Study on the mechanisms of diarrhea induced by a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats.

Intestinal Epithelial Cell Surface Membrane Glycoprotein Synthesis

1973 • 1,111 citations

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 • 855 citations

Neuropharmacology of emesis induced by anti-cancer therapy

1988 • 332 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Atropine, scopolamine and related antimuscarinic drugs

1990 • 278 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Response of the rat small-intestine epithelium to methotrexate.

1980 • 128 citations

Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5‐hydroxytryptamine receptor (type 3) antagonist

1990 • 108 citations

Mechanisms of action of loperamide.

1984 • 96 citations

Changes in the mucosa of the small intestine following methotrexate administration or abdominal X‐irradiation

1974 • 95 citations

Clonidine delays small intestinal transit in the rat.

1980 • 93 citations

Two types of receptors for 5‐hydroxytryptamine on the cholinergic nerves of the guinea‐pig myenteric plexus

1985 • 66 citations

Cholinergic modulation of the release of 5-hydroxytryptamine from the guinea pig ileum

1987 • 60 citations

INHIBITION BY MORPHINE OF PROSTAGLANDIN E₁‐STIMULATED SECRETION AND CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE FORMATION IN THE RAT JEJUNUM in vivo

1980 • 60 citations

THE ACTION OF MORPHINE, PETHIDINE, AND AMIDONE UPON THE INTESTINAL MOTILITY OF CONSCIOUS DOGS

1950 • 44 citations

Lactobacilli as effectors of host functions: no influence on the activities of enzymes in enterocytes of mice

1987 • 24 citations

Cecectomized rat

1990 • 22 citations

New drug treatments for diarrhoea

1990 • 14 citations

Effects of mitomycin C, 5-fluorouracil and cyclophosphamide on drug absorption, enzyme activities and mucosal lipid composition of intestine.

1987 • 13 citations

Comparison of intestinal toxic effects of platinum complexes: cisplatin (CDDP), carboplatin (CBDCA), and iproplatin (CHIP)

1988 • 13 citations