Ciliary Neuronotrophic Factor

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

Laminin promotes neuritic regeneration from cultured peripheral and central neurons.

1983 • 726 citations

Glial Cell Diversification in the Rat Optic Nerve

1989 • 725 citations

Cell death in the development of the lateral motor column of the chick embryo

1975 • 658 citations

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1988 • 657 citations

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1989 • 624 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor

1989 • 557 citations

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

1988 • 539 citations

Purification of the Chick Eye Ciliary Neuronotrophic Factor

1984 • 519 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site

1982 • 477 citations

Neuropoietic cytokines in the hematopoietic fold

1991 • 474 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Possible roles for cell-to-substratum adhesion in neuronal morphogenesis

1975 • 441 citations

Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)

1989 • 429 citations

Cholinergic Neuronotrophic Factors: Intraocular Distribution of Trophic Activity for Ciliary Neurons

1979 • 414 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity

1983 • 389 citations

Naturally Occurring Neuronal Death in Vertebrates

1990 • 389 citations

Nerve growth factor induces growth and differentiation of human B lymphocytes.

1989 • 386 citations

Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor

1985 • 384 citations

NEURONAL DEATH AS A REGULATIVE MECHANISM IN THE CONTROL OF CELL NUMBER IN THE NERVOUS SYSTEM

1973 • 364 citations

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

1988 • 356 citations

Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture.

1989 • 347 citations

Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain.

1991 • 346 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

Naturally Occurring Neuron Death and Its Regulation by Developing Neural Pathways

1982 • 306 citations

Proliferation and differentiation of embryonic chick sympathetic neurons: Effects of ciliary neurotrophic factor

1989 • 297 citations

PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.

1986 • 282 citations

Synthesis and secretion of nerve growth factor by mouse astroglial cells in culture

1986 • 278 citations

Neurotrophic molecules

1989 • 270 citations

Differentiation of a bipotential glial progenitor cell in single cell microculture

1985 • 262 citations

Purification of adult rat sciatic nerve ciliary neuronotrophic factor

1986 • 253 citations

The onset and development of transmission in the chick ciliary ganglion

1972 • 252 citations

Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes

1988 • 249 citations

Induction of neurite outgrowth by a conditioned-medium factor bound to the culture substratum

1978 • 245 citations

Synapse formation during embryogenesis on ganglion cells lacking a periphery

1974 • 235 citations

Role of extracellular matrix in the action of basic fibroblast growth factor: Matrix as a source of growth factor for long‐term stimulation of plasminogen activator production and DNA synthesis

1989 • 227 citations

Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers

1983 • 218 citations

Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS

1992 • 213 citations

Multiple influences of a heparin-binding growth factor on neuronal development.

1987 • 212 citations

Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.

1988 • 200 citations

G to A substitution in the distal CCAAT box of the Aγ-globin gene in Greek hereditary persistence of fetal haemoglobin

1985 • 198 citations

Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons

1989 • 197 citations

Trophic and Specifying Factors Directed to Neuronal Cells

1981 • 186 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures.

1991 • 182 citations

Characterization of two ganglion cell populations in avian ciliary ganglia

1971 • 181 citations

Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia

1976 • 178 citations

Immunolocalization of ciliary neuronotrophic factor in adult rat sciatic nerve

1992 • 167 citations

Mediators in cell growth and differentiation.

1984 • 166 citations

Rat astrocytes and Schwann cells in culture synthesize nerve growth factor-like neurite-promoting factors

1987 • 165 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

1991 • 164 citations

Cholinergic neuronotrophic factors: I. Survival, neurite outgrowth and choline acetyltransferase activity in monolayer cultures from chick embryo ciliary ganglia

1979 • 160 citations

chapter 6 Nerve Growth Factors and Control of Nerve Growth

1980 • 158 citations

Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neurons

1992 • 155 citations

Extracellular matrix-associated molecules collaborate with ciliary neurotrophic factor to induce type-2 astrocyte development.

1990 • 155 citations

Axon initiation by ciliary neurons in culture

1978 • 154 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

Novel Neurotrophic Factors, Receptors, and Oncogenes

1989 • 152 citations

Development and aging in the nervous system

1974 • 152 citations

Interactions between neurons and their targets during in vivo synaptogenesis.

1978 • 152 citations

The output of neuronotrophic and neurite-promoting agents from rat brain astroglial cells: a microculture method for screening potential regulatory molecules

1985 • 148 citations

Dissociated ciliary ganglion neurons in vitro: survival and synapse formation.

