Pathophysiology of obsessive–compulsive disorder
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Abstract
References (345)
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex
1986 • 8,208 citations
Emotion Circuits in the Brain
2000 • 8,055 citations
Cognitive and emotional influences in anterior cingulate cortex
2000 • 6,010 citations
The functional anatomy of basal ganglia disorders
1989 • 5,166 citations
Predictive Reward Signal of Dopamine Neurons
1998 • 4,446 citations
Specific impairments of planning
1982 • 3,603 citations
A PROPOSED MECHANISM OF EMOTION
1937 • 3,511 citations
Contributions of anterior cingulate cortex to behaviour
1995 • 3,315 citations
Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance
1998 • 3,235 citations
Psychopharmacology: The Fourth Generation of Progress
1995 • 2,920 citations
A Neural System for Error Detection and Compensation
1993 • 2,813 citations
Lifetime Prevalence of Specific Psychiatric Disorders in Three Sites
1984 • 2,591 citations
Drug Abuse: Hedonic Homeostatic Dysregulation
1997 • 2,472 citations
Frontal-Subcortical Circuits and Human Behavior
1993 • 2,248 citations
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
1995 • 2,101 citations
Conflict monitoring versus selection-for-action in anterior cingulate cortex
1999 • 2,027 citations
Temporal dynamics of brain activation during a working memory task
1997 • 1,879 citations
Memory and Brain
1987 • 1,821 citations
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
2001 • 1,673 citations
The Orbitofrontal Cortex and Reward
2000 • 1,574 citations
Dissociation in prefrontal cortex of affective and attentional shifts
1996 • 1,527 citations
The neostriatal mosaic: multiple levels of compartmental organization
1992 • 1,450 citations
Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidium in basal ganglia circuitry
1995 • 1,339 citations
The Epidemiology of Obsessive-Compulsive Disorder in Five US Communities
1988 • 1,323 citations
Neuroimaging studies of mood disorders
2000 • 1,303 citations
The Basal Ganglia and Adaptive Motor Control
1994 • 1,295 citations
Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder
1992 • 1,283 citations
The Brain and Emotion
1998 • 1,275 citations
A functional anatomical study of unipolar depression
1992 • 1,266 citations
Localization of a Neural System for Error Detection and Compensation
1994 • 1,262 citations
Neurobehavioural mechanisms of reward and motivation
1996 • 1,177 citations
Spatial working memory in humans as revealed by PET
1993 • 1,169 citations
The amygdala and reward
2002 • 1,156 citations
"Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?
1998 • 1,145 citations
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
2001 • 1,136 citations
The spectrum of behaviors influenced by serotonin
1998 • 1,126 citations
Dopamine and the regulation of cognition and attention
2002 • 1,069 citations
Dorsal anterior cingulate cortex: A role in reward-based decision making
2001 • 1,062 citations
A Neural Basis for General Intelligence
2000 • 1,037 citations
A family study of obsessive-compulsive disorder
1995 • 1,036 citations
Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory.
1973 • 1,007 citations
The Neostriatal Mosaic: Multiple Levels of Compartmental Organization in the Basal Ganglia
1992 • 1,005 citations
Responses of monkey dopamine neurons during learning of behavioral reactions
1992 • 986 citations
The Frontal Lobes and Voluntary Action
1993 • 984 citations
Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque
1999 • 968 citations
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
2000 • 962 citations
Regional Cerebral Blood Flow Measured During Symptom Provocation in Obsessive-Compulsive Disorder Using Oxygen 15—Labeled Carbon Dioxide and Positron Emission Tomography
1994 • 888 citations
Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder
1987 • 855 citations
Building Neural Representations of Habits
1999 • 842 citations
The orbitofrontal cortex: Neuronal activity in the behaving monkey
1983 • 834 citations
Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder
1998 • 823 citations
Serotonin-dopamine interaction and its relevance to schizophrenia
1996 • 822 citations
Obsessive-Compulsive Disorder in Children and Adolescents
1989 • 820 citations
Structure and function of dopamine receptors
2000 • 793 citations
Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine
2002 • 783 citations
Fear and the brain: where have we been, and where are we going?
