Activation of Human Monocytic Cells by Borrelia burgdorferi and Treponema pallidum Is Facilitated by CD14 and Correlates with Surface Exposure of Spirochetal Lipoproteins

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1993 • 845 citations

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1992 • 695 citations

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1988 • 654 citations

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1996 • 562 citations

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1990 • 279 citations

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1992 • 273 citations

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1989 • 257 citations

Absence of lipopolysaccharide in the Lyme disease spirochete, Borrelia burgdorferi

1987 • 256 citations

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Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages.

1995 • 229 citations

CD14 and innate recognition of bacteria.

1995 • 224 citations

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1996 • 222 citations

Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.

1993 • 211 citations

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1998 • 201 citations

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1993 • 191 citations

Identification and localization of integral membrane proteins of virulent Treponema pallidum subsp. pallidum by phase partitioning with the nonionic detergent triton X-114

1988 • 179 citations

Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct.

1991 • 158 citations

Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B

1996 • 149 citations

The Role of CD14 in Signaling Mediated by Outer Membrane Lipoproteins ofBorrelia burgdorferi

1998 • 147 citations

Arthropod- and host-specific gene expression by Borrelia burgdorferi.

1997 • 147 citations

Major integral membrane protein immunogens of Treponema pallidum are proteolipids

1989 • 143 citations

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1997 • 126 citations

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1999 • 116 citations

Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.

1994 • 112 citations

Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-kappa B and inflammatory activation in human endothelial cells.

1996 • 111 citations

Treponema pallidum and the quest for outer membrane proteins

1995 • 104 citations

A Region of Human CD14 Required for Lipopolysaccharide Binding

1995 • 103 citations

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1995 • 99 citations

Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils.

1997 • 97 citations

Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages.

1995 • 94 citations

Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.

1998 • 92 citations

Virulent Treponema pallidum Activates Human Vascular Endothelial Cells

1992 • 87 citations

Bacterial Lipopolysaccharide Can Enter Monocytes Via Two CD14-Dependent Pathways

1998 • 86 citations

Outer surface lipoproteins of Borrelia burgdorferi activate vascular endothelium in vitro

1996 • 85 citations

Construction of a Lipopolysaccharide Reporter Cell Line and Its Use in Identifying Mutants Defective in Endotoxin, But Not TNF-α, Signal Transduction

1998 • 83 citations

Mutation of Amino Acids 39–44 of Human CD14 Abrogates Binding of Lipopolysaccharide and Escherichia coli

1997 • 83 citations

Cell Activation Mediated by Glycosylphosphatidylinositol-Anchored or Transmembrane Forms of CD14

1998 • 83 citations

In vitro and in vivo induction of tumor necrosis factor alpha by Borrelia burgdorferi

1992 • 81 citations

Identification of a Domain in Soluble CD14 Essential for Lipopolysaccharide (LPS) Signaling but Not LPS Binding

1995 • 70 citations

Both membrane‐bound and soluble forms of CD14 bind to Gram‐negative bacteria

1995 • 64 citations

A Subpopulation of Treponema pallidum Is Resistant to Phagocytosis: Possible Mechanism of Persistence

1992 • 60 citations

The CD14 differentiation antigen mediates the development of endotoxin responsiveness during differentiation of mononuclear phagocytes

1994 • 58 citations

Lyme arthritis synovial gamma delta T cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides.

1998 • 54 citations

The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor

1996 • 53 citations

Membrane topology of Borrelia burgdorferi and Treponema pallidum lipoproteins

1995 • 49 citations

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1998 • 42 citations

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1999 • 36 citations

Potent CD14-mediated signalling of human leukocytes by Escherichia coli can be mediated by interaction of whole bacteria and host cells without extensive prior release of endotoxin

1996 • 35 citations

Phagocytosis of opsonized Treponema pallidum subsp. pallidum proceeds slowly

1990 • 32 citations

The outer surface lipoprotein OspA of Borrelia burgdorferi provides co‐stimulatory signals to normal human peripheral CD4⁺ and CD8⁺ T lymphocytes

1996 • 22 citations

Deleted Work

1955 • 0 citations