Chemopreventive Agents

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

1973 • 7,616 citations

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population

1993 • 1,783 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

1985 • 961 citations

SELENOCYSTEINE

1996 • 788 citations

PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCER

1983 • 556 citations

Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.

1993 • 550 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Cancer mortality correlation studies-III: Statistical associations with dietary selenium intakes

1977 • 497 citations

Nutrition Intervention Trials in Linxian, China: Multiple Vitamin/Mineral Supplementation, Cancer Incidence, and Disease-Specific Mortality Among Adults With Esophageal Dysplasia

1993 • 425 citations

Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data.

1985 • 322 citations

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

1996 • 309 citations

Possible protective effect of selenium against human cancer.

1969 • 304 citations

Chemical form of selenium, critical metabolites, and cancer prevention.

1991 • 302 citations

Supplementation with selenium and human immune cell functions

1994 • 295 citations

ASSOCIATION BETWEEN SERUM SELENIUM AND THE RISK OF CANCER

1984 • 287 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

Selenium Distribution and Human Cancer Mortality

1971 • 266 citations

Hepatic iodothyronine 5′-deiodinase. The role of selenium

1990 • 259 citations

Relationship of Selenium to Cancer. I. Inhibitory Effect of Selenium on Carcinogenesis

1970 • 259 citations

Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer.

1989 • 228 citations

Activity of methylated forms of selenium in cancer prevention.

1990 • 214 citations

Prospective Study of Toenail Selenium Levels and Cancer Among Women

1995 • 213 citations

Cloning of a cDNA for the Type II Iodothyronine Deiodinase

1995 • 212 citations

Selenium in Forage Crops and Cancer Mortality in U.S. Counties

1991 • 206 citations

Cloning and Expression of a cDNA for a Mammalian Type III Iodothyronine Deiodinase

1995 • 200 citations

Role of Selenium in The Chemoprevention of Cancer

1979 • 193 citations

Prevention of Exudative Diathesis in Chicks by Factor 3 and Selenium

1957 • 187 citations

Active Oxygen Generation by the Reaction of Selenite with Reduced Glutathione in Vitro

1989 • 179 citations

Factors Influencing the Inhibitory Effect of Selenium on Mice Inoculated with Ehrlich Ascites Tumor Cells

1980 • 177 citations

Synergistic effect of vitamin E and selenium in the chemoprevention of mammary carcinogenesis in rats.

1983 • 171 citations

Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors

1977 • 168 citations

Effects of Various Dietary Levels of Selenium as Selenite or Selenomethionine on Tissue Selenium Levels and Glutathione Peroxidase Activity in Rats

1988 • 162 citations

Cancer mortality correlation studies-IV: Associations with dietary intakes and blood levels of certain trace elements, notably se-antagonists

1977 • 161 citations

Supplementation with selenium and human immune cell functions

1994 • 161 citations

Nutritional and Hormonal Regulation of Thyroid Hormone Deiodinases

1995 • 160 citations

SERUM LEVELS OF SELENIUM AND RETINOL AND THE SUBSEQUENT RISK OF CANCER

1988 • 157 citations

Comparison of selenium and sulfur analogs in cancer prevention

1992 • 157 citations

Selenium-dependent glutathione peroxidase protein and activity: immunological investigations on cellular and plasma enzymes

1986 • 152 citations

Determination of the Distribution of Selenium between Glutathione Peroxidase, Selenoprotein P, and Albumin in Plasma

1993 • 148 citations

The Protective Role of Glutathione Peroxidase in Apoptosis Induced by Reactive Oxygen Species

1996 • 147 citations

Molecular biology of selenium with implications for its metabolism ¹

1991 • 143 citations

Prediagnostic Serum Selenium in a Case-Control Study of Thyroid Cancer

1989 • 143 citations

Human [74Se]selenomethionine metabolism: a kinetic model

1991 • 140 citations

Serum Selenium and the Risk of Cancer, by Specific Sites: Case-Control Analysis of Prospective Data<xref ref-type="fn" rid="FN2">2</xref>

1987 • 140 citations

A prospective cohort study on selenium status and the risk of lung cancer.

1993 • 139 citations

SEROLOGIC PRECURSORS OF CANCER

1987 • 138 citations

Comparison of the effects of an organic and an inorganic form of selenium on a mammary carcinoma cell line

1994 • 136 citations

Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phases of chemical carcinogenesis.