1998 • 779 citations
Symptoms of obsessive-compulsive disorder
1997 • 770 citations
Some psychiatric implications of physiological studies on frontotemporal portion of limbic system (Visceral brain)
1952 • 764 citations
Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity
1970 • 760 citations
The Cerebrocerebellar System
1997 • 751 citations
Associative Processes in Addiction and Reward The Role of Amygdala‐Ventral Striatal Subsystems
1999 • 713 citations
Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
1993 • 713 citations
Tourette syndrome, associated conditions and the complexities of treatment
2000 • 694 citations
Systematic Changes in Cerebral Glucose Metabolic Rate After Successful Behavior Modification Treatment of Obsessive-Compulsive Disorder
1996 • 691 citations
Obsessive Compulsive Disorder in Adolescence: An Epidemiological Study
1988 • 689 citations
Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder
1989 • 676 citations
Use of Factor-Analyzed Symptom Dimensions to Predict Outcome With Serotonin Reuptake Inhibitors and Placebo in the Treatment of Obsessive-Compulsive Disorder
1999 • 673 citations
Pathophysiological Basis of Vulnerability to Drug Abuse: Role of an Interaction Between Stress, Glucocorticoids, and Dopaminergic Neurons
1996 • 671 citations
Role for Cingulate Motor Area Cells in Voluntary Movement Selection Based on Reward
1998 • 649 citations
A Family Study of Obsessive-compulsive Disorder
2000 • 646 citations
Clinical characteristics and family history in DSM-III obsessive- compulsive disorder
1986 • 643 citations
Functional Magnetic Resonance Imaging of Symptom Provocation in Obsessive-compulsive Disorder
1996 • 624 citations
Expectation of reward modulates cognitive signals in the basal ganglia
1998 • 621 citations
A 40-Year Follow-up of Patients With Obsessive-compulsive Disorder
1999 • 618 citations
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning
1994 • 590 citations
Body dysmorphic disorder: 30 cases of imagined ugliness
1993 • 570 citations
Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder
1988 • 551 citations
Gilles de la Tourette's Syndrome and Obsessive-Compulsive Disorder
1986 • 550 citations
Mapping the Mind
1998 • 548 citations
Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder
1990 • 546 citations
Integration of diverse information in working memory within the frontal lobe
2000 • 544 citations
Neurobiology of Mental Illness
2011 • 532 citations
Characteristics of 60 adult chronic hair pullers
1991 • 531 citations
A Double-blind, Placebo-Controlled Study of Risperidone Addition in Serotonin Reuptake Inhibitor–Refractory Obsessive-compulsive Disorder
2000 • 530 citations
The relationship of obsessive–compulsive disorder to possible spectrum disorders: results from a family study
2000 • 526 citations
Prefrontal and cingulate unit activity during timing behavior in the monkey
1979 • 504 citations
Mechanism of action of serotonin selective reuptake inhibitors
1998 • 497 citations
Contributions of the prefrontal cortex to the neural basis of human decision making
2002 • 497 citations
The Epidemiology and Differential Diagnosis of Obsessive-Compulsive Disorder
1992 • 490 citations
A System for Relational Reasoning in Human Prefrontal Cortex
1999 • 483 citations
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
1998 • 478 citations
Thalamic Relay Nuclei of the Basal Ganglia Form Both Reciprocal and Nonreciprocal Cortical Connections, Linking Multiple Frontal Cortical Areas
2002 • 475 citations
Factor analysis of symptom subtypes of obsessive compulsive disorder and their relation to personality and tic disorders.
