Stimulation of Sphingosine-1-phosphate Formation by the P2Y₂Receptor in HL-60 Cells: Ca²⁺Requirement and Implication in Receptor-Mediated Ca²⁺Mobilization, but Not MAP Kinase Activation

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5

1999 • 255 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

Sphingomyelin‐Derived Lipids Differentially Regulate the Extracellular Signal‐Regulated Kinase 2 (ERK‐2) and c‐Jun N‐Terminal Kinase (JNK) Signal Cascades in Airway Smooth Muscle

1996 • 126 citations

Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors

1997 • 111 citations

Molecular diversity of sphingolipid signalling

1997 • 108 citations

G-Protein-coupled receptors in HL-60 human leukemia cells

1996 • 99 citations

Formyl Peptide Receptor Signaling in HL-60 Cells through Sphingosine Kinase

1999 • 99 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ

1999 • 77 citations

Possible Involvement of Cell Surface Receptors in Sphingosine 1-Phosphate-Induced Activation of Extracellular Signal-Regulated Kinase in C6 Glioma Cells

1999 • 74 citations

Role of sphingosine kinase in Ca²⁺ signalling by epidermal growth factor receptor

1999 • 70 citations

A molecular switch changes the signalling pathway used by the FcγRI antibody receptor to mobilise calcium

1998 • 65 citations

The P2U Purinoceptor Obligatorily Engages the Heterotrimeric G Protein G16 to Mobilize Intracellular Ca2+ in Human Erythroleukemia Cells

1997 • 57 citations

A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.

1996 • 44 citations

Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate—caged SPP

1998 • 41 citations

Activation of mitogen‐activated protein kinase is involved in sphingosine 1‐phosphate‐stimulated interleukin‐6 synthesis in osteoblasts

1997 • 40 citations

Sphingosine 1-Phosphate Stimulates Tyrosine Phosphorylation of Crk

1997 • 34 citations

Assessment of the Extracellular and Intracellular Actions of Sphingosine 1-phosphate by Using the p42/p44 Mitogen-Activated Protein Kinase Cascade as a Model

1999 • 30 citations