The Role of Vitamin B12 in Fasting Hyperhomocysteinemia and Its Interaction with the Homozygous C677T Mutation of the Methylenetetrahydrofolate Reductase (MTHFR) Gene

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Homocysteine and Cardiovascular Disease

1998 • 2,177 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Prevalence of cobalamin deficiency in the Framingham elderly population

1994 • 692 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Prospective Study of Coronary Heart Disease Incidence in Relation to Fasting Total Homocysteine, Related Genetic Polymorphisms, and B Vitamins

1998 • 616 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

Low Circulating Folate and Vitamin B ₆ Concentrations

1998 • 560 citations

Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

1996 • 496 citations

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

1988 • 479 citations

Homocysteine and Thrombotic Disease

1997 • 436 citations

Homocysteinemia due to folate deficiency

1987 • 423 citations

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

1996 • 399 citations

Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease

1994 • 386 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Hyperhomocysteinemia, Atherosclerosis and Thrombosis

1999 • 364 citations

Homocyst(e)ine and Risk of Cardiovascular Disease in the Multiple Risk Factor Intervention Trial

1997 • 359 citations

The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

1997 • 277 citations

Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.

1996 • 263 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Plasma Total Homocysteine, B Vitamins, and Risk of Coronary Atherosclerosis

1997 • 247 citations

Prevalence of Moderate Hyperhomocysteinemia in Patients with Early-Onset Venous and Arterial Occlusive Disease

1995 • 235 citations

Correlation of a Common Mutation in the Methylenetetrahydrofolate Reductase Gene With Plasma Homocysteine in Patients With Premature Coronary Artery Disease

1997 • 234 citations

Myocardial Infarction in Young Women in Relation to Plasma Total Homocysteine, Folate, and a Common Variant in the Methylenetetrahydrofolate Reductase Gene

1997 • 233 citations

Thermolabile Methylenetetrahydrofolate Reductase in Coronary Artery Disease

1997 • 230 citations

Common Mutation in Methylenetetrahydrofolate Reductase

1996 • 226 citations

Methylenetetrahydrofolate Reductase C677T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction

1998 • 213 citations

C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations

1998 • 209 citations

Vitamins as Homocysteine-Lowering Agents

1996 • 177 citations

Vitamin Supplementation Reduces Blood Homocysteine Levels

1998 • 165 citations

Thermolabile Methylenetetrahydrofolate Reductase and Factor V Leiden in the Risk of Deep-Vein Thrombosis

1998 • 160 citations

A derangement in B12 metabolism associated with homocystinemia, cystathioninemia, hypomethioninemia and methylmalonic aciduria

1970 • 147 citations

Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations

1992 • 140 citations

The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease

1997 • 139 citations

Homocystinuria with methylmalonic aciduria: Two cases in a sibship

1970 • 137 citations

Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations.

1991 • 128 citations

Hyperhomocysteinemia as a Risk Factor for Arterial and Venous Disease. A Review of Evidence and Relevance

1997 • 110 citations

Polymorphism of the Methionine Synthase Gene

1999 • 99 citations

Higher Plasma Homocyst(e)ine and Increased Susceptibility to Adverse Effects of Low Folate in Early Familial Coronary Artery Disease

1995 • 89 citations

Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia

1996 • 85 citations

Deranged B12 metabolism: Effects on sulfur amino acid metabolism

1970 • 77 citations

Relationship Between Homocysteine and Thrombotic Disease

1998 • 69 citations

High-performance liquid chromatographic method with fluorescence detection for the determination of total homocyst(e)ine in plasma

1992 • 57 citations

Inborn Errors of Metabolism Causing Homocysteinemia and Related Vascular Involvement

1989 • 23 citations