Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

1995 • 1,158 citations

Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection

1995 • 1,008 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line

1987 • 936 citations

Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy

1993 • 803 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

1989 • 781 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency

1995 • 755 citations

The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4

1989 • 732 citations

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

1989 • 726 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

Quiescent T Lymphocytes as an Inducible Virus Reservoir in HIV-1 Infection

1991 • 584 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection

1995 • 411 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.

1995 • 386 citations

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

1995 • 385 citations

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene

1994 • 372 citations

Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity

1990 • 351 citations

Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1

1989 • 338 citations

Activation of virus replication after vaccination of HIV-1-infected individuals.

1995 • 332 citations

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

1994 • 305 citations

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

1989 • 293 citations

Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines

1992 • 289 citations

HIV accessory proteins: Leading roles for the supporting cast

1995 • 283 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

1995 • 252 citations

The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.

1994 • 250 citations

Human immunodeficiency virus type 1 Nef associateswith a cellular serine kinase in T lymphocytes.

1994 • 227 citations

Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV

1993 • 223 citations

Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1

1992 • 201 citations

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1991 • 192 citations

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef

1995 • 191 citations

Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells

1994 • 184 citations

Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family

1996 • 154 citations

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry

1995 • 140 citations

Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines

1995 • 128 citations

Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

1992 • 123 citations

A Conserved Domain and Membrane Targeting of Nef from HIV and SIV Are Required for Association with a Cellular Serine Kinase Activity

1995 • 122 citations

Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells

1993 • 118 citations

Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription.

1990 • 93 citations

Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 Nef gene-induced expression.

1996 • 76 citations

Viral latency in HIV disease

1995 • 74 citations

Suppression of interleukin-2 and interleukin-2 receptor expression in jurkat cells stably expressing the human immunodeficiency virus tat protein

1992 • 65 citations

Mechanisms of HIV-1 latency

1992 • 60 citations

Human immunodeficiency virus Tat induces functional unresponsiveness in T cells

1995 • 59 citations

HIV-1 Nef Protein Inhibits the Recruitment of AP-1 DNA-Binding Activity in Human T-Cells

1993 • 58 citations

The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent

1996 • 56 citations

HIV-1 Nef activity in murine T cells. CD4 modulation and positive enhancement.

1994 • 54 citations

The HIV-1 nef gene acts as a positive viral infectivity factor

1994 • 47 citations

Activation Pathways and Human Immunodeficiency Virus Type 1 Replication Are Not Altered in CD4⁺T Cells Expressing thenefProtein

1992 • 31 citations

HLA Class‐II‐restricted Mycobacterium lepraereactive T‐Cell Clones from Leprosy Patients Established with a Minimal Requirement for Autologous Mononuclear Cells

1986 • 26 citations

Context-dependent role of human immunodeficiency virus type 1 auxiliary genes in the establishment of chronic virus producers

1993 • 25 citations

T-cell receptor beta-chain gene usage in the T-cell recognition of Mycobacterium leprae antigens in one tuberculoid leprosy patient.

1992 • 23 citations

Role of HIV-1 Nef Expression in Activation Pathways in CD4⁺T Cells

1994 • 13 citations

Comparison of three different forms of HLA‐DR4Dw4 proteins

1993 • 7 citations