1981 • 132 citations

The selenium metabolite selenodiglutathione induces p⁵³ and apoptosis: relevance to the chemopreventive effects of selenium?

1994 • 132 citations

Prospective Study of Serum Micronutrients and Ovarian Cancer

1996 • 128 citations

Selenotrisulfides. II. Cross-linking of reduced pancreatic ribonuclease with selenium

1969 • 125 citations

A Prospective Cohort Study on Toenail Selenium Levels and Risk of Gastrointestinal Cancer

1993 • 122 citations

Purification of selenoprotein P from human plasma

1994 • 121 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.

1992 • 120 citations

Rat skeletal muscle selenoprotein W: cDNA clone and mRNA modulation by dietary selenium.

1995 • 120 citations

IS SERUM SELENIUM A RISK FACTOR FOR CANCER IN MEN ONLY?1

1987 • 116 citations

Selenium and cancer.

1988 • 111 citations

Inhibitory effects of selenium on the growth of L1210 leukemic cells.

1981 • 110 citations

Current Ideas on Selenium as a Chemopreventive Agent

1988 • 110 citations

Serum vitamin E, serum selenium and the risk of gastrointestinal cancer

1988 • 107 citations

Enhancement of mammary tumorigenesis by dietary selenium deficiency in rats with a high polyunsaturated fat intake.

1981 • 106 citations

Influence of Dietary Selenium and Vitamin E on the Humoral Immune Response of the Chick

1981 • 105 citations

Effect of Dietary Selenium on N-2 Fluorenyl-Acetamide (FAA)-Induced Cancer in Vitamin E Supplemented, Selenium Depleted Rats

1972 • 104 citations

Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention

1994 • 104 citations

Selenium and the immune response

1991 • 104 citations

Inhibitory effects of selenium on the mutagenicity of 2-acetylaminofluorene (AAF) and AAF derivatives

1977 • 100 citations

Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin.

1987 • 98 citations

Regional variation of cancer mortality incidence and its relation to selenium levels in China

1985 • 93 citations

Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps.

1993 • 93 citations

Effects of Dietary Selenium on UVB-Induced Skin Carcinogenesis and Epidermal Antioxidant Status

1994 • 92 citations

Serum selenium and risk of cancer. A prospective follow-up of nine years

1987 • 87 citations

Supplementation with selenium augments the functions of natural killer and lymphokine-activated killer cells

1996 • 86 citations

Human selenite metabolism: a kinetic model

1989 • 85 citations

Effect of Selenium and Vitamin E Dietary Deficiencies on Chick Lymphoid Organ Development

1986 • 84 citations

Serum selenium concentration associated with risk of cancer.

1988 • 83 citations

Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection

1989 • 82 citations

Selenium Inhibition of <italic>N</italic>-Methyl-<italic>N</italic>-nitrosourea-Induced Mammary Carcinogenesis in the Rat<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>, <xref ref-type="fn" rid="fn4">4</xref>

1980 • 81 citations

Factors Influencing the Antitumorigenic Properties of Selenium in Mice

1983 • 80 citations

Effect of dietary vitamin E and selenium on the phytohaemagglutinin response of pig lymphocytes

1981 • 80 citations

Chronic toxicity and retention of dietary selenium fed to rats as D- or L-selenomethionine, selenite, or selenate

1987 • 80 citations

Selenium inhibition of chemical carcinogenesis.

1985 • 76 citations

Chemoprevention of mammary tumorigenesis by a combined regimen of selenium and vitamin A

1981 • 75 citations

Newly found selenium-containing proteins in the tissues of the rat

1996 • 75 citations

Grace A. Goldsmith Award lecture. Trace element regulation of immunity and infection.

1985 • 74 citations

Macrophage, lymphocyte and chronic inflammatory responses in selenium deficient rodents. Association with decreased glutathione peroxidase activity

1983 • 71 citations

Characterization of tissue selenium profiles and anticarcinogenic responses in rats fed natural sources of selenium-rich products

1994 • 70 citations

Effects of organoselenium compounds on induction of mouse forestomach tumors by benzo(a)pyrene.

1985 • 68 citations

Selenium and cellular immunity

1995 • 67 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary tumors and DNA adducts by dietary selenite.

1991 • 64 citations

Immune responses in rats supplemented with selenium.