1994 • 461 citations
Working Memory and the Mind
1992 • 458 citations
Tourette's Syndrome
2001 • 449 citations
A Review of the Efficacy of Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder
1999 • 447 citations
Functional Anatomy of Obsessive–Compulsive Phenomena
1994 • 445 citations
Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive- compulsive disorder
1989 • 430 citations
Organizational strategies mediate nonverbal memory impairment in obsessive–compulsive disorder
1999 • 427 citations
Body dysmorphic disorder: the distress of imagined ugliness
1991 • 425 citations
High prevalence of obsessive-compulsive symptoms in patients with Sydenham's chorea
1989 • 423 citations
Clomipramine and Exposure for Obsessive-Compulsive Rituals: 1
1980 • 421 citations
Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility
1993 • 421 citations
Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder
1992 • 418 citations
Gambling Urges in Pathological Gambling
2003 • 410 citations
Highly restricted origin of prefrontal cortical inputs to striosomes in the macaque monkey
1995 • 390 citations
Estimated lifetime prevalence of trichotillomania in college students.
1991 • 389 citations
Cerebral glucose metabolic rates in obsessive compulsive disorder
1989 • 387 citations
Axis I comorbidity in body dysmorphic disorder
2003 • 383 citations
Influence of Reward Expectation on Behavior-Related Neuronal Activity in Primate Striatum
1998 • 381 citations
Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever
1997 • 378 citations
Serotonergic Responsivity in Obsessive-Compulsive Disorder
1987 • 378 citations
Modification of expectations in cases with obsessional rituals
1966 • 376 citations
Quality of life for patients with obsessive-compulsive disorder
1996 • 369 citations
Glucocorticoids as a biological substrate of reward: physiological and pathophysiological implications
1997 • 369 citations
Decrease in Caudate Glutamatergic Concentrations in Pediatric Obsessive-Compulsive Disorder Patients Taking Paroxetine
2000 • 368 citations
Cognitive-behavioral body image therapy for body dysmorphic disorder.
1995 • 367 citations
Body dysmorphic disorder: A cognitive behavioural model and pilot randomised controlled trial
1996 • 364 citations
Localized Orbitofrontal and Subcortical Metabolic Changes and Predictors of Response to Paroxetine Treatment in Obsessive-Compulsive Disorder
1999 • 361 citations
Compulsions, Parkinson's disease, and stimulation
2002 • 359 citations
Clomipramine in the Treatment of Patients With Obsessive-Compulsive Disorder
1991 • 352 citations
Prospective Long-Term Follow-Up of 44 Patients Who Received Cingulotomy for Treatment-Refractory Obsessive-Compulsive Disorder
2002 • 350 citations
Delay Activity of Orbital and Lateral Prefrontal Neurons of the Monkey Varying with Different Rewards
2000 • 348 citations
Basal ganglia dysfunction in Tourette’s syndrome: a new hypothesis
2001 • 348 citations
Surgical and Nonpsychiatric Medical Treatment of Patients With Body Dysmorphic Disorder
2001 • 339 citations
A Functional Neuroanatomy of Tics in Tourette Syndrome
2000 • 334 citations
Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.
1994 • 332 citations
Obsessive compulsive spectrum disorder.
