Immunoediting of Cancers May Lead to Epithelial to Mesenchymal Transition

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Molecular requirements for epithelial–mesenchymal transition during tumor progression

2005 • 1,799 citations

Epithelial–mesenchymal transitions in development and pathologies

2003 • 1,700 citations

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

2005 • 1,613 citations

An Overview of Epithelio-Mesenchymal Transformation

1995 • 1,505 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Adoptive T cell therapy using antigen-specific CD8⁺T cell clones for the treatment of patients with metastatic melanoma:In vivopersistence, migration, and antitumor effect of transferred T cells

2002 • 1,187 citations

Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways

2005 • 1,177 citations

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

2004 • 888 citations

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

2004 • 801 citations

Epithelial to Mesenchymal Transition Is a Determinant of Sensitivity of Non–Small-Cell Lung Carcinoma Cell Lines and Xenografts to Epidermal Growth Factor Receptor Inhibition

2005 • 634 citations

Context, tissue plasticity, and cancer

2005 • 470 citations

Recruitment of latent pools of high-avidity CD8+ T cells to the antitumor immune response

2005 • 403 citations

Tumor Necrosis Factor-α Stimulates the Epithelial-to-Mesenchymal Transition of Human Colonic Organoids

2003 • 326 citations

CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells

2005 • 308 citations

Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis

2003 • 300 citations

Matrix Metalloproteinases as Therapeutic Targets in Cancer

2005 • 279 citations

Context, tissue plasticity, and cancerAre tumor stem cells also regulated by the microenvironment?

2005 • 248 citations

Host microenvironment in breast cancer development: Epithelial–mesenchymal transition in breast cancer development

2003 • 223 citations

HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice.

2000 • 219 citations

Identification of Multiple Antigens Recognized by Tumor-Infiltrating Lymphocytes From a Single Patient: Tumor Escape by Antigen Loss and Loss of MHC Expression

2004 • 209 citations

Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma

1998 • 206 citations

Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer

2005 • 178 citations

The collaboration of both humoral and cellular HER-2/neu-targeted immune responses is required for the complete eradication of HER-2/neu-expressing tumors.

2001 • 157 citations

Total loss of MHC class I is an independent indicator of good prognosis in breast cancer

2005 • 146 citations

IL-2 Immunotoxin Therapy Modulates Tumor-Associated Regulatory T Cells and Leads to Lasting Immune-Mediated Rejection of Breast Cancers in neu-Transgenic Mice

2006 • 132 citations

Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo.

1988 • 127 citations

Reciprocal Changes in Tumor Antigenicity and Antigen-specific T Cell Function during Tumor Progression

2004 • 102 citations

Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-Transgenic Mice

2003 • 100 citations

Potent Selection of Antigen Loss Variants of B16 Melanoma following Inflammatory Killing of MelanocytesIn vivo

2005 • 90 citations

Regulating the immune system: the induction of regulatory T cells in the periphery.

2004 • 85 citations

Tumor necrosis factor in solid tumors: increased blood levels in the metastatic disease.

1992 • 80 citations

neu Antigen-Negative Variants Can Be Generated after neu-Specific Antibody Therapy in neu Transgenic Mice

2004 • 70 citations

Adoptive transfer of an anti‐MART‐1_27–35‐specific CD8⁺ T cell clone leads to immunoselection of human melanoma antigen‐loss variants in SCID mice

2003 • 49 citations

IL-12 enhances the generation of tumour antigen-specific Th1 CD4 T cells during ex vivo expansion

2004 • 36 citations

Expansion of HER2/neu-Specific T Cells Ex Vivo Following Immunization with a HER2/neu Peptide-Based Vaccine

2001 • 32 citations

Emergence of immune escape variant of mammary tumors that has distinct proteomic profile and a reduced ability to induce “danger signals”

2005 • 27 citations