Dietary Selenium Reduces the Formation of Aberrant Crypts in Rats Administered 3,2′-Dimethyl-4-aminobiphenyl

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population

1993 • 1,783 citations

Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings

1987 • 1,036 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

1995 • 553 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

Aberrant crypts: putative preneoplastic foci in human colonic mucosa.

1991 • 448 citations

Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.

1994 • 393 citations

Acetylator genotype and arylamine-induced carcinogenesis

1988 • 325 citations

Aberrant crypts: potential preneoplastic lesions in the murine colon.

1988 • 305 citations

Possible protective effect of selenium against human cancer.

1969 • 304 citations

Chemical form of selenium, critical metabolites, and cancer prevention.

1991 • 302 citations

Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.

1994 • 286 citations

K-ras Mutations in Putative Preneoplastic Lesions in Human Colon

1993 • 224 citations

Formation and persistence of arylamine DNA adducts in vivo.

1985 • 214 citations

Activity of methylated forms of selenium in cancer prevention.

1990 • 214 citations

Prospective Study of Toenail Selenium Levels and Cancer Among Women

1995 • 213 citations

Selenium in Forage Crops and Cancer Mortality in U.S. Counties

1991 • 206 citations

Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods.

1989 • 164 citations

Dissociation of the genotoxic and growth inhibitory effects of selenium

1995 • 154 citations

The epidemiology of selenium and cancer.

1985 • 152 citations

Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon

1995 • 142 citations

Classification of aberrant crypt foci and microadenomas in human colon.

1991 • 142 citations

Second malignant neoplasms among long-term survivors of ovarian cancer.

1996 • 139 citations

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1995 • 130 citations

A Prospective Cohort Study on Toenail Selenium Levels and Risk of Gastrointestinal Cancer

1993 • 122 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.

1992 • 120 citations

Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene

1979 • 117 citations

Chemoprevention of cancer by organoselenium compounds

1995 • 108 citations

Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention

1994 • 104 citations

Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium

1995 • 94 citations

Selenium content of foods purchased in North Dakota

1996 • 91 citations

Effect of an inorganic and organic form of dietary selenium on the promotional stage of mammary carcinogenesis in the rat.

1984 • 85 citations

Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection

1989 • 82 citations

Biochemical and Molecular Aspects of Selected Cancers

1991 • 74 citations

Selenium-enriched garlic inhibits the early stage but not the late stage of mammary carcinogenesis

1996 • 73 citations

Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxymethane in Fischer-344 rats on high-risk diet

1994 • 67 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary tumors and DNA adducts by dietary selenite.

1991 • 64 citations

Carcinoembryonic antigen in human colonic aberrant crypt foci

1994 • 59 citations

Human aberrant crypt foci with carcinoma in situ from a patient with sporadic colon cancer

1996 • 58 citations

Chemoprevention of experimental mammary carcinogenesis by the synthetic organoselenium compound, benzylselenocyanate, in rats

1989 • 58 citations

Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.

1993 • 56 citations

Experimental Colon Carcinogenesis

2019 • 55 citations

Colonic aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic lesions in colon cancer

1992 • 53 citations

DNA adducts formed from the probable proximate carcinogen, N-hydroxy-3,2′ -dimethyl-4-aminobiphenyl, by acid catalysis or S-acetyl coenzyme A-dependent enzymatic esterification

1985 • 48 citations

Differential Effect of Dietary Methionine on the Biopotency of Selenomethionine and Selenite in Cancer Chemoprevention1

1988 • 45 citations

Evaluation of organoselenium compounds for potential chemopreventive properties in colon carcinogenesis.

1994 • 43 citations

Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2′-dimethyl-4-aminobiphenyl

1990 • 43 citations

Cancer chemoprevention by aliphatic selenocyanates: effect of chain length on inhibition of mammary tumors and DMBA adducts

1995 • 37 citations

Expression of ras oncogene mRNA and protein in aberrant crypt foci

1992 • 37 citations

Effect of dietary benzylselenocyanate on azoxymethane‐induced colon carcinogenesis in Male F344 rats

1991 • 34 citations

Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl.

1996 • 32 citations

The Chemical Form of Selenium Influences 3,2′-Dimethyl-4-aminobiphenyl-DNA Adduct Formation in Rat Colon

1999 • 31 citations

Aromatic and heterocyclic amine metabolism and phenotyping in humans.

1991 • 28 citations

The effect of disulfiram on the carcinogenicity of 3,2' dimethyl-4-aminobiphenyl in Syrian golden hamsters and rats

1981 • 25 citations

In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.

1983 • 23 citations

Higher Frequency of Aberrant Crypt Foci in Rapid Than Slow Acetylator Inbred Rats Administered the Colon Carcinogen 3,2′-Dimethyl-4-aminobiphenyl

1997 • 22 citations

Biochemical and Molecular Aspects of Selected Cancers

1994 • 21 citations

Alterations Associated with Early Neoplasia in the Colon

1994 • 17 citations

The epidemiology of selenium and cancer.

1987 • 14 citations

REDUCTION OF THE INCIDENCE OF METACHRONOUS ADENOMAS OF THE LARGE BOWEL BY MEANS OF ANTIOXIDANTS: A DOUBLE BLIND RANDOMIZED TRIAL

1999 • 8 citations

Experimental Colon Carcinogenesis

1978 • 5 citations

Cited By (0)

Loading...