1994 • 326 citations
Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive- compulsive children
1992 • 325 citations
Obsessive-compulsive disorder: theory, research, and treatment
1998 • 322 citations
Input-output organization of the sensorimotor striatum in the squirrel monkey
1994 • 321 citations
[18F]FDG PET Study in Obsessive–Compulsive Disorder
1995 • 319 citations
The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction
1999 • 318 citations
Treatment of psychiatric illness by stereotactic cingulotomy
1987 • 314 citations
Event‐related brain potentials and error‐related processing: An analysis of incorrect responses to go and no‐go stimuli
1996 • 313 citations
Symptom structure in obsessive-compulsive disorder: a confirmatory factor-analytic study
1999 • 313 citations
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder
1997 • 311 citations
Cognitive Deficits in Obsessive–Compulsive Disorder on Tests of Frontal–Striatal Function
1998 • 308 citations
A Randomized Placebo-Controlled Trial of Fluoxetine in Body Dysmorphic Disorder
2002 • 304 citations
Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issues
2003 • 304 citations
fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder
2000 • 304 citations
Childhood obsessive-compulsive disorder
1981 • 300 citations
Deep brain stimulation for treatment‐refractory obsessive‐compulsive disorder: psychopathological and neuropsychological outcome in three cases
2003 • 298 citations
MRI Assessment of Children With Obsessive-Compulsive Disorder or Tics Associated With Streptococcal Infection
2000 • 298 citations
Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning
1997 • 296 citations
Anterior cingulate activity during routine and non-routine sequential behaviors in macaques
2000 • 292 citations
A randomized double-blind fluvoxamine/placebo crossover trial in pathologic gambling
2000 • 290 citations
Treatment of Chronic Obsessive-Compulsive Neurosis by in-vivo Exposure
1975 • 289 citations
The limbic system: an anatomic, phylogenetic, and clinical perspective
1997 • 285 citations
FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder
1998 • 284 citations
Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder
1984 • 283 citations
The Prefrontal Cortex
1999 • 278 citations
Obsessive‐compulsive disorder: a clinical, neuropsychological and positron emission tomography study
1990 • 278 citations
Psychiatric Disorders in First Degree Relatives of Children and Adolescents with Obsessive Compulsive Disorder
1990 • 271 citations
Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder
1999 • 270 citations
Symptom Stability in Adult Obsessive-Compulsive Disorder: Data From a Naturalistic Two-Year Follow-Up Study
2002 • 268 citations
A Placebo-Controlled Trial of Cognitive-Behavioral Therapy and Clomipramine in Trichotillomania
2000 • 265 citations
Functional Anatomy of Spatial Mental Imagery Generated from Verbal Instructions
1996 • 264 citations
Epidemiology of obsessive compulsive disorder.
1990 • 264 citations
Serotonergic Function in Obsessive-Compulsive Disorder
1992 • 263 citations
Neuropyschological performance in obsessive-compulsive disorder
1992 • 259 citations
Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Striatum
1998 • 258 citations
Cingulotomy for Refractory Obsessive Compulsive Disorder
1991 • 258 citations
Clomipramine vs Desipramine Crossover Trial in Body Dysmorphic Disorder
1999 • 257 citations
Influence of Expectation of Different Rewards on Behavior-Related Neuronal Activity in the Striatum
2001 • 256 citations
Long-Term Follow-Up and Predictors of Clinical Outcome in Obsessive-Compulsive Patients Treated With Serotonin Reuptake Inhibitors and Behavioral Therapy
2001 • 246 citations
Epidemiology of obsessive-compulsive disorder: a world view.
1997 • 234 citations
Clomipramine, Self-exposure and Therapist-aided Exposure for Obsessive–Compulsive Rituals
1988 • 232 citations
Psychiatric Comorbidity in Pathological Gamblers Seeking Treatment
2001 • 231 citations
Deficit in cognitive shifting ability in patients with obsessive-compulsive disorder
1989 • 223 citations
Context in the clinic: how well do cognitive-behavioral therapies and medications work in combination?
2002 • 221 citations
Clinical Predictors of Drug Response in Obsessive-Compulsive Disorder
2001 • 221 citations
Clinical profile, comorbidity, and treatment history in 123 hair pullers: a survey study.
1995 • 220 citations
Medication therapy for social phobia.
1994 • 220 citations
Stepping out of the box: information processing in the neural networks of the basal ganglia
2001 • 216 citations
Regional Xenon 133 Cerebral Blood Flow and Cerebral Technetium 99m HMPAO Uptake in Unmedicated Patients With Obsessive-Compulsive Disorder and Matched Normal Control Subjects
1992 • 215 citations
Corticostriatal projections from the somatic motor areas of the frontal cortex in the macaque monkey: segregation versus overlap of input zones from the primary motor cortex, the supplementary motor area, and the premotor cortex
1998 • 214 citations
Antibodies against human putamen in children with Tourette syndrome
1998 • 214 citations
Pathological gambling and major affective disorder: preliminary findings.
