Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

The heterogeneity of protein kinase C in various rat tissues

1988 • 208 citations

Expression of four protein kinase C isoforms in rat fibroblasts. Distinct subcellular distribution and regulation by calcium and phorbol esters.

1992 • 160 citations

Characterization of phorbol ester receptors and their down-modulation in GH4C1 rat pituitary cells.

1981 • 142 citations

Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes.

1992 • 115 citations

Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells

1989 • 106 citations

Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.

1992 • 104 citations

Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells

1986 • 90 citations

Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.

1992 • 72 citations

Phorbol esters induce both intracellular translocation and down-regulation of protein kinase C in MCF-7 cells

1986 • 56 citations

The antiproliferative effects of staurosporine are not exclusively mediated by inhibition of protein kinase C

1988 • 54 citations

Altered function of protein kinase C and cyclic adenosine monophosphate-dependent protein kinase in a cell line derived from a mouse lung papillary tumor.

1989 • 32 citations

Differentiation of U-937 histiocytic lymphoma cells towards mature neutrophilic granulocytes by dibutyryl cyclic adenosine-3',5'-monophosphate.

1990 • 25 citations

Mechanism of inhibitory action of prostaglandins on the growth of human gastric carcinoma cell line KATO III

1991 • 19 citations

Modulation by staurosporine of phorbol‐ester‐induced effects on growth and protein kinase C localization in a549 human lung‐carcinoma cells

1992 • 18 citations

Differentiation of Dunn osteosarcoma cells in response to dibutyryl cyclic 3?,5?-adenosine monophosphate

1993 • 5 citations

12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells

1992 • 1 citations