1977 • 147 citations

Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned medium

1977 • 141 citations

Differentiation signals in the CNS: Type-2 astrocyte development in vitro as a model system

1990 • 139 citations

Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers

1983 • 136 citations

Cholinergic Neuronotrophic Factors: Fractionation Properties of an Extract from Selected Chick Embryonic Eye Tissues

1980 • 133 citations

Survival and development of ciliary ganglion neurones grown alone in cell culture

1979 • 128 citations

DEVELOPMENTAL CHANGES IN THE STRUCTURE OF THE SYNAPSE ON THE MYELINATED CELL BODIES OF THE CHICKEN CILIARY GANGLION

1965 • 127 citations

Neuronotrophic and Neurite-Promoting Factors and Their Clinical Potentials pp. 73–86

1983 • 118 citations

Effects of high K+ concentrations on the growth and development of ciliary ganglion neurons in cell culture

1981 • 116 citations

ASTROGLIAL CELL CONTRIBUTIONS TO NEURONAL SURVIVAL AND NEURITIC GROWTH

1986 • 114 citations

Neurite‐Promoting Factor in Conditioned Medium from RN22 Schwannoma Cultures: Bioassay, Fractionation, and Properties

1982 • 112 citations

Cholinergic neuronotrophic factors: V. Segregation of survival- and neurite-promoting activities in heart-conditioned media

1980 • 112 citations

Purification and characterization of a trophic factor for embryonic peripheral neurons: Comparison with fibroblast growth factors

1990 • 111 citations

Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons

1990 • 108 citations

Neurotrophic Factors and Neuronal Death

2007 • 106 citations

NGF Amplifies Expression of NGF Receptor Messenger RNA in Forebrain Cholinergic Neurons of Rats

1989 • 97 citations

Recombinant Human and Rat Ciliary Neurotrophic Factors

1991 • 96 citations

Cytokines and neurokines: related ligands and related receptors

1992 • 95 citations

Substratum-binding neurite-promoting factors: relationships to laminin

1985 • 93 citations

Cholinergic neuronotrophic factors

1980 • 93 citations

Ciliary neurotrophic factor supports target-deprived preganglionic sympathetic spinal cord neurons

1989 • 85 citations

Effects of ciliary neuronotrophic factor on rat spinal cord neurons in vitro: survival and expression of choline acetyltransferase and low-affinity nerve growth factor receptors

1991 • 84 citations

Fast and slow nerve growth factor binding sites in human neuroblastoma and rat pheochromocytoma cell lines: relationship of sites to each other and to neurite formation

1985 • 84 citations

Rescue of motoneurons from cell death by a purified skeletal muscle polypeptide: Effects of the ChAT development factor, CDF

1990 • 83 citations

Solubilization of a membrane factor that stimulates levels of substance P and choline acetyltransferase in sympathetic neurons.

1987 • 79 citations

Characterization of two factors enhancing choline acetyltransferase activity in cultures of purified rat motoneurons

1989 • 76 citations

Purification of a skeletal muscle polypeptide which stimulates choline acetyltransferase activity in cultured spinal cord neurons.

1988 • 75 citations

Survival of purified embryonic chick retinal ganglion cells in the presence of neurotrophic factors

1989 • 73 citations

Nerve growth factor effects on cholinergic neurons of neostriatum and nucleus accumbens in the adult rat

1989 • 71 citations

Neuronal adjustments in developing nuclear centers of the chick embryo following transplantation of an additional optic primordium

1978 • 70 citations

Axotomy-dependent stimulation of choline acetyltransferase activity by exogenous mouse nerve growth factor in adult rat basal forebrain

1989 • 67 citations

High ciliary neuronotrophic specific activity in rat peripheral nerve

1984 • 67 citations

Basic fibroblast growth factor is a substrate for protein phosphorylation and is phosphorylated by capillary endothelial cells in culture.

1989 • 65 citations

An inducer protein may control the timing of fate switching in a bipotential glial progenitor cell in rat optic nerve

1987 • 65 citations

Growth factors in biology and medicine

1986 • 64 citations

Sequence and structural organization of the human gene encoding ciliary neurotrophic factor

1991 • 63 citations

Neuronotrophic and neurite-promoting factors: Effects on early postnatal chromaffin cells from rat adrenal medulla

1985 • 62 citations

Multiple Neurotrophic Factors from Skeletal Muscle: Demonstration of Effects of Basic Fibroblast Growth Factor and Comparisons with the 22‐Kilodalton Choline Acetyltransferase Development Factor

1989 • 61 citations

The cholinergic neuronal differentiation factor from heart cell conditioned medium is different from the cholinergic factors in sciatic nerve and spinal cord

1990 • 61 citations

Phosphorylation of intracellular precursors of human IL-1.