1986 • 210 citations
Controlled trial of exposure and response prevention in obsessive–compulsive disorder
1997 • 210 citations
Neurobiology of the obsessive–compulsive spectrum disorders
2000 • 207 citations
Hypochondriasis
1986 • 205 citations
Differential Cerebral Metabolic Changes With Paroxetine Treatment of Obsessive-Compulsive Disorder vs Major Depression
2002 • 205 citations
Obsessive-Compulsive Disorders: Theory and Management
1986 • 205 citations
Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI
1998 • 202 citations
B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?
1997 • 200 citations
Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently
2001 • 200 citations
Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study
1991 • 200 citations
Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive–compulsive disorder
2003 • 199 citations
Neuropsychological deficits in obsessive-compulsive disorder
1991 • 198 citations
Obsessive-compulsive disorder in the community: an epidemiologic survey with clinical reappraisal
1997 • 194 citations
Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
1999 • 192 citations
Psychiatric Comorbidity in DSM-III-R Hypochondriasis
1992 • 191 citations
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
2000 • 189 citations
The DSM-III-R impulse control disorders not elsewhere classified: clinical characteristics and relationship to other psychiatric disorders
1992 • 188 citations
Introduction: Obsessive-compulsive spectrum disorders
1995 • 185 citations
Predictors of drug treatment response in obsessive-compulsive disorder.
1995 • 183 citations
Body dysmorphic disorder: an obsessive-compulsive spectrum disorder, a form of affective spectrum disorder, or both?
1995 • 182 citations
Motor and Cognitive Functions of the Prefrontal Cortex
1994 • 182 citations
Efficacy and Safety of Fluvoxamine in Body Dysmorphic Disorder
1998 • 182 citations
Combination of behaviour therapy with fluvoxamine in comparison with behaviour therapy and placebo. Results of a multicentre study.
1998 • 178 citations
A Handbook of Neuropsychological Assessment
2018 • 178 citations
The epidemiology of obsessive compulsive disorder.
1984 • 177 citations
Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Orbitofrontal Cortex
2000 • 176 citations
The Epidemiology of Tourette's Syndrome: A Pilot Study
1982 • 172 citations
Combination of behaviour therapy with fluvoxamine in comparison with behaviour therapy and placebo
1998 • 170 citations
Risperidone Augmentation of Serotonin Reuptake Inhibitors in Obsessive-Compulsive and Related Disorders
1997 • 169 citations
Neuropsychological and power spectral EEG investigations of the obsessive-compulsive syndrome.
1979 • 168 citations
A Further Review of the Results of Stereotactic Subcaudate Tractotomy
1975 • 167 citations
Predictors of Fluvoxamine Response in Contamination-related Obsessive Compulsive Disorder A PET Symptom Provocation Study
2002 • 167 citations
A Short Echo1H Spectroscopy and Volumetric MRI Study of the Corpus Striatum in Patients With Obsessive- Compulsive Disorder and Comparison Subjects
1998 • 167 citations
Neurological and neuropsychological studies of patients with obsessive-compulsive disorder.
1983 • 166 citations
Predictors of course in obsessive compulsive disorder
1999 • 166 citations
Amygdalectomy and ventromedial prefrontal ablation produce similar deficits in food choice and in simple object discrimination learning for an unseen reward
1991 • 165 citations
A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)
2000 • 162 citations
The metabolic anatomy of Tourette's syndrome
1997 • 161 citations
Treatment of body-dysmorphic disorder with serotonin reuptake blockers
1989 • 158 citations
Body dysmorphic disorder, pathological gambling, and sexual compulsions.
1995 • 154 citations
1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum
1997 • 154 citations
Risperidone augmentation of SRI treatment for refractory obsessive-compulsive disorder.
1996 • 154 citations
Behavior and the basal ganglia.
1995 • 154 citations
Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers
2003 • 152 citations
Stereotactic Limbic Leucotomy—A Follow-up at 16 Months
1976 • 152 citations
Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorder
2001 • 152 citations
Obsessive compulsive spectrum disorders.
1994 • 150 citations
The characterization and treatment of trichotillomania.