1986 • 64 citations

Apoptosis induced by selenium in human glioma cell lines

1996 • 62 citations

Inhibitory effects of selenium on 1,2- dimethylhydrazine and methylazoxymethanol colon carcinogenesis.Correlative studies on selenium effects on the mutagenicity and sister chromatid exchange rates of selected carcinogens

1977 • 61 citations

Differential effects of selenium on normal and neoplastic canine mammary cells.

1986 • 61 citations

Mechanisms of Selenium Inhibition of Tumorigenesis

1986 • 60 citations

Selenium inhibition of 1,2-dimethylhydrazine-induced colon carcinogenesis.

1983 • 60 citations

Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis.

1981 • 60 citations

Selenium inhibition of DNA synthesis in mouse mammary epithelial cell line YN-4.

1984 • 59 citations

Chemoprevention of experimental mammary carcinogenesis by the synthetic organoselenium compound, benzylselenocyanate, in rats

1989 • 58 citations

Adaptive Changes in Hepatic Glutathione Metabolism in Response to Excess Selenium in Rats

1983 • 56 citations

Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats.

1991 • 56 citations

Mammary cancer chemoprevention by inorganic and organic selenium: single agent treatment or in combination with vitamin E and their effects on in vitro immune functions

1987 • 54 citations

Effect of selenium on virally induced and transplantable tumor models.

1985 • 53 citations

Combination of blocking agents and suppressing agents in cancer prevention

1991 • 52 citations

Effects of selenium on cell proliferation in rat liver and mammalian cells as indicated by cytokinetic and biochemical analysis.

1985 • 52 citations

Effects of selenium on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis and DNA adduct formation.

1985 • 51 citations

Selenium and the Immune Response: 2. Enhancement of Murine Cytotoxic T-Lymphocyte and Natural Killer Cell Cytotoxicity In Vivo

1989 • 50 citations

Effects of Dietary Selenium and Vitamin E on Hepatic Mixed-Function Oxidase Activities and In Vivo Covalent Binding of Aflatoxin B1 in Rats

1982 • 50 citations

Effects of Dietary Selenium and Vitamin E on Covalent Binding of Aflatoxin to Chick Liver Cell Macromolecules

1982 • 49 citations

High levels of reactive oxygen metabolites in colon cancer tissue: Analysis by chemiluminescence probe

1992 • 49 citations

Effect of Dietary Vitamin E and Selenium Deficiency On Chicken Splenocyte Proliferan and Cell Surface Marker Expresssion

1994 • 49 citations

A case‐control study of oral cancer and pre‐diagnostic concentrations of selenium and zinc in nail tissue

1991 • 48 citations

Induction of DNA repair by some selenium compounds

1980 • 47 citations

Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell culture model

1995 • 46 citations

Mechanisms of Selenium Inhibition of Tumorigenesis

1986 • 45 citations

The selenium metabolite selenodiglutathione induces cell death by a mechanism distinct from H₂O₂ toxicity

1995 • 45 citations

Antioxidant Effects on Cell-Mediated Immunity

1985 • 45 citations

Effect of selenium on growth rate of canine mammary carcinoma cells in athymic nude mice

1982 • 44 citations

Dietary selenium intake and growth of the MT-W9B transplantable rat mammary tumor

1981 • 43 citations

Effect of Selenium on the Expression of High Affinity Interleukin 2 Receptors

1992 • 43 citations

Chemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats.

1987 • 42 citations

Deficient levels of dietary selenium suppress the antibody response in first and second generation mice

1985 • 42 citations

Effect of short-term feeding of sodium selenite on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in the rat.

1982 • 41 citations

Is serum selenium a risk factor for cancer?

1985 • 41 citations

Enhancement of BOP‐induced pancreatic carcinogenesis in selenium‐fed Syrian Golden hamsters under specific dietary conditions

1988 • 41 citations

Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.

1985 • 39 citations

Cellular immune responses in pigs fed a vitamin E- and selenium-deficient diet.

1991 • 38 citations

Cancer chemoprevention by aliphatic selenocyanates: effect of chain length on inhibition of mammary tumors and DMBA adducts

1995 • 37 citations

Effect of selenium on the induction of breast fibroadenomas by adenovirus type 9 and 1,2‐dimethylhydrazine‐induced bowel carcinogenesis in rats

1982 • 36 citations

Inhibition of Na, K-ATPase by sodium selenite and reversal by glutathione

1986 • 34 citations

Inhibition of the growth of malignant mouse lymphoid cells by selenodiglutathione and selenodicysteine

1981 • 33 citations

Inhibition of Pancreatic and Liver Carcinogenesis in Rats by Retinoid- and Selenium-Supplemented Diets

1988 • 33 citations

Indirect inactivation of eukaryotic initiation factor 2 in reticulocyte lysate by selenite.

