator inhibitor (PAI‐1) in hypertension are related to metabolic risk factors for cardiovascular disease

1990 • 309 citations

Evidence for an independent relationship between insulin resistance and fasting plasma HDL‐cholesterol, triglyceride and insulin concentrations

1992 • 289 citations

Glucose, insulin, and triglyceride responses to high and low carbohydrate diets in man.

1966 • 261 citations

Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic man

1981 • 249 citations

The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin resistance

1993 • 226 citations

Additive Hypoglycemic Effects of Drugs That Modify Free-Fatty Acid Metabolism by Different Mechanisms in Rats With Streptozocin-Induced Diabetes

1988 • 210 citations

Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent

1991 • 209 citations

Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance

1989 • 177 citations

Somatostatin inhibition of fructose-induced hypertension.

1989 • 157 citations

Role of insulin in regulation of lipoprotein metabolism in diabetes

1988 • 155 citations

Attenuation of fructose-induced hypertension in rats by exercise training.

1988 • 153 citations

Insulin Resistance and Insulin Secretion Are Determinants of Oral Glucose Tolerance in Normal Individuals

1993 • 152 citations

Insulin resistance and blood pressure in young black men.

1990 • 147 citations

Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride

1985 • 141 citations

Differences in postprandial lipemia between patients with normal glucose tolerance and noninsulin-dependent diabetes mellitus.

1993 • 140 citations

Sustained hyperinsulinemia increases arterial pressure in conscious rats

1991 • 135 citations

Relationship between lipoprotein levels and in vivo insulin action in normal young white men

1988 • 131 citations

Insulin Resistance, Hyperinsulinemia, and Dyslipidemia in Nonobese Individuals With a Family History of Hypertension

1992 • 124 citations

Abnormalities of carbohydrate and lipid metabolism in Dahl rats.

1991 • 118 citations

Relationship Between Insulin Resistance and Hypertension

1991 • 115 citations

Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines?

1990 • 114 citations

Relationship Between Blood Pressure, Plasma Insulin ana Triglyceride Concentration, and Insulin Action in Spontaneous Hypertensive and Wistar-Kyoto Rats

1991 • 98 citations

In defence of insulin: a critique of syndrome X

1992 • 89 citations

Insulin resistance and risk factors for coronary heart disease

1993 • 88 citations

Why is insulin not a risk factor for coronary heart disease?

1994 • 83 citations

Insulin Resistance in Secondary Hypertension

1992 • 74 citations

Relation of fasting plasma insulin concentration to high density lipoprotein cholesterol and triglyceride concentrations in men.

1991 • 69 citations

Insulin-stimulated glucose utilization and borderline hypertension in young adult blacks.

1993 • 62 citations

Relationship of Postload Plasma Glucose to Mortality With 19-Yr Follow-Up. Comparison of one versus two plasma glucose measurements in the Chicago Peoples Gas Company Study

1992 • 58 citations

Insulin Resistance and Abnormal Electrocardiograms in Patients With High Blood Pressure

1992 • 52 citations

Abnormalities of Insulin and Lipid Metabolism in Milan Hypertensive Rats

1991 • 45 citations

Are triglycerides important as a risk factor for coronary disease?

1993 • 26 citations

Deleted Work

1955 • 0 citations