1996 • 146 citations
Obsessive and compulsive symptoms in a general population sample of female twins
2000 • 142 citations
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
2001 • 140 citations
Body dysmorphic disorder in the DSM-IV field trial for obsessive- compulsive disorder
1995 • 140 citations
An Open-Label Study of Citalopram in Body Dysmorphic Disorder
2003 • 140 citations
Comparison of obsessive-compulsive disorder patients with and without comorbid putative obsessive-compulsive spectrum disorders using a structured clinical interview
2001 • 138 citations
Neurosurgical treatment for refractory obsessive-compulsive disorder: implications for understanding frontal lobe function
1994 • 134 citations
Neurosurgical treatment of obsessive-compulsive disorder
1998 • 134 citations
Ein Beitrag zur Frage der Zwangskrankheit, insbesondere ihrer heredit�ren Beziehungen
1953 • 133 citations
Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics
1997 • 133 citations
Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases.
1995 • 131 citations
Tonically active neurons in the primate striatum and their role in the processing of information about motivationally relevant events
2002 • 131 citations
Bi-Frontal Stereotactic Tractotomy
1971 • 129 citations
Alteration of Serotonin Release in the Guinea Pig Orbito-Frontal Cortex by Selective Serotonin Reuptake Inhibitors Relevance to Treatment of Obsessive-Compulsive Disorder
1995 • 129 citations
Obsessive compulsive disorder and basal ganglia dysfunction
1990 • 129 citations
Wisconsin Card Sorting Task (WCST) errors and cerebral blood flow in obsessive‐compulsive disorder (OCD)
1997 • 125 citations
Association between the COMT locus and obsessive‐compulsive disorder in females but not males
2001 • 125 citations
Multicenter Double-blind Comparison of Sertraline and Desipramine for Concurrent Obsessive-Compulsive and Major Depressive Disorders
2000 • 125 citations
Body Dysmorphic Disorder
2000 • 124 citations
Dopamine antagonists in tic-related and psychotic spectrum obsessive compulsive disorder.
1994 • 123 citations
Regional Cerebral Glucose Metabolism of Women With Trichotillomania
1991 • 122 citations
Anxiety and Cerebral Blood Flow During Behavioral Challenge
1989 • 122 citations
Functional significance of mesolimbic dopamine
1995 • 121 citations
Low-dose pimozide augmentation of serotonin reuptake blockers in the treatment of trichotillomania
1992 • 121 citations
Body dysmorphic disorder in a sample of cosmetic surgery applicants
2003 • 120 citations
Effects of fluoxetine on regional cerebral blood flow in obsessive- compulsive patients
1991 • 119 citations
Tourette's Syndrome
2000 • 119 citations
Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways
2000 • 118 citations
Pharmacotherapy of Obsessive-Compulsive Disorder
1992 • 116 citations
Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive–compulsive disorder∗
2000 • 115 citations
Neuroanatomical aspects of cognitive-behavioural therapy response in obsessive-compulsive disorder
1998 • 113 citations
The caudate nucleus in obsessive–compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study
2002 • 112 citations
Reward Unpredictability inside and outside of a Task Context as a Determinant of the Responses of Tonically Active Neurons in the Monkey Striatum
2001 • 110 citations
Bimedial Leucotomy in Obsessive-Compulsive Neurosis: A Controlled Serial Enquiry
1971 • 110 citations
Neurobiology of Obsessive Compulsive Disorder
1992 • 108 citations
Behavior Therapy for Obsessive Compulsive Disorder
1992 • 108 citations
Elevated thalamic and prefrontal regional cerebral blood flow in obsessive–compulsive disorder: a SPECT study
2003 • 106 citations
Investigation of dopamine system genes in obsessive-compulsive disorder
1998 • 105 citations
The relationship of obsessive-compulsive disorder to putative spectrum disorders: results from an Indian study
2003 • 105 citations
Cognitive-Behavioral Therapy as an Adjunct to Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder
1999 • 104 citations
Outcome after the psychosurgical operation of stereotactic subcaudate tractotomy, 1979-1991
1995 • 104 citations
Is the 5-HT1DβReceptor Gene Implicated in the Pathogenesis of Obsessive-Compulsive Disorder?
