Response toNeisseria gonorrhoeaeby Cervicovaginal Epithelial Cells Occurs in the Absence of Toll-Like Receptor 4-Mediated Signaling

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 • 2,188 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

1999 • 1,570 citations

Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2

1999 • 1,500 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

2000 • 1,246 citations

Discrimination of bacterial lipoproteins by Toll-like receptor 6

2001 • 1,222 citations

BIOCHEMISTRY OF ENDOTOXINS

1990 • 1,201 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products

1999 • 939 citations

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

1993 • 845 citations

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

1999 • 813 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors

2000 • 754 citations

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

1994 • 747 citations

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

2000 • 744 citations

CD14 Is a pattern recognition receptor

1994 • 706 citations

Soluble CD14 participates in the response of cells to lipopolysaccharide.

1992 • 695 citations

Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide

2001 • 672 citations

Cutting Edge: Inflammatory Signaling byBorrelia burgdorferiLipoproteins Is Mediated by Toll-Like Receptor 2

1999 • 666 citations

Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium

1999 • 639 citations

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 • 604 citations

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 • 581 citations

Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells

2000 • 556 citations

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

2001 • 477 citations

Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages

2000 • 473 citations

The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

1999 • 445 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

Inducible Expression of Human β-Defensin 2 byFusobacterium nucleatumin Oral Epithelial Cells: Multiple Signaling Pathways and Role of Commensal Bacteria in Innate Immunity and the Epithelial Barrier

2000 • 406 citations

Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling

2001 • 388 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.

1998 • 321 citations

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium

2000 • 309 citations

The Molecular Basis of Nonoxynol‐9–Induced Vaginal Inflammation and Its Possible Relevance to Human Immunodeficiency Virus Type 1 Transmission

2001 • 305 citations

Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line

2001 • 300 citations

Generation of Papillomavirus-Immortalized Cell Lines from Normal Human Ectocervical, Endocervical, and Vaginal Epithelium that Maintain Expression of Tissue-Specific Differentiation Proteins1

1997 • 299 citations

Human Toll-Like Receptor 2 Mediates Monocyte Activation byListeria monocytogenes, But Not by Group B Streptococci or Lipopolysaccharide

2000 • 292 citations

Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses

2001 • 267 citations

Binding of Bacterial Peptidoglycan to CD14

1998 • 265 citations

Mucin Genes Expressed by Human Female Reproductive Tract Epithelia1

1997 • 245 citations

Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide.

1994 • 236 citations

Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.

1993 • 211 citations

Transcriptional Regulation of β-Defensin Gene Expression in Tracheal Epithelial Cells

2000 • 205 citations

Differential Expression of Immunobiological Mediators by Immortalized Human Cervical and Vaginal Epithelial Cells1

1999 • 192 citations

Bacterial Fimbriae and Their Peptides Activate Human Gingival Epithelial Cells through Toll-Like Receptor 2

2001 • 178 citations

Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses.

1995 • 177 citations

Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures

1994 • 175 citations

Elevated Levels of Serum-Soluble CD14 in Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Correlation to Disease Progression and Clinical Events

1998 • 166 citations

Short-Term, High-Efficiency Expression of Transfected DNA

1984 • 166 citations

Distinct Proinflammatory Host Responses to Neisseria gonorrhoeae Infection in Immortalized Human Cervical and Vaginal Epithelial Cells

2001 • 151 citations

The Role of CD14 in Signaling Mediated by Outer Membrane Lipoproteins ofBorrelia burgdorferi

1998 • 147 citations

The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family¹

1997 • 135 citations

CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.

1994 • 120 citations

A Mycoplasma fermentans-derived Synthetic Lipopeptide Induces AP-1 and NF-κB Activity and Cytokine Secretion in Macrophages via the Activation of Mitogen-activated Protein Kinase Pathways

1998 • 119 citations

Estrogen Receptor Localization in the Female Genital Tract

1987 • 118 citations

Expression of Lung Vascular and Airway ICAM-1 after Exposure to Bacterial Lipopolysaccharide

1997 • 115 citations

Molecular characterization and modular analysis of human MyD88.

1996 • 110 citations

Elimination of trace endotoxin protein from rough chemotype LPS

1994 • 106 citations

The Amount of MUC5B Mucin in Cervical Mucus Peaks at Midcycle¹

2001 • 103 citations

Mucosal immunity in the female reproductive tract: correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation.

1998 • 96 citations

CELLS AND CYTOKINES IN MUCOSAL IMMUNITY AND INFLAMMATION

1992 • 89 citations

Activation of Human Monocytic Cells by Borrelia burgdorferi and Treponema pallidum Is Facilitated by CD14 and Correlates with Surface Exposure of Spirochetal Lipoproteins

1999 • 83 citations

Genetic Subtypes of HIV Type 1 and HIV Type 2 Strains in Commercial Sex Workers from Bamako, Mali

1998 • 80 citations

Short-term, high-efficiency expression of transfected DNA.

1984 • 80 citations

The Amount of MUC5B Mucin in Cervical Mucus Peaks at Midcycle

2001 • 80 citations

Application of a Mycoplasma group-specific PCR for monitoring decontamination of Mycoplasma-infected Chlamydia sp. strains

1996 • 79 citations

Membrane-Associated Proteins of a Lipopolysaccharide-Deficient Mutant ofNeisseria meningitidisActivate the Inflammatory Response through Toll-Like Receptor 2

2001 • 76 citations

Quantitation of mediators of inflammation and immunity in genital tract secretions and their relevance to HIV type 1 transmission.

1998 • 62 citations

Optimization of the Weck-Cel Collection Method for Quantitation of Cytokines in Mucosal Secretions

2000 • 51 citations

Infection and Preterm Labor

2000 • 38 citations

Regulation of nitric oxide production in cultured human T84 intestinal epithelial cells by nuclear factor‐κB‐dependent induction of inducible nitric oxide synthase after exposure to bacterial endotoxin

2000 • 32 citations

Modulation of HLA‐DR antigens in the gingival epithelium in vitro by heat‐killed Fusobacterium nucleatum and E. coli lipopolysaccharide

1985 • 27 citations

Effects of Bacterial Lipopolysaccharides (LPS) and Tumour Necrosis Factor-α (TNFα) on Rat Tracheal Epithelial Cells in Culture: Morphology, Proliferation and Induction of Nitric Oxide (NO) Synthase

1996 • 25 citations

REGULATION OF INTERLEUKIN 6 PRODUCTION IN A HUMAN GASTRIC EPITHELIAL CELL LINE MKN-28

2000 • 20 citations

Immunology: High concentrations of the soluble p55 tumour necrosis factor receptor in human seminal plasma

1993 • 16 citations

Epithelial cell response to challenge of bacterial lipoteichoic acids and lipopolysaccharides in vitro

2000 • 14 citations