1988 • 57 citations

Development of cholinergic pedunculopontine neurons in vitro: Comparison with Cholinergic septal cells and response to nerve growth factor, ciliary neuronotrophic factor, and retinoic acid

1988 • 57 citations

Developmental changes in the responses of rat chromaffin cells to neuronotrophic and neurite-promoting factors

1985 • 55 citations

Ciliary Neuronotrophic Factor Stimulates Choline Acetyltransferase Activity in Cultured Chicken Retina Neurons

1988 • 54 citations

Isolation and characterization of ciliary neurotrophic factor from rabbit sciatic nerves.

1990 • 52 citations

The precursor of interleukin-1 alpha is phosphorylated at residue serine 90.

1988 • 50 citations

Purification of a Ciliary Neurotrophic Factor from Bovine Heart

1987 • 50 citations

Partial purification and characterization of a membrane-derived factor regulating neurotransmitter phenotypic expression.

1989 • 49 citations

Localized survival of ciliary ganglionic neurons identifies neuronotrophic factor bands on nitrocellulose blots

1985 • 48 citations

The innervation of chick striated muscle fibers by the chick ciliary ganglion in tissue culture

1975 • 47 citations

Identification of basic fibroblast growth factor as a cholinergic growth factor from human muscle

1989 • 43 citations

Characterization of tissue-derived macromolecules affecting transmitter synthesis in rat spinal cord neurons

1985 • 41 citations

Biological activities of nerve growth factor bound to nitrocellulose paper by Western blotting

1988 • 41 citations

The formation of synapses between chick embryo skeletal muscle and ciliary ganglia grown in vitro.

1976 • 39 citations

An examination of ciliary neuronotrophic factors from avian and rodent tissue extracts using a blot and culture technique

1987 • 38 citations

Effect of CNTF on low‐affinity NGF receptor expression by cultured neurons from different rat brain regions

1991 • 38 citations

Characterization of Chick Gizzard Extract That Promotes Neurite Outgrowth in Cultured Ciliary Neurons

1982 • 37 citations

Synthesis, purification, and characterization of human ciliary neuronotrophic factor from E. coli

1991 • 37 citations

Distribution of fibroblast growth factors (FGFs) in tissues and structure-function studies with synthetic fragments of basic FGF

1987 • 34 citations

Rat sciatic nerve schwann cell microcultures: Responses to mitogens and production of trophic and neurite-promoting factors

1989 • 33 citations

Nerve growth factor receptor in neural lobe of rat pituitary gland: immunohistochemical localization, biochemical characterization and regulation

1990 • 32 citations

Nerve Growth Factor

1985 • 32 citations

Cholinergic neuronotrophic factors

1981 • 31 citations

Development and regeneration in the central nervous system

1990 • 28 citations

Medial-to-lateral gradient of neostriatal NGF receptors: relationship to cholinergic neurons and NGF-like immunoreactivity

1991 • 27 citations

Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli

1991 • 27 citations

Differential Effects of Nerve Growth Factor and Ciliary Neuronotrophic Factor on Catecholamine Storage and Catecholamine Synthesizing Enzymes of Cultured Rat Chromaffin Cells

1987 • 23 citations

Neuronal survival in intact ciliary ganglia in vivo and in vitro: Ciliary neuronotrophic factor as a target surrogate

1982 • 21 citations

CNTF rescues motoneurons from ontogenetic cell death in-vivo, but not in-vitro

1990 • 21 citations

Expression of growth factor receptors in injured nervous tissue. II. Induction of specific platelet-derived growth factor binding in the injured PNS is associated with a breakdown in the blood-nerve barrier and endoneurial interstitial oedema

1987 • 20 citations

The Journey of a Neuroembryologist

1989 • 19 citations

Isoelectric focusing of the chick eye ciliary neuronotrophic factor

1982 • 19 citations

Neuronotrophic factors: effects on central cholinergic regeneration in vivo

1985 • 19 citations

A monoclonal antibody to a parasympathetic neurotrophic factor causes immunoparasympathectomy in mice

1988 • 16 citations

Survival, morphology, and catecholamine storage of chromaffin cells in serum-free culture: Evidence for a survival and differentiation promoting activity in medium conditioned by purified chromaffin cells

1987 • 15 citations

Studies on the release of cell‐associated interleukin 1 by paraformaldehyde‐treated murine macrophages

1988 • 15 citations

Control of Na+,K+-pump activity in dorsal root ganglionic neurons by different neuronotrophic agents

1986 • 14 citations

Role of Nerve Growth Factor in Neuronal Injury and Survival

1988 • 12 citations

Monoclonal antibody that inhibits biological activity of a mammalian ciliary neurotrophic factor

1989 • 10 citations

Partial purification of a parasympathetic neurotrophic factor in pig lung

1987 • 8 citations

Neural Development and Regeneration: Cellular and Molecular Aspects

1989 • 6 citations

Nerve growth factor: mechanism of action.

1984 • 6 citations

Deleted Work

1955 • 0 citations