2000 • 103 citations
Functional brain imaging and pharmacotherapy in social phobia: Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram
2000 • 102 citations
Pregnancy and Obsessive-Compulsive Disorder
1993 • 101 citations
Basal ganglia role in behavior: importance of sensory gating and its relevance to psychiatry.
1984 • 101 citations
Body dysmorphic disorder: a preliminary evaluation of treatment and maintenance using exposure with response prevention
1997 • 99 citations
Neuropsychological performance and regional cerebral blood flow in obsessive–compulsive disorder
2003 • 99 citations
Role of Tonically Active Neurons in Primate Caudate in Reward-Oriented Saccadic Eye Movement
2001 • 98 citations
Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression
2001 • 98 citations
Stereotactic Limbic Leucotomy: A Preliminary Report on Forty Patients
1973 • 98 citations
Neurosurgical Treatment of Malignant Obsessive Compulsive Disorder
1992 • 97 citations
Normal and Abnormal Information Processing: A Neuropsychological Perspective on Obsessive Compulsive Disorder
1992 • 96 citations
Network models of the basal ganglia
1997 • 94 citations
Obsessive-compulsive disorder: diagnosis and treatment.
1999 • 94 citations
Olanzapine and the new generation of antipsychotic agents: patterns of use.
1997 • 92 citations
Body dysmorphic disorder in patients with anxiety disorders and major depression: a comorbidity study
1995 • 92 citations
Regional 133Xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment
1995 • 89 citations
No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive–compulsive disorder, anorexia nervosa, and alcoholism
1999 • 89 citations
Association between the dopamine receptor D4 (DRD4) gene and obsessive‐compulsive disorder
2002 • 88 citations
Case Study: Caudate Glutamatergic Changes With Paroxetine Therapy for Pediatric Obsessive‐Compulsive Disorder
1998 • 86 citations
Single neuron responses in the monkey anterior cingulate cortex during visual discrimination
1997 • 86 citations
Psychiatric Comorbidity in Pathological Gamblers Seeking Treatment
2001 • 86 citations
Episodic and chronic obsessive-compulsive disorder
1997 • 84 citations
Modern Neurosurgery for Psychiatric Disorders
2000 • 83 citations
Diagnostic issues and epidemiology in obsessive–compulsive disorder.
1998 • 82 citations
DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder.
1996 • 82 citations
Additional evidence that genetic variation of MAO‐A gene supports a gender subtype in obsessive‐compulsive disorder
2001 • 80 citations
The Pharmacotherapy of Obsessive-Compulsive Disorder
1993 • 79 citations
Comparison of neuronal activity in the rostral supplementary and cingulate motor areas during a task with cognitive and motor demands
2002 • 79 citations
A role for volition and attention in the generation of new brain circuitry. Toward a neurobiology of mental force
1999 • 78 citations
Computational models of the basal ganglia
2000 • 71 citations
Hypochondriasis and obsessive compulsive disorder: overlaps in diagnosis and treatment.
1991 • 69 citations
Functional magnetic resonance imaging study of frontal lobe activation during word generation in obsessive–compulsive disorder
1999 • 69 citations
Association between homozygosity at the COMT gene locus and obsessive compulsive disorder
2000 • 69 citations
Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive–compulsive disorder
1999 • 68 citations
Childhood movement disorders and obsessive compulsive disorder.
1994 • 68 citations
Influence of the predicted time of stimuli eliciting movements on responses of tonically active neurons in the monkey striatum
2000 • 65 citations
The Patient with Hypochondriasis
2001 • 64 citations
Comorbid social anxiety and body dysmorphic disorder: managing the complicated patient.