1980 • 32 citations

The Interconversion and Reutilization of Injected 75Se-Selenomethionine in the Rat

1967 • 32 citations

Modification of mammary carcinogenesis and tissue peroxidation by selenium deficiency and dietary fat

1981 • 31 citations

Effect of dietary excess of inorganic selenium during initiation and postinitiation phases of colon carcinogenesis in F344 rats.

1988 • 31 citations

Alteration of natural killer cell-mediated cytotoxicity in rats treated with selenium, diethylnitrosamine and ethylnitrosourea

1984 • 30 citations

Current Concepts of Selenium and Mammary Tumorigenesis

1987 • 30 citations

The effects of dietary selenium on the biotransformation of 7,12-dimethylbenz[a]anthracene

1982 • 30 citations

Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: role of dietary vitamin E.

1986 • 29 citations

Novel Strategies in Selenium Cancer Chemoprevention Research

1994 • 29 citations

Effects of sodium selenite on DNA and carcinogen-induced DNA repair in human diploid fibroblasts

1987 • 29 citations

Nutrition and the immune response.

1978 • 28 citations

Biological activities of trimethylselenonium as influenced by arsenite

1992 • 28 citations

Enhancement of ovine lymphocyte responses: A comparison of selenium and vitamin E supplementation

1989 • 26 citations

Selenium as an anticarcinogen

1984 • 26 citations

Selenite: a good inhibitor of rat-liver DNA methylase.

1985 • 26 citations

Inhibitory effects of selenium on mutagenicity

1984 • 25 citations

Mode of Action of Selenium Inhibition of 7,12-Dimethylbenz[<italic>a</italic>]anthracene-Induced Mouse Mammary Tumorigenesis<xref ref-type="fn" rid="FN1">2</xref>

1985 • 25 citations

Effect of selenium on malignant tumor cells of brain

1995 • 24 citations

The anti-leukaemic effects and the mechanism of sodium selenite

1992 • 24 citations

Effects of dietary selenium on hepatic and renal tumorigenesis induced in rats by diethylnitrosamine

1985 • 23 citations

Scavengers of Oxygen-Derived Free Radicals Prolong Survival in Advanced Colonic Cancer

1993 • 23 citations

Selenium and Cabbage and Colon Carcinogenesis in Mice

1987 • 22 citations

Effect of dietary selenium on the metabolism and excretion of 2‐acetylaminofluorene in the rat

1982 • 22 citations

Immunoregulation of natural and lymphokine-activated killer cells by selenium

1990 • 21 citations

The effects of dietary fat and selenium on the development of preneoplastic lesions in rat liver

1986 • 21 citations

Uptake and localization of selenium-75 in mammary epithelial cell lines in vitro

1982 • 20 citations

SELENIUM AND CANCER

1986 • 19 citations

Influence of dietary vitamin E and selenium on metabolic activation of chemicals to mutagens

1984 • 17 citations

Selenium modified mutagenicity and metabolism of benzo[a]pyrene in an S9-dependent system

1984 • 16 citations

Dietary selenium, hepatic arylhydrocarbon hydroxylase and mutagenic activation of benzo(a)pyrene, 2-aminoanthracene and 2-aminofluorene

1982 • 14 citations

Effect of dietary selenium and vitamin E deficiencies in the chicken on Con A induced splenocyte proliferation.

1987 • 11 citations

Selenium inhibition of avian fatty acid synthetase complex

1977 • 9 citations

Dietary selenium deficiency causes decreased N-oxygenation of N,N-dimethylaniline and increased mutagenicity of diemthylnitrosamine in the isolated rat liver/cell culture system

1984 • 9 citations

The effect of selenium on cell proliferation in liver and colon

1986 • 8 citations

Evidence for a defective mitochondrial membrane in 1,2-dimethylhydrazine-induced colon adenocarcinoma in rat: Enhanced lipid peroxidation potential in vitro

1980 • 6 citations

Selenium

2021 • 3 citations