1999 • 63 citations
Influence of Predictive Information on Responses of Tonically Active Neurons in the Monkey Striatum
1998 • 62 citations
A Comparative Review of Patients with Obsessional Neurosis and with Depression Treated by Psychosurgery
1973 • 61 citations
Influence of Spatial Information on Responses of Tonically Active Neurons in the Monkey Striatum
2006 • 61 citations
Neurochemical Analyses in Pediatric Obsessive-Compulsive Disorder in Patients Treated With Cognitive-Behavioral Therapy
2003 • 58 citations
The potential role of haloperidol in the treatment of trichotillomania
1999 • 56 citations
The pharmacotherapy of hypochondriasis.
1996 • 56 citations
Psychosocial treatments for obsessive–compulsive disorder: Literature review.
1998 • 56 citations
Increased cerebral blood flow during m-CPP exacerbation of obsessive- compulsive disorder
1995 • 56 citations
Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders
2001 • 55 citations
Functional organization of the circuits connecting the cerebral cortex and the basal ganglia: implications for the role of the basal ganglia in epilepsy
2002 • 54 citations
Novel physical treatments for the management of neuropsychiatric disorders
2002 • 53 citations
5HT2C CYS23/SER23 polymorphism is not associated with obsessive–compulsive disorder
1998 • 52 citations
Lack of evidence for huntington's disease-like cognitive dysfunction in obsessive-compulsive disorder
1993 • 52 citations
Is obsessive-compulsive disorder an autoimmune disease?
2001 • 51 citations
Increased Medial Thalamic Choline in Pediatric Obsessive-Compulsive Disorder as Detected by Quantitative in Vivo Spectroscopic Imaging
2001 • 51 citations
Body Dysmorphic Disorder Diagnostic Issues and Related Disorders
1992 • 51 citations
Cognitive risk-taking after frontal or temporal lobectomy—I. The synthesis of fragmented visual information
1985 • 50 citations
NEUROANATOMICALLY BASED APPROACHES TO OBSESSIVE-COMPULSIVE DISORDER
2000 • 49 citations
Stereotactic limbic leucotomy—a follow-up study of thirty patients
1973 • 49 citations
Fluvoxamine in the treatment of obsessive-compulsive disorder and related conditions.
1997 • 48 citations
Body Dysmorphic Disorder
2002 • 48 citations
Context Dependency in the Globus Pallidus Internal Segment During Targeted Arm Movements
2001 • 47 citations
Neuropsychiatry and SPECT of an Acute Obsessive–Compulsive Syndrome Patient
1995 • 47 citations
A Family Study of Hypochondriasis
1997 • 46 citations
Recent findings in the genetics of OCD.
2002 • 45 citations
Considerations of natural history and pathophysiology in the psychopharmacology of Tourette's syndrome.
1996 • 43 citations
Functional brain imaging and pharmacotherapy in trichotillomania Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram
2002 • 41 citations
Effects of meta-chlorophenylpiperazine on cerebral blood flow in obsessive–compulsive disorder and controls
1998 • 39 citations
Neurobiology of obsessive compulsive disorder
1992 • 34 citations
The action of chlorimipramine in obsessive-compulsive neurosis: a pilot study.
1975 • 33 citations
A Possible Poststreptococcal Movement Disorder with Chorea and Tics
1990 • 32 citations
Clomipramine: plasma levels, side effects and outcome in obsessive-compulsive neurosis.
1980 • 28 citations
BODY DYSMORPHIC DISORDER
2000 • 27 citations
The relationship of plasma clomipramine and N-desmethylclomipramine to response in obsessive-compulsive disorder.
1990 • 24 citations
Drug therapy and cerebral perfusion in obsessive-compulsive disorder.
1995 • 22 citations
Evaluation of the safety and efficacy of quazepam for the treatment of insomnia in psychiatric outpatients.
1994 • 21 citations
Using Locations to Store Shape: An Indirect Effect of a Lesion
1993 • 19 citations
Behavior therapy for obsessive compulsive disorder.
1994 • 16 citations
How to Study Frontal Lobe Functions in Humans
1994 • 11 citations
The functional anatomy of logic: A PET study of inferential reasoning
1996 • 8 citations
Deleted Work
1955